RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth

• Published in: Cell death and differentiation Vol. 28; no. 11; pp. 3052 - 3076
• Main Authors: Dasgupta, Shayani, Ghosh, Tithi, Dhar, Jesmita, Bhuniya, Avishek, Nandi, Partha, Das, Arnab, Saha, Akata, Das, Juhina, Guha, Ipsita, Banerjee, Saptak, Chakravarti, Mohona, Dasgupta, Partha Sarathi, Alam, Neyaz, Chakrabarti, Jayanta, Majumdar, Subrata, Chakrabarti, Pinak, Storkus, Walter J., Baral, Rathindranath, Bose, Anamika
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2021; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/1; 13/109; 13/2; 13/21; 13/31; 13/51; 13/89; 13/95; 14; 631/67/2328; 631/67/327; 96/100; AKT protein; Animals; Apoptosis; Bax protein; Biochemistry; Biomedical and Life Sciences; Caspase; Cell Biology; Cell Cycle Analysis; Female; G protein-coupled receptors; Growth regulators; Humans; Life Sciences; Medical prognosis; Mice; Mitochondria; Neoplasms - genetics; p53 Protein; Pericytes; Pericytes - metabolism; RGS Proteins - metabolism; Signal Transduction; Smad2 protein; Smad2 Protein - metabolism; Smad4 protein; Stem Cells; Transfection; Tumor microenvironment; Tumors

Regulator-of-G-protein-signaling-5 (RGS5), a pro-apoptotic/anti-proliferative protein, is a signature molecule of tumor-associated pericytes, highly expressed in several cancers, and is associated with tumor growth and poor prognosis. Surprisingly, despite the negative influence of intrinsic RGS5 ex...