Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells

• Published in: Cell death & disease Vol. 11; no. 7; p. 583
• Main Authors: Chen, Qian, Jiang, Sijia, Liu, Haihua, Gao, Yue, Yang, Xiaoxue, Ren, Zhonglu, Gao, Yunfei, Xiao, Lu, Hu, Haoyue, Yu, Yanhong, Yang, Xinping, Zhong, Mei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.07.2020; Springer Nature B.V
• Subjects: 631/136/1425; 631/337/384; Adult; Age; Antibodies; Biochemistry; Biomedical and Life Sciences; CCCTC-Binding Factor - metabolism; CCR7 protein; Cell Biology; Cell Culture; Cell Cycle Checkpoints - genetics; Cell Death - genetics; Cell Line; Cell migration; Cell Movement - genetics; Cell Proliferation - genetics; Female; Gene expression; Humans; Immunology; Life Sciences; Non-coding RNA; Pathogenesis; Placenta; Placenta - pathology; Pre-eclampsia; Pre-Eclampsