Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium
The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept in standa...
Saved in:
| Published in | Ecotoxicology and environmental safety Vol. 250; p. 114486 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
15.01.2023
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0147-6513 1090-2414 1090-2414 |
| DOI | 10.1016/j.ecoenv.2022.114486 |
Cover
| Abstract | The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept in standard medium (without cadmium). The phenotype analysis showed that cadmium induced developmental defects on wings and apoptosis in the wing disc cells of Drosophila (F0). The wing defects were transmitted for at least four generations even without Cd afterwards. And the effect on the mRNA expression of wing development related genes (shg, omb, F-actin, Mekk1) can be maintained for at least two or three generations. More importantly, under cadmium stress, the post-translational modification (PTM) on the histones H3K4me3 in the third instar larvae and ovaries or testes of adult flies increased significantly, while the levels of H3K9me3 and H3K27me3 decreased significantly. The expression of histone methylation related genes (dSet-1, ash1, Lsd1) increased significantly and these changes can be transmitted to offspring from one or two generations in ovaries or testes. These results suggest that the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium.
•Cd exposure caused wing development defects in Drosophila, and could be transmitted in F1-F4 generations when Cd removed.•Expressions of wing development related genes were changed under Cd exposure and could be transmitted to 2 or 3 generations.•Cd exposure changed expressions of H3K4me3, H3K9me3, H3K27me3 and histone methylation related genes in Drosophila.•Expression changes of histone methylation related genes and H3K4me3 could be transmitted to 1 or 2 generations. |
|---|---|
| AbstractList | The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F
) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F
-F
) were continuously kept in standard medium (without cadmium). The phenotype analysis showed that cadmium induced developmental defects on wings and apoptosis in the wing disc cells of Drosophila (F
). The wing defects were transmitted for at least four generations even without Cd afterwards. And the effect on the mRNA expression of wing development related genes (shg, omb, F-actin, Mekk1) can be maintained for at least two or three generations. More importantly, under cadmium stress, the post-translational modification (PTM) on the histones H3K4me3 in the third instar larvae and ovaries or testes of adult flies increased significantly, while the levels of H3K9me3 and H3K27me3 decreased significantly. The expression of histone methylation related genes (dSet-1, ash1, Lsd1) increased significantly and these changes can be transmitted to offspring from one or two generations in ovaries or testes. These results suggest that the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium. The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept in standard medium (without cadmium). The phenotype analysis showed that cadmium induced developmental defects on wings and apoptosis in the wing disc cells of Drosophila (F0). The wing defects were transmitted for at least four generations even without Cd afterwards. And the effect on the mRNA expression of wing development related genes (shg, omb, F-actin, Mekk1) can be maintained for at least two or three generations. More importantly, under cadmium stress, the post-translational modification (PTM) on the histones H3K4me3 in the third instar larvae and ovaries or testes of adult flies increased significantly, while the levels of H3K9me3 and H3K27me3 decreased significantly. The expression of histone methylation related genes (dSet-1, ash1, Lsd1) increased significantly and these changes can be transmitted to offspring from one or two generations in ovaries or testes. These results suggest that the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium. The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept in standard medium (without cadmium). The phenotype analysis showed that cadmium induced developmental defects on wings and apoptosis in the wing disc cells of Drosophila (F0). The wing defects were transmitted for at least four generations even without Cd afterwards. And the effect on the mRNA expression of wing development related genes (shg, omb, F-actin, Mekk1) can be maintained for at least two or three generations. More importantly, under cadmium stress, the post-translational modification (PTM) on the histones H3K4me3 in the third instar larvae and ovaries or testes of adult flies increased significantly, while the levels of H3K9me3 and H3K27me3 decreased significantly. The expression of histone methylation related genes (dSet-1, ash1, Lsd1) increased significantly and these changes can be transmitted to offspring from one or two generations in ovaries or testes. These results suggest that the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium. •Cd exposure caused wing development defects in Drosophila, and could be transmitted in F1-F4 generations when Cd removed.