Intrinsically Disordered Protein TEX264 Mediates ER-phagy

• Published in: Molecular cell Vol. 74; no. 5; pp. 909 - 921.e6
• Main Authors: Chino, Haruka, Hatta, Tomohisa, Natsume, Tohru, Mizushima, Noboru
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2019
• Subjects: Amino Acid Sequence - genetics; Autophagy - genetics; Autophagy-Related Proteins - chemistry; Autophagy-Related Proteins - genetics; Cell Cycle Proteins - genetics; Endoplasmic Reticulum - chemistry; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum Stress - genetics; ER-phagy; Humans; Intracellular Signaling Peptides and Proteins; Intrinsically Disordered Proteins - chemistry; Intrinsically Disordered Proteins - genetics; intrinsically disordered region; Membrane Proteins; Microtubule-Associated Proteins - genetics; Neoplasm Proteins - genetics; organellar contact site; Proteolysis; selective autophagy; organellar contact site; intrinsically disordered region; ER-phagy; selective autophagy

Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that bind to autophagosomal LC3 and GABARAP family proteins. Here, we performed a differential interactome screen using wild-type LC3B...