The relationship of renal function to outcome: A post hoc analysis from the EdoxabaN versus warfarin in subjectS UndeRgoing cardiovErsion of Atrial Fibrillation (ENSURE-AF) study

• Published in: The American heart journal Vol. 193; pp. 16 - 22
• Main Authors: Lip, Gregory Y.H., Al-Saady, Naab, Ezekowitz, Michael D., Banach, Maciej, Goette, Andreas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017; Elsevier Limited
• Subjects: Aged; Anticoagulants; Anticoagulants - administration & dosage; Atrial Fibrillation - complications; Atrial Fibrillation - therapy; Bleeding; Cardiac arrhythmia; Cardiovascular disease; Clinical outcomes; Continuity (mathematics); Creatinine; Creatinine - metabolism; Dose-Response Relationship, Drug; Drug dosages; Effectiveness; Electric Countershock - methods; Factor Xa Inhibitors - administration & dosage; Female; Fibrillation; Glomerular Filtration Rate - drug effects; Glycoproteins; Heart; Humans; Kidney - drug effects; Kidney - physiopathology; Kidney diseases; Male; Middle Aged; P-Glycoprotein; Patients; Pyridines - administration & dosage; Renal function; Safety; Strata; Stroke; Thiazoles - administration & dosage; Thromboembolism; Thromboembolism - etiology; Thromboembolism - prevention & control; Treatment Outcome; Warfarin; Warfarin - administration & dosage; Weight reduction

The ENSURE-AF study (NCT 02072434) of anticoagulation for electrical cardioversion in nonvalvular atrial fibrillation (NVAF) showed comparable low rates of bleeding and thromboembolism between the edoxaban and the enoxaparin-warfarin treatment arms. This post hoc analysis investigated the relationsh...