•Expressions of wing development related genes were changed under Cd exposure and could be transmitted to 2 or 3 generations.•Cd exposure changed expressions of H3K4me3, H3K9me3, H3K27me3 and histone methylation related genes in Drosophila.•Expression changes of histone methylation related genes and H3K4me3 could be transmitted to 1 or 2 generations. The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept in standard medium (without cadmium). The phenotype analysis showed that cadmium induced developmental defects on wings and apoptosis in the wing disc cells of Drosophila (F0). The wing defects were transmitted for at least four generations even without Cd afterwards. And the effect on the mRNA expression of wing development related genes (shg, omb, F-actin, Mekk1) can be maintained for at least two or three generations. More importantly, under cadmium stress, the post-translational modification (PTM) on the histones H3K4me3 in the third instar larvae and ovaries or testes of adult flies increased significantly, while the levels of H3K9me3 and H3K27me3 decreased significantly. The expression of histone methylation related genes (dSet-1, ash1, Lsd1) increased significantly and these changes can be transmitted to offspring from one or two generations in ovaries or testes. These results suggest that the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium.The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured in the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept in standard medium (without cadmium). The phenotype analysis showed that cadmium induced developmental defects on wings and apoptosis in the wing disc cells of Drosophila (F0). The wing defects were transmitted for at least four generations even without Cd afterwards. And the effect on the mRNA expression of wing development related genes (shg, omb, F-actin, Mekk1) can be maintained for at least two or three generations. More importantly, under cadmium stress, the post-translational modification (PTM) on the histones H3K4me3 in the third instar larvae and ovaries or testes of adult flies increased significantly, while the levels of H3K9me3 and H3K27me3 decreased significantly. The expression of histone methylation related genes (dSet-1, ash1, Lsd1) increased significantly and these changes can be transmitted to offspring from one or two generations in ovaries or testes. These results suggest that the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium. |
| ArticleNumber | 114486 |
| Author | Han, Xiaobing Mu, Yun Gu, Wei Xu, Lu Sun, Liran Zhang, Min |
| Author_xml | – sequence: 1 givenname: Liran surname: Sun fullname: Sun, Liran email: liransun@snnu.edu.cn – sequence: 2 givenname: Yun surname: Mu fullname: Mu, Yun email: muyun@snnu.edu.cn – sequence: 3 givenname: Lu surname: Xu fullname: Xu, Lu email: luxu@snnu.edu.cn – sequence: 4 givenname: Xiaobing surname: Han fullname: Han, Xiaobing email: xiaobinghan@snnu.edu.cn – sequence: 5 givenname: Wei surname: Gu fullname: Gu, Wei email: weigu@snnu.edu.cn – sequence: 6 givenname: Min surname: Zhang fullname: Zhang, Min email: zhangmin451@snnu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36587412$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUtv1DAUhS1URKcD_wChLNlk6utHHiyQUHm0UiU2ZW059k3qUWIPdjJV_z0e0rJgASu_zjm2v3NBznzwSMhboDugUF3ud2gC-uOOUcZ2AEI01QuyAdrSkgkQZ2RDQdRlJYGfk4uU9pRSTqV8Rc55JZtaANuQ4S5qnwb0GPXsgtdj4fw9Rjdrb7AIffHg_FBYPOIYDhP6Oc97NHPKuuJzDCkc7t2oiwlH7cOg04wxH9nFoC26x8JoO7llek1e9npM-OZp3JIfX7_cXV2Xt9-_3Vx9ui2NqMVc6lo2XPaWGlF1jdEdSslt34maQ0N7XUkGwCy0dWsBmgZFzSiY1jDGje4bviU3a64Neq8O0U06Pqqgnfq9EeKgdJydGVGhATQ5VkrkgmUigvc9ahAdBbR5tSXv16xDDD8XTLOaXDI45o9iWJJidUWhhjY_bkvePUmXbkL75-Jn0FnwYRWYjCxF7JXJiE_E56jdqICqU6tqr9ZW1alVtbaazeIv83P-f2wfVxtm4EeHUSXjMNdqXcwNZiLu3wG_ABM7vjA |
| CitedBy_id | crossref_primary_10_1371_journal_pone_0292179 crossref_primary_10_1098_rsob_240298 crossref_primary_10_1002_tox_24375 crossref_primary_10_1016_j_chemosphere_2024_142821 crossref_primary_10_1038_s44319_024_00245_z crossref_primary_10_5004_dwt_2023_29856 crossref_primary_10_1016_j_envint_2024_108952 crossref_primary_10_3390_ijms252010996 crossref_primary_10_1186_s12864_024_10824_y crossref_primary_10_1016_j_ecoenv_2025_117870 crossref_primary_10_1002_jat_4749 crossref_primary_10_1016_j_exger_2023_112256 crossref_primary_10_3389_fendo_2024_1399757 |
| Cites_doi | 10.1016/j.toxlet.2012.05.013 10.1186/s13148-018-0596-7 10.1016/bs.ctdb.2016.08.003 10.1093/bioinformatics/btaa920 10.1126/science.aah6412 10.1242/dev.141598 10.18632/aging.101107 10.1016/j.phrs.2021.105520 10.2174/1871524920666200924114524 10.1016/j.taap.2019.114684 10.1126/science.aab2006 10.1177/0748233720912060 10.1007/s10646-017-1831-2 10.1016/j.etap.2019.02.006 10.1242/dev.094300 10.1242/dev.01432 10.1111/brv.12322 10.1242/dev.117.3.1017 10.1016/0147-6513(94)90016-7 10.1038/s41556-020-0494-z 10.1016/j.cell.2009.02.015 10.1038/nature04433 10.1073/pnas.1420850112 10.1093/toxsci/kfv019 10.1093/carcin/bgl004 10.1371/journal.pone.0044139 10.1002/ece3.5692 10.1093/toxsci/kfh158 10.1038/nature10572 10.1038/srep38003 10.1016/j.marenvres.2020.105022 10.1016/j.ydbio.2007.08.003 10.1016/j.reprotox.2009.11.009 10.1016/j.gde.2007.12.003 10.1126/science.aam5339 10.3390/toxics8040094 10.1016/j.tig.2004.07.013 10.1016/j.ibmb.2020.103516 10.1002/jat.3597 10.1038/s41598-022-08758-0 10.1093/genetics/126.1.91 10.1534/genetics.118.301353 10.1016/j.tox.2021.152931 10.2217/epi.10.44 |
