Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis

• Published in: Cell reports (Cambridge) Vol. 26; no. 13; pp. 3657 - 3671.e5
• Main Authors: Zhu, Qing, Ding, Ling, Zi, Zhenguo, Gao, Shujun, Wang, Chong, Wang, Yuyan, Zhu, Caixia, Yuan, Zhenghong, Wei, Fang, Cai, Qiliang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.03.2019; Elsevier
• Subjects: Adult; Aged; Animals; AURKB; Aurora Kinase B - metabolism; Carcinogenesis; cell segregation; Chromosome Segregation; EBV; Female; HEK293 Cells; HeLa Cells; Herpesvirus 8, Human - physiology; HPV; Humans; KSHV; Male; Mice; Mice, Inbred NOD; Middle Aged; Mitosis; Neoplasms - metabolism; Neoplasms - virology; Oncogenic Viruses - physiology; oncovirus; protein cleavage; tumorigenesis; Xenograft Model Antitumor Assays; Young Adult; oncovirus; KSHV; protein cleavage; EBV; cell segregation; tumorigenesis; AURKB; HPV

Aurora kinase B (AURKB), a central regulator of chromosome segregation and cytokinesis, is aberrantly expressed in various cancer cells. However, the relationship of AURKB and oncogenic viruses in cancer progression remains unclear. Here, we reveal that N-cleaved isoforms of AURKB exist in several o...