Evaluating the application value of NGS-based PGT-A by screening cryopreserved MDA products of embryos from PGT-M cycles with known transfer outcomes

• Published in: Journal of assisted reproduction and genetics Vol. 39; no. 6; pp. 1323 - 1331
• Main Authors: Shen, Xiaoting, Chen, Dongjia, Ding, Chenhui, Xu, Yan, Fu, Yu, Cai, Bing, Wang, Yali, Wang, Jing, Li, Rong, Guo, Jing, Pan, Jiafu, Zhang, Han, Zeng, Yanhong, Zhou, Canquan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2022; Springer Nature B.V
• Subjects: Abortion, Spontaneous - genetics; Abortion, Spontaneous - pathology; Aneuploidy; Assisted Reproduction Technologies; Biopsy; Blastocyst - pathology; Case-Control Studies; Cryopreservation; Embryo transfer; Embryos; Female; Genetic screening; Genetic Testing; Gynecology; High-Throughput Nucleotide Sequencing; Human Genetics; Humans; Medicine; Medicine & Public Health; Miscarriage; Mosaicism; Next-generation sequencing; Pregnancy; Preimplantation Diagnosis; Reproductive Medicine; Retrospective Studies; Trophectoderm; Frozen-thawed embryo transfer; Next-generation sequencing; Multiple displacement amplification; Miscarriage; Preimplantation genetic testing for aneuploidies

Purpose To determine the application value of next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidies (PGT-A). Methods We conducted a retrospective case–control study on a cohort of frozen-thawed embryo transfer (FET) cycles following preimplantation genetic testing f...