Organophosphate flame retardants (OPFRs) induce genotoxicity in vivo: A survey on apoptosis, DNA methylation, DNA oxidative damage, liver metabolites, and transcriptomics

• Published in: Environment international Vol. 130; p. 104914
• Main Authors: Chen, Rui, Hou, Rui, Hong, Xiangsheng, Yan, Saihong, Zha, Jinmiao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2019; Elsevier
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Cyprinidae - metabolism; DNA Damage; DNA Methylation - drug effects; DNA oxidative damage; DNA repair; Female; Flame Retardants - toxicity; Liver - drug effects; Liver - metabolism; Male; Mutagenicity Tests; Mutagens - toxicity; Organophosphates - toxicity; Organophosphorus Compounds - toxicity; RNA-seq; Transcriptome - drug effects; Water Pollutants, Chemical - toxicity; DNA oxidative damage; RNA-seq; DNA repair; Apoptosis

As potential substitutes for polybrominated diphenyl ethers (PBDEs), organophosphate flame retardants (OPFRs) have been frequently detected in the environment. However, the genotoxicity induced by these OPFRs has rarely been described, and the results reported in previous studies are conflicting and...