Co-exposure of polystyrene microplastics and iron aggravates cognitive decline in aging mice via ferroptosis induction

• Published in: Ecotoxicology and environmental safety Vol. 233; p. 113342
• Main Authors: Liu, Xiu, Yang, Hekai, Yan, Xinzhu, Xu, Shuangfeng, Fan, Yonggang, Xu, He, Ma, Yue, Hou, Weijian, Javed, Rabia, Zhang, Yanhui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.03.2022; Elsevier
• Subjects: Aging; Aging brain; Animals; Cognitive Dysfunction - chemically induced; Cognitive impairment; Ferroptosis; Iron; Iron - toxicity; Mammals; Mice; Microplastics; MPs; Neurotoxicity; Plastics; Polystyrenes - toxicity; Water Pollutants, Chemical - toxicity; MPs; Neurotoxicity; Iron; Mammals; Aging brain; Cognitive impairment
• ISSN: 0147-6513; 1090-2414; 1090-2414
• DOI: 10.1016/j.ecoenv.2022.113342

The objective of this study was to investigate the effects of co-exposure of iron and microplastics (MPs) on the cognitive function of aged humans and animals. It was already known that individual iron or MPs exposure can initiate potential neurotoxicity. However, the combined effect of MPs and iron...