Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury

• Published in: Cell reports (Cambridge) Vol. 43; no. 1; p. 113591
• Main Authors: Yang, Chun-Ju, Chang, Hao-Chun, Sung, Pin-Cheng, Ge, Mao-Cheng, Tang, Hsiang-Yu, Cheng, Mei-Ling, Cheng, Hao-Tsai, Chou, Hong-Hsue, Lin, Cheng-Yu, Lin, Wey-Ran, Lee, Yun-Shien, Hsieh, Sen-Yung
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.01.2024; Elsevier
• Subjects: acetaminophen; acute liver failure; Animals; Butyrates; CP: Cell biology; CP: Microbiology; DILI; drug-induced liver injury; Fecal Microbiota Transplantation; Feces; ferroptosis; FMT; gut-liver axis; Humans; Liver; Mice; Nrf2; short-chain fatty acids; drug-induced liver injury; acetaminophen; DILI; ferroptosis; CP: Cell biology; acute liver failure; gut-liver axis; Nrf2; CP: Microbiology; FMT; short-chain fatty acids; fecal microbiota transplantation

While fecal microbiota transplantation (FMT) shows promise in treating human diseases, oral capsule FMT is more accepted and accessible to patients. However, microbe selection in the upper gastrointestinal tract (UGIT) through oral administration remains unclear. Here, we demonstrate that short-term...