| ContentType | Journal Article |
| Copyright | 2022 The Authors Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2022 The Authors – notice: Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 DOA |
| DOI | 10.1016/j.ecoenv.2022.114486 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals (ODIN) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health Ecology |
| EISSN | 1090-2414 |
| ExternalDocumentID | oai_doaj_org_article_ec1ec31855e34265843ffea14b01ed84 36587412 10_1016_j_ecoenv_2022_114486 S0147651322013264 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAFWJ AAHBH AAIKJ AAKOC AALRI AAOAW AATTM AAXKI AAXUO ABFYP ABJNI ABLST ABMAC ACDAQ ACGFS ACRLP ADBBV ADEZE ADVLN AEBSH AEIPS AEKER AENEX AFJKZ AFPKN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AKIFW AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU AXJTR BKOJK BLECG BLXMC BNPGV CS3 DM4 DU5 EBS EFBJH EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA GROUPED_DOAJ IHE J1W KCYFY KOM LG5 LY8 M41 MO0 N9A O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SDP SES SPCBC SSH SSJ SSZ T5K ZU3 ~G- 29G 53G AAQFI AAQXK AAYWO AAYXX ABEFU ABFNM ABWVN ABXDB ACRPL ACVFH ADCNI ADFGL ADMUD ADNMO AEGFY AEUPX AFPUW AGCQF AGQPQ AGRNS AI. AIGII AIIUN AKBMS AKYEP APXCP ASPBG AVWKF AZFZN CAG CITATION COF EJD FEDTE FGOYB G-2 HMC HVGLF HZ~ H~9 R2- RIG SEN SEW VH1 WUQ XPP ZMT ZXP ~KM AFKWA AJOXV AMFUW CGR CUY CVF ECM EIF NPM 7X8 EFKBS |
| ID | FETCH-LOGICAL-c474t-a75835fd0c46b8cabe553dfb473180fa652112d1979d1188e47201c9c223caf83 |
| IEDL.DBID | AIKHN |
| ISSN | 0147-6513 1090-2414 |
| IngestDate | Wed Aug 27 01:32:08 EDT 2025 Fri Sep 05 11:00:39 EDT 2025 Wed Feb 19 02:25:59 EST 2025 Thu Apr 24 23:07:37 EDT 2025 Tue Jul 01 04:00:41 EDT 2025 Sun Apr 06 06:56:11 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Cadmium Wing defect Transgenerational inheritance Histone methylation Drosophila melanogaster |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-a75835fd0c46b8cabe553dfb473180fa652112d1979d1188e47201c9c223caf83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0147651322013264 |
| PMID | 36587412 |
| PQID | 2760171947 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_ec1ec31855e34265843ffea14b01ed84 proquest_miscellaneous_2760171947 pubmed_primary_36587412 crossref_citationtrail_10_1016_j_ecoenv_2022_114486 crossref_primary_10_1016_j_ecoenv_2022_114486 elsevier_sciencedirect_doi_10_1016_j_ecoenv_2022_114486 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-01-15 |
| PublicationDateYYYYMMDD | 2023-01-15 |
| PublicationDate_xml | – month: 01 year: 2023 text: 2023-01-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Ecotoxicology and environmental safety |
| PublicationTitleAlternate | Ecotoxicol Environ Saf |
| PublicationYear | 2023 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Gadhia, Calabro, Barile (bib7) 2012; 212 Schmidt, Ibrahim (bib33) 1994; 29 Agger, Christensen, Cloos, Helin (bib1) 2008; 18 Pflugfelder, Schwarz, Roth, Poeck, Sigl, Kerscher, Jonschker, Pak, Heisenberg (bib28) 1990; 126 Xia, Gerstin, Schones, Huang, Steven-de-Belle (bib39) 2016; 8 Pflugfelder, Eichinger, Shen (bib29) 2017; 122 Greer, Maures, Ucar, Hauswirth, Mancini, Lim, Benayoun, Shi, Brunet (bib9) 2011; 479 Cheng, Zhang, Wu, Jiang, Jia, Qing, An, Zhang, Su (bib4) 2019; 379 Ke, Davidson, Chen, Kluz, Costa (bib15) 2006; 27 Saedi, Shirazi, Zamiri, Totonchi, Dadpasand, Sedaghati (bib31) 2020; 36 Sankar, Lerdrup, Manaf, Johansen, Gonzalez, Borup, Blanshard, Klungland, Hansen, Andersen, Dahl, Helin, Hoffmann (bib32) 2020; 22 Castillo, Ibáñez, Guajardo, Llanos, Ronco (bib2) 2012; 7 Liang, Wu, Yao, Yu, Yang, Tan, Hylkema, Rots, Xu, Lau (bib18) 2018; 38 Zhang, Luo, Pflugfelder, Shen (bib44) 2013; 140 Massányi, Massányi, Madeddu, Stawarz, Lukáč (bib21) 2020; 8 Tsukada, Fang, Erdjument-Bromage, Warren, Borchers, Tempst, Zhang (bib37) 2006; 439 Somji, Garrett, Sens, Gurel, Sens (bib35) 2004; 80 Mu, Hu, Yang, Sun, Gu, Zhang (bib23) 2021; 462 Geng, Wang (bib8) 2019; 67 Hu, Gui, Chen, Chen (bib12) 2019; 9 Pérez-Garijo, Martín, Morata (bib27) 2004; 131 Crozatier, Glise, Vincent (bib5) 2004; 20 Szentgyörgyi, Moroń, Nawrocka, Tofilski, Woyciechowski (bib36) 2017; 26 Wang, Liu, Sun (bib38) 2017; 92 Mazurais, Servili, Noel, Cormier, Collet, Leseur, Le-Roy, Vitré, Madec, Zambonino-Infante (bib22) 2020; 159 Jarmasz, Stirton, Davie, Del, Bigio (bib13) 2019; 11 Siklenka, Erkek, Godmann, Lambrot, McGraw, Lafleur, Cohen, Xia, Suderman, Hallett, Trasler, Peters, Kimmins (bib34) 2015; 350 Xiao, Liu, Xie, Tu, Xia, Costa, Zhou (bib40) 2015; 145 Zenk, Loeser, Schiavo, Kilpert, Bogdanović, Iovino (bib43) 2017; 357 Poeck, Hofbauer, Pflugfelder (bib30) 1993; 117 Pastrana-Trejo, Duarte-Aké, Us-Camas, De-la-Peña, Parker, Pertwee, Murillo-Rodríguez (bib26) 2021; 21 