A calorimetric and spectroscopic comparison of the effects of cholesterol and its sulfur-containing analogs thiocholesterol and cholesterol sulfate on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

• Published in: Biochimica et biophysica acta Vol. 1858; no. 2; pp. 168 - 180
• Main Authors: Benesch, Matthew G.K., Lewis, Ruthven N.A.H., McElhaney, Ronald N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2016
• Subjects: 1,2-Dipalmitoylphosphatidylcholine; Calorimetry, Differential Scanning; Cholesterol; Cholesterol - analogs & derivatives; Cholesterol - chemistry; Cholesterol Esters - chemistry; Cholesterol sulfate; Dipalmitoylphosphatidylcholine; Humans; Lipid bilayer membranes; Lipid Bilayers - chemistry; Spectroscopy, Fourier Transform Infrared; Sterol/phospholipid interactions; Thiocholesterol; Sterol/phospholipid interactions; Chol; ΔT1/2; CholS; tChol; DSC; FTIR; Tm; Cholesterol sulfate; DMPC; Tp; DPPC; Dipalmitoylphosphatidylcholine; Thiocholesterol; Lipid bilayer membranes; SDPC; Pβ; Lo; ESR; Lα; SOPC; Lβ′ and Lβ; Cholesterol; NMR; PC; ΔH

We performed differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectroscopic studies of the effects of cholesterol (Chol), thiocholesterol (tChol) and cholesterol sulfate (CholS) on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine (DPPC)...