Revisiting the therapeutic potential of gingerols against different pharmacological activities

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 396; no. 4; pp. 633 - 647
• Main Authors: Sharma, Samridhi, Shukla, Monu Kumar, Sharma, Krishan Chander, Tirath, Kumar, Lokender, Anal, Jasha Momo H., Upadhyay, Santosh Kumar, Bhattacharyya, Sanjib, Kumar, Deepak
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023; Springer Nature B.V
• Subjects: Alzheimer's disease; Antioxidants; Apoptosis; Archives & records; Arthritis; Biomedical and Life Sciences; Biomedicine; Cancer; Catechols - pharmacology; Catechols - therapeutic use; Cell cycle; Cell division; Chronic pain; Diabetes mellitus; Essential oils; Fatty Alcohols - chemistry; Fatty Alcohols - pharmacology; Fatty Alcohols - therapeutic use; Menstruation; Metabolic disorders; Nausea; Neurodegenerative diseases; Neurosciences; Osteoarthritis; Pharmaceutical sciences; Pharmacology; Pharmacology/Toxicology; Phenolic compounds; Plant Extracts - chemistry; Resins; Review; Rheumatoid arthritis; Rhizomes; Zingiber officinale - chemistry; Zingiber officinale - metabolism; Inflammation; Ginger; Gingerol; Volatile oil; Resins; Cancer; Zingiber officinale
• ISSN: 0028-1298; 1432-1912
• DOI: 10.1007/s00210-022-02372-7

The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases. Graphical Abstract