Lu, Huang, Zhang, Xu, Nie (bib20) 2021; 170 Fan, Zhang, Wang, Shen (bib6) 2021; 129 Kreher, Takasaki, Cockrum, Sidoli, Garcia, Jensen, Strome (bib17) 2018; 210 Liu, Sun, Wang, Pflugfelder, Shen (bib19) 2016; 6 Ognjanović, Marković, Ethordević, Trbojević, Stajn, Saicić (bib24) 2010; 29 Yang, Yang, Sun, Han, Xu, Gu, Zhang (bib42) 2022; 12 Hao, Xin, Shi, Xin, Zhang, Guo, Wang, Hao (bib10) 2021; 37 Klosin, Casas, Hidalgo-Carcedo, Vavouri, Lehner (bib16) 2017; 356 Yang, Graves, Moya, Tao, Hamaratoglu, Gladden, Halder (bib41) 2015; 112 O'Keefe, Prober, Moyle, Rickoll, Edgar (bib25) 2007; 311 Hashimoto, Vertino, Cheng (bib11) 2010; 2 Katz, Edwards, Reinke, Kelly (bib14) 2009; 137 Chen, Huang, Huang, Austin, Hong (bib3) 2017; 144 Geng (10.1016/j.ecoenv.2022.114486_bib8) 2019; 67 Greer (10.1016/j.ecoenv.2022.114486_bib9) 2011; 479 Mu (10.1016/j.ecoenv.2022.114486_bib23) 2021; 462 Pflugfelder (10.1016/j.ecoenv.2022.114486_bib29) 2017; 122 Pflugfelder (10.1016/j.ecoenv.2022.114486_bib28) 1990; 126 Sankar (10.1016/j.ecoenv.2022.114486_bib32) 2020; 22 Tsukada (10.1016/j.ecoenv.2022.114486_bib37) 2006; 439 Zhang (10.1016/j.ecoenv.2022.114486_bib44) 2013; 140 Massányi (10.1016/j.ecoenv.2022.114486_bib21) 2020; 8 Xiao (10.1016/j.ecoenv.2022.114486_bib40) 2015; 145 Kreher (10.1016/j.ecoenv.2022.114486_bib17) 2018; 210 Saedi (10.1016/j.ecoenv.2022.114486_bib31) 2020; 36 Jarmasz (10.1016/j.ecoenv.2022.114486_bib13) 2019; 11 Liu (10.1016/j.ecoenv.2022.114486_bib19) 2016; 6 Xia (10.1016/j.ecoenv.2022.114486_bib39) 2016; 8 Hashimoto (10.1016/j.ecoenv.2022.114486_bib11) 2010; 2 Klosin (10.1016/j.ecoenv.2022.114486_bib16) 2017; 356 Hu (10.1016/j.ecoenv.2022.114486_bib12) 2019; 9 Ke (10.1016/j.ecoenv.2022.114486_bib15) 2006; 27 Katz (10.1016/j.ecoenv.2022.114486_bib14) 2009; 137 Yang (10.1016/j.ecoenv.2022.114486_bib41) 2015; 112 Poeck (10.1016/j.ecoenv.2022.114486_bib30) 1993; 117 Fan (10.1016/j.ecoenv.2022.114486_bib6) 2021; 129 Gadhia (10.1016/j.ecoenv.2022.114486_bib7) 2012; 212 Lu (10.1016/j.ecoenv.2022.114486_bib20) 2021; 170 Somji (10.1016/j.ecoenv.2022.114486_bib35) 2004; 80 O'Keefe (10.1016/j.ecoenv.2022.114486_bib25) 2007; 311 Yang (10.1016/j.ecoenv.2022.114486_bib42) 2022; 12 Crozatier (10.1016/j.ecoenv.2022.114486_bib5) 2004; 20 Liang (10.1016/j.ecoenv.2022.114486_bib18) 2018; 38 Pastrana-Trejo (10.1016/j.ecoenv.2022.114486_bib26) 2021; 21 Mazurais (10.1016/j.ecoenv.2022.114486_bib22) 2020; 159 Pérez-Garijo (10.1016/j.ecoenv.2022.114486_bib27) 2004; 131 Castillo (10.1016/j.ecoenv.2022.114486_bib2) 2012; 7 Hao (10.1016/j.ecoenv.2022.114486_bib10) 2021; 37 Cheng (10.1016/j.ecoenv.2022.114486_bib4) 2019; 379 Siklenka (10.1016/j.ecoenv.2022.114486_bib34) 2015; 350 Agger (10.1016/j.ecoenv.2022.114486_bib1) 2008; 18 Ognjanović (10.1016/j.ecoenv.2022.114486_bib24) 2010; 29 Chen (10.1016/j.ecoenv.2022.114486_bib3) 2017; 144 Wang (10.1016/j.ecoenv.2022.114486_bib38) 2017; 92 Schmidt (10.1016/j.ecoenv.2022.114486_bib33) 1994; 29 Zenk (10.1016/j.ecoenv.2022.114486_bib43) 2017; 357 Szentgyörgyi (10.1016/j.ecoenv.2022.114486_bib36) 2017; 26 |
| References_xml | – volume: 11 start-page: 5 year: 2019 ident: bib13 article-title: DNA methylation and histone post-translational modification stability in post-mortem brain tissue publication-title: Clin. Epigenetics – volume: 2 start-page: 657 year: 2010 end-page: 669 ident: bib11 article-title: Molecular coupling of DNA methylation and histone methylation publication-title: Epigenomics – volume: 26 start-page: 1031 year: 2017 end-page: 1040 ident: bib36 article-title: Forewing structure of the solitary bee publication-title: Ecotoxicology – volume: 357 start-page: 212 year: 2017 end-page: 216 ident: bib43 article-title: Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition publication-title: Science – volume: 140 start-page: 2917 year: 2013 end-page: 2922 ident: bib44 article-title: Dpp signaling inhibits proliferation in the publication-title: Development – volume: 38 start-page: 888 year: 2018 end-page: 895 ident: bib18 article-title: Epiproteome profiling of cadmium-transformed human bronchial epithelial cells by quantitative histone post-translational modification-enzyme-linked immunosorbent assay publication-title: J. Appl. Toxicol. – volume: 126 start-page: 91 year: 1990 end-page: 104 ident: bib28 article-title: Genetic and molecular characterization of the publication-title: Genetics – volume: 129 year: 2021 ident: bib6 article-title: T-box transcription factors publication-title: Insect Biochem. Mol. Biol. – volume: 22 start-page: 380 year: 2020 end-page: 388 ident: bib32 article-title: KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes publication-title: Nat. Cell Biol. – volume: 379 year: 2019 ident: bib4 article-title: Reproductive toxicity of acute Cd exposure in mouse: Resulting in oocyte defects and decreased female fertility publication-title: Toxicol. Appl. Pharmacol. – volume: 8 start-page: 2988 year: 2016 end-page: 3008 ident: bib39 article-title: Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in publication-title: Aging – volume: 145 start-page: 80 year: 2015 end-page: 89 ident: bib40 article-title: Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity publication-title: Toxicol. Sci. – volume: 8 start-page: 94 year: 2020 ident: bib21 article-title: Effects of cadmium, lead, and mercury on the structure and function of reproductive organs publication-title: Toxics – volume: 67 start-page: 102 year: 2019 end-page: 107 ident: bib8 article-title: Cadmium: toxic effects on placental and embryonic development publication-title: Environ. Toxicol. Pharmacol. – volume: 122 start-page: 313 year: 2017 end-page: 354 ident: bib29 article-title: T-Box genes in publication-title: Curr. Top. Dev. Biol. – volume: 170 year: 2021 ident: bib20 article-title: Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications publication-title: Pharmacol. Res. – volume: 12 start-page: 4762 year: 2022 ident: bib42 article-title: Effects of cadmium on oxidative stress and cell apoptosis in publication-title: Sci. Rep. – volume: 356 start-page: 320 year: 2017 end-page: 323 ident: bib16 article-title: Transgenerational transmission of environmental information in publication-title: Science – volume: 36 start-page: 63 year: 2020 end-page: 75 ident: bib31 article-title: Impaired follicular development and endocrine disorders in female rats by prepubertal exposure to toxic doses of cadmium publication-title: Toxicol. Ind. Health – volume: 112 start-page: 1785 year: 2015 end-page: 1790 ident: bib41 article-title: Differential regulation of the Hippo pathway by adherens junctions and apical-basal cell polarity modules publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 212 start-page: 169 year: 2012 end-page: 179 ident: bib7 article-title: Trace metals alter DNA repair and histone modification pathways concurrently in mouse embryonic stem cells publication-title: Toxicol. Lett. – volume: 92 start-page: 2084 year: 2017 end-page: 2111 ident: bib38 article-title: Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans publication-title: Biol. Rev. Camb. Philos. Soc. – volume: 137 start-page: 308 year: 2009 end-page: 320 ident: bib14 article-title: A publication-title: Cell – volume: 6 start-page: 38003 year: 2016 ident: bib19 article-title: Fold formation at the compartment boundary of publication-title: Sci. Rep. – volume: 21 start-page: 142 year: 2021 end-page: 147 ident: bib26 article-title: Effects on the post-translational modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 levels in cerebral cortex, hypothalamus and pons of rats after a systemic administration of Cannabidiol: a preliminary study publication-title: Cent. Nerv. Syst. Agents Med. Chem. – volume: 9 start-page: 11848 year: 2019 end-page: 11862 ident: bib12 article-title: Transcriptome profiling of maternal stress-induced wing dimorphism in pea aphids publication-title: Ecol. Evol. – volume: 20 start-page: 498 year: 2004 end-page: 505 ident: bib5 article-title: Patterns in evolution: veins of the publication-title: Trends Genet – volume: 117 start-page: 1017 year: 1993 end-page: 1029 ident: bib30 article-title: Expression of the publication-title: Development – volume: 29 start-page: 148 year: 1994 end-page: 164 ident: bib33 article-title: Heavy metal content (Hg publication-title: Ecotoxicol. Environ. Saf. – volume: 80 start-page: 358 year: 2004 end-page: 366 ident: bib35 article-title: Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd publication-title: Toxicol. Sci. – volume: 29 start-page: 191 year: 2010 end-page: 197 ident: bib24 article-title: Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q(10) and vitamin E publication-title: Reprod. Toxicol. – volume: 18 start-page: 159 year: 2008 end-page: 168 ident: bib1 article-title: The emerging functions of histone demethylases publication-title: Curr. Opin. Genet. Dev. – volume: 479 start-page: 365 year: 2011 end-page: 371 ident: bib9 article-title: Transgenerational epigenetic inheritance of longevity in publication-title: Nature – volume: 311 start-page: 25 year: 2007 end-page: 39 ident: bib25 article-title: Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the publication-title: Dev. Biol. – volume: 27 start-page: 1481 year: 2006 end-page: 1488 ident: bib15 article-title: Alterations of histone modifications and transgene silencing by nickel chloride publication-title: Carcinogenesis – volume: 210 start-page: 969 year: 2018 end-page: 982 ident: bib17 article-title: Distinct roles of two histone methyltransferases in transmitting H3K36me3-based epigenetic memory across generations in publication-title: Genetics – volume: 159 year: 2020 ident: bib22 article-title: Transgenerational regulation of cbln11 gene expression in the olfactory rosette of the European sea bass ( publication-title: Mar. Environ. Res. – volume: 131 start-page: 5591 year: 2004 end-page: 5598 ident: bib27 article-title: Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in publication-title: Development – volume: 37 start-page: 1039 year: 2021 end-page: 1044 ident: bib10 article-title: Paternal reprogramming-escape histone H3K4me3 marks located within promoters of RNA splicing genes publication-title: Bioinformatics – volume: 462 year: 2021 ident: bib23 article-title: The effects of cadmium on the development of publication-title: Toxicology – volume: 439 start-page: 811 year: 2006 end-page: 816 ident: bib37 article-title: Histone demethylation by a family of JmjC domain-containing proteins publication-title: Nature – volume: 350 start-page: aab2006 year: 2015 ident: bib34 article-title: Disruption of histone methylation in developing sperm impairs offspring health transgenerationally publication-title: Science – volume: 7 year: 2012 ident: bib2 article-title: Impact of cadmium exposure during pregnancy on hepatic glucocorticoid receptor methylation and expression in rat fetus publication-title: PLoS One – volume: 144 start-page: 1242 year: 2017 end-page: 1248 ident: bib3 article-title: Phosphorylation potential of publication-title: Development – volume: 212 start-page: 169 issue: 2 year: 2012 ident: 10.1016/j.ecoenv.2022.114486_bib7 article-title: Trace metals alter DNA repair and histone modification pathways concurrently in mouse embryonic stem cells publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2012.05.013 – volume: 11 start-page: 5 issue: 1 year: 2019 ident: 10.1016/j.ecoenv.2022.114486_bib13 article-title: DNA methylation and histone post-translational modification stability in post-mortem brain tissue publication-title: Clin. Epigenetics doi: 10.1186/s13148-018-0596-7 – volume: 122 start-page: 313 year: 2017 ident: 10.1016/j.ecoenv.2022.114486_bib29 article-title: T-Box genes in Drosophila limb development publication-title: Curr. Top. Dev. Biol. doi: 10.1016/bs.ctdb.2016.08.003 – volume: 37 start-page: 1039 issue: 8 year: 2021 ident: 10.1016/j.ecoenv.2022.114486_bib10 article-title: Paternal reprogramming-escape histone H3K4me3 marks located within promoters of RNA splicing genes publication-title: Bioinformatics doi: 10.1093/bioinformatics/btaa920 – volume: 356 start-page: 320 issue: 6335 year: 2017 ident: 10.1016/j.ecoenv.2022.114486_bib16 article-title: Transgenerational transmission of environmental information in C. elegans publication-title: Science doi: 10.1126/science.aah6412 – volume: 144 start-page: 1242 issue: 7 year: 2017 ident: 10.1016/j.ecoenv.2022.114486_bib3 article-title: Phosphorylation potential of Drosophila E-Cadherin intracellular domain is essential for development and adherens junction biosynthetic dynamics regulation publication-title: Development doi: 10.1242/dev.141598 – volume: 8 start-page: 2988 issue: 11 year: 2016 ident: 10.1016/j.ecoenv.2022.114486_bib39 article-title: Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila publication-title: Aging doi: 10.18632/aging.101107 – volume: 170 year: 2021 ident: 10.1016/j.ecoenv.2022.114486_bib20 article-title: Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2021.105520 – volume: 21 start-page: 142 issue: 2 year: 2021 ident: 10.1016/j.ecoenv.2022.114486_bib26 article-title: Effects on the post-translational modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 levels in cerebral cortex, hypothalamus and pons of rats after a systemic administration of Cannabidiol: a preliminary study publication-title: Cent. Nerv. Syst. Agents Med. Chem. doi: 10.2174/1871524920666200924114524 – volume: 379 year: 2019 ident: 10.1016/j.ecoenv.2022.114486_bib4 article-title: Reproductive toxicity of acute Cd exposure in mouse: Resulting in oocyte defects and decreased female fertility publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2019.114684 – volume: 350 start-page: aab2006 issue: 6261 year: 2015 ident: 10.1016/j.ecoenv.2022.114486_bib34 article-title: Disruption of histone methylation in developing sperm impairs offspring health transgenerationally publication-title: Science doi: 10.1126/science.aab2006 – volume: 36 start-page: 63 issue: 2 year: 2020 ident: 10.1016/j.ecoenv.2022.114486_bib31 article-title: Impaired follicular development and endocrine disorders in female rats by prepubertal exposure to toxic doses of cadmium publication-title: Toxicol. Ind. Health doi: 10.1177/0748233720912060 – volume: 26 start-page: 1031 issue: 8 year: 2017 ident: 10.1016/j.ecoenv.2022.114486_bib36 article-title: Forewing structure of the solitary bee Osmia bicornis developing on heavy metal pollution gradient publication-title: Ecotoxicology doi: 10.1007/s10646-017-1831-2 – volume: 67 start-page: 102 year: 2019 ident: 10.1016/j.ecoenv.2022.114486_bib8 article-title: Cadmium: toxic effects on placental and embryonic development publication-title: Environ. Toxicol. Pharmacol. doi: 10.1016/j.etap.2019.02.006 – volume: 140 start-page: 2917 issue: 14 year: 2013 ident: 10.1016/j.ecoenv.2022.114486_bib44 article-title: Dpp signaling inhibits proliferation in the Drosophila wing by Omb-dependent regional control of bantam publication-title: Development doi: 10.1242/dev.094300 – volume: 131 start-page: 5591 issue: 22 year: 2004 ident: 10.1016/j.ecoenv.2022.114486_bib27 article-title: Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila publication-title: Development doi: 10.1242/dev.01432 – volume: 92 start-page: 2084 issue: 4 year: 2017 ident: 10.1016/j.ecoenv.2022.114486_bib38 article-title: Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans publication-title: Biol. Rev. Camb. Philos. Soc. doi: 10.1111/brv.12322 – volume: 117 start-page: 1017 issue: 3 year: 1993 ident: 10.1016/j.ecoenv.2022.114486_bib30 article-title: Expression of the Drosophila optomotor-blind gene transcript in neuronal and glial cells of the developing nervous system publication-title: Development doi: 10.1242/dev.117.3.1017 – volume: 29 start-page: 148 issue: 2 year: 1994 ident: 10.1016/j.ecoenv.2022.114486_bib33 article-title: Heavy metal content (Hg2+, Cd2+, Pb2+) in various body parts: its impact on cholinesterase activity and binding glycoproteins in the grasshopper Aiolopus thalassinus adults publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/0147-6513(94)90016-7 – volume: 22 start-page: 380 issue: 4 year: 2020 ident: 10.1016/j.ecoenv.2022.114486_bib32 article-title: KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes publication-title: Nat. Cell Biol. doi: 10.1038/s41556-020-0494-z – volume: 137 start-page: 308 issue: 2 year: 2009 ident: 10.1016/j.ecoenv.2022.114486_bib14 article-title: A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory publication-title: Cell doi: 10.1016/j.cell.2009.02.015 – volume: 439 start-page: 811 issue: 7078 year: 2006 ident: 10.1016/j.ecoenv.2022.114486_bib37 article-title: Histone demethylation by a family of JmjC domain-containing proteins publication-title: Nature doi: 10.1038/nature04433 – volume: 112 start-page: 1785 issue: 6 year: 2015 ident: 10.1016/j.ecoenv.2022.114486_bib41 article-title: Differential regulation of the Hippo pathway by adherens junctions and apical-basal cell polarity modules publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1420850112 – volume: 145 start-page: 80 issue: 1 year: 2015 ident: 10.1016/j.ecoenv.2022.114486_bib40 article-title: Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfv019 – volume: 27 start-page: 1481 issue: 7 year: 2006 ident: 10.1016/j.ecoenv.2022.114486_bib15 article-title: Alterations of histone modifications and transgene silencing by nickel chloride publication-title: Carcinogenesis doi: 10.1093/carcin/bgl004 – volume: 7 issue: 9 year: 2012 ident: 10.1016/j.ecoenv.2022.114486_bib2 article-title: Impact of cadmium exposure during pregnancy on hepatic glucocorticoid receptor methylation and expression in rat fetus publication-title: PLoS One doi: 10.1371/journal.pone.0044139 – volume: 9 start-page: 11848 issue: 20 year: 2019 ident: 10.1016/j.ecoenv.2022.114486_bib12 article-title: Transcriptome profiling of maternal stress-induced wing dimorphism in pea aphids publication-title: Ecol. Evol. doi: 10.1002/ece3.5692 – volume: 80 start-page: 358 issue: 2 year: 2004 ident: 10.1016/j.ecoenv.2022.114486_bib35 article-title: Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd+2-exposed human proximal tubule cells publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfh158 – volume: 479 start-page: 365 issue: 7373 year: 2011 ident: 10.1016/j.ecoenv.2022.114486_bib9 article-title: Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans publication-title: Nature doi: 10.1038/nature10572 – volume: 6 start-page: 38003 year: 2016 ident: 10.1016/j.ecoenv.2022.114486_bib19 article-title: Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis publication-title: Sci. Rep. doi: 10.1038/srep38003 – volume: 159 year: 2020 ident: 10.1016/j.ecoenv.2022.114486_bib22 article-title: Transgenerational regulation of cbln11 gene expression in the olfactory rosette of the European sea bass (Dicentrarchus labrax) exposed to ocean acidification publication-title: Mar. Environ. Res. doi: 10.1016/j.marenvres.2020.105022 – volume: 311 start-page: 25 issue: 1 year: 2007 ident: 10.1016/j.ecoenv.2022.114486_bib25 article-title: Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2007.08.003 – volume: 29 start-page: 191 issue: 2 year: 2010 ident: 10.1016/j.ecoenv.2022.114486_bib24 article-title: Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q(10) and vitamin E publication-title: Reprod. Toxicol. doi: 10.1016/j.reprotox.2009.11.009 – volume: 18 start-page: 159 issue: 2 year: 2008 ident: 10.1016/j.ecoenv.2022.114486_bib1 article-title: The emerging functions of histone demethylases publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2007.12.003 – volume: 357 start-page: 212 issue: 6347 year: 2017 ident: 10.1016/j.ecoenv.2022.114486_bib43 article-title: Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition publication-title: Science doi: 10.1126/science.aam5339 – volume: 8 start-page: 94 issue: 4 year: 2020 ident: 10.1016/j.ecoenv.2022.114486_bib21 article-title: Effects of cadmium, lead, and mercury on the structure and function of reproductive organs publication-title: Toxics doi: 10.3390/toxics8040094 – volume: 20 start-page: 498 issue: 10 year: 2004 ident: 10.1016/j.ecoenv.2022.114486_bib5 article-title: Patterns in evolution: veins of the Drosophila wing publication-title: Trends Genet doi: 10.1016/j.tig.2004.07.013 – volume: 129 year: 2021 ident: 10.1016/j.ecoenv.2022.114486_bib6 article-title: T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner publication-title: Insect Biochem. Mol. Biol. doi: 10.1016/j.ibmb.2020.103516 – volume: 38 start-page: 888 issue: 6 year: 2018 ident: 10.1016/j.ecoenv.2022.114486_bib18 article-title: Epiproteome profiling of cadmium-transformed human bronchial epithelial cells by quantitative histone post-translational modification-enzyme-linked immunosorbent assay publication-title: J. Appl. Toxicol. doi: 10.1002/jat.3597 – volume: 12 start-page: 4762 issue: 1 year: 2022 ident: 10.1016/j.ecoenv.2022.114486_bib42 article-title: Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae publication-title: Sci. Rep. doi: 10.1038/s41598-022-08758-0 – volume: 126 start-page: 91 issue: 1 year: 1990 ident: 10.1016/j.ecoenv.2022.114486_bib28 article-title: Genetic and molecular characterization of the optomotor-blind gene locus in Drosophila melanogaster publication-title: Genetics doi: 10.1093/genetics/126.1.91 – volume: 210 start-page: 969 issue: 3 year: 2018 ident: 10.1016/j.ecoenv.2022.114486_bib17 article-title: Distinct roles of two histone methyltransferases in transmitting H3K36me3-based epigenetic memory across generations in Caenorhabditis elegans publication-title: Genetics doi: 10.1534/genetics.118.301353 – volume: 462 year: 2021 ident: 10.1016/j.ecoenv.2022.114486_bib23 article-title: The effects of cadmium on the development of Drosophila and its transgenerational inheritance effects publication-title: Toxicology doi: 10.1016/j.tox.2021.152931 – volume: 2 start-page: 657 issue: 5 year: 2010 ident: 10.1016/j.ecoenv.2022.114486_bib11 article-title: Molecular coupling of DNA methylation and histone methylation publication-title: Epigenomics doi: 10.2217/epi.10.44 |
| SSID | ssj0003055 |
| Score | 2.4453554 |
| Snippet | The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 114486 |
| SubjectTerms | Animals Cadmium Cadmium - toxicity DNA Methylation Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Epigenesis, Genetic Histone methylation Histones - genetics Histones - metabolism Phenotype Transgenerational inheritance Wing defect Wings, Animal - abnormalities |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlEAiUkkcfmyZBgV5NJEuy7GObByGQnBLITch6LFt2vSXdTci_74xkb5ND2EtuxpbtQTPyfCPPfEPID85aWUdkfgwOAhSvWWGZ8kVAuq2mAoyRujdc31SXd_LqXt2_aPWFOWGZHjhP3Ak8Ijgs8VVBgDcBfyliDJbLlvHg68QEyho2BFP9Nxh5rHLyoi4qxcVQNJcyuyCuC90jxIZliVS5EuuoXzilxN3_yje9hT2TD7rYJp968Eh_ZqF3yIfQ7ZLN80Q8_bxLPuY9OJpLi_bIODmicSKWzlt-dNJhvd8CVU3nkT6B46L-f94QHKf0DhhHzx5Si4PJ1NJZmNpuPrZIqgCXPJiDp-0zddbPJsvZZ3J3cX57eln0jRUKJ7VcFBaCBKGiZ05Wbe1sG5QSPrZSw0SzaCvw6bz0vNGNhwCkDlIDTnCNAyzhbKzFF7LRzbvwjVDLWiVFqJmoo4RLtSxl5eGbKbR0DZcjIoaZNa5nHcfmF1MzpJf9NlkfBvVhsj5GpFjd9SezbqwZ_wuVthqLnNnpBFiS6S3JrLOkEdGDyk0PPzKsgEdN1rz-eLAQA6sTf7nYLsyXf02JKUeaN1KPyNdsOishBYgAeK7cfw_hv5MtEAhT4wquDsjG4mEZDgEuLdqjtDL-AVzmD-g priority: 102 providerName: Directory of Open Access Journals |
| Title | Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium |
| URI | https://dx.doi.org/10.1016/j.ecoenv.2022.114486 https://www.ncbi.nlm.nih.gov/pubmed/36587412 https://www.proquest.com/docview/2760171947 https://doaj.org/article/ec1ec31855e34265843ffea14b01ed84 |
| Volume | 250 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED9tnZCQEILxVT4qI_EaGsd2nDyOsamA2BOT9hY5tlNlatOptJv2wt_OnZ0U9oAm8ZbEdmz5zvdh3_0M8IGntSwaQn70Fh0Up9PEpMolnuC2yhxtjHB7w_ezfHYuv16oiz04HnJhKKyyl_1Rpgdp3X-Z9rM5vWrbKYUl6VyRN0XnBbnchwPsIFcjODj68m12thPIBGoVIxl1Qg2GDLoQ5oVOnu-u0VHMMsLNlZRU_ZeGCkD-dxTVvwzRoJBOn8Dj3pJkR3GwT2HPd4fw4CSgUN8ewqO4IcdintEzmAetNA8o03H_j7UdJf9tiO5s1bAb1GLM_QkiwucQ64H12Od1uO-gXRi29AvTreaGEBawyCFvOFbfMmvcst0un8P56cmP41nS37KQWKnlJjHoMQjVuNTKvC6sqb1SwjW11Ljc08bkqOB55nipS4feSOGlxgm3pUXDwpqmEC9g1K06_wqYSWslhS9SUTQSiwqZydyhABVa2pLLMYhhZivbQ5DTTRiLaog1u6wiPSqiRxXpMYZk1-oqQnDcU_8TEW1XlwC0w4fVel71HITNuLeUOa68QCMFzTDRNN5wWafcuwKHqgeSV3f4EX_V3tP9-4FDKlyqdP5iOr_a_qwyij_SvJR6DC8j6-wGKXAIaNxlr_-73zfwEN8oOC7h6i2MNuutf4cG06aewP7HX3zSL4tJ2Hb4DTUoFCY |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBbphtJCKW36yPapQq9mbUuy7GOaJmyaZE8J5CZkPRaHXTtsd1Py7zsj2dvmUAK9GUuyhWY0D_ubT4R8zdKalx6ZH52BBMXKNNGpsIlDuq2qgBgjnN5wPiuml_zHlbjaIYdDLQzCKnvbH216sNb9nUm_mpObppkgLEkWArMp_F9Q8EdklwvI9kZk9-DkdDrbGmQktYpIRpnggKGCLsC8IMlz7S0kinmOvLkci6r_8lCByP-eo_pXIBoc0vEL8ryPJOlBnOxLsuPaPfL4KLBQ3-2RZ_GDHI11Rq_IPHileWCZjt__aNNi8d8a5U47T3-BF6P2D4gIrgPWA_rR76tw3kGz0HTpFrrt5hoZFqDJgm5YWt9Ro-2y2Sxfk8vjo4vDadKfspAYLvk60ZAxMOFtanhRl0bXTghmfc0lbPfU6wIcfJbbrJKVhWykdFzCgpvKQGBhtC_ZGzJqu9btE6rTWnDmypSVnkNTyXNeWDCgTHJTZXxM2LCyyvQU5HgSxkINWLNrFeWhUB4qymNMku2om0jB8UD_byi0bV8k0A43utVc9RoEwzJnsHJcOAZBCoRhzHunM16nmbMlTFUOIlf39BEe1Tzw-i-DhijYqvj_Rbeu2_xUOeKPZFZxOSZvo-psJ8lgChDc5e_--72fyZPpxfmZOjuZnb4nT6EFgXJJJj6Q0Xq1cR8heFrXn_rN8RtVHhUg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transgenerational+inheritance+of+wing+development+defects+in+Drosophila+melanogaster+induced+by+cadmium&rft.jtitle=Ecotoxicology+and+environmental+safety&rft.au=Sun%2C+Liran&rft.au=Mu%2C+Yun&rft.au=Xu%2C+Lu&rft.au=Han%2C+Xiaobing&rft.date=2023-01-15&rft.pub=Elsevier+Inc&rft.issn=0147-6513&rft.volume=250&rft_id=info:doi/10.1016%2Fj.ecoenv.2022.114486&rft.externalDocID=S0147651322013264 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0147-6513&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0147-6513&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0147-6513&client=summon |