A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract

• Published in: Cellular & molecular immunology Vol. 17; no. 11; pp. 1119 - 1125
• Main Authors: Hu, Fengyu, Chen, Fengjuan, Ou, Zhihua, Fan, Qinghong, Tan, Xinghua, Wang, Yaping, Pan, Yuejun, Ke, Bixia, Li, Linghua, Guan, Yujuan, Mo, Xiaoneng, Wang, Jian, Wang, Jinlin, Luo, Chun, Wen, Xueliang, Li, Min, Ren, Peidi, Ke, Changwen, Li, Junhua, Lei, Chunliang, Tang, Xiaoping, Li, Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2020; Nature Publishing Group
• Subjects: 631/250/255/2514; 692/53/2423; Antibodies; Antibodies, Viral - metabolism; Betacoronavirus - physiology; Biomedical and Life Sciences; Biomedicine; Clinical Laboratory Techniques - methods; Coronaviridae; Coronavirus Infections - diagnosis; Coronavirus Infections - immunology; Coronaviruses; COVID-19; COVID-19 Testing; Epitopes - immunology; Gastrointestinal tract; Gastrointestinal Tract - virology; Humans; Immune clearance; Immune response; Immune response (humoral); Immunity, Humoral; Immunoglobulin A; Immunoglobulin A - metabolism; Immunoglobulin G; Immunoglobulin G - metabolism; Immunology; Medical Microbiology; Microbiology; mRNA; Pandemics; Pneumonia, Viral - diagnosis; Pneumonia, Viral - immunology; Protein Binding; Protein Domains - immunology; Public health; SARS-CoV-2; Secondary infection; Serologic Tests; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; Vaccine; Viral Load; Virus Shedding; SARS-CoV-2; gastrointestinal infection; protective antibody; virus recurrence

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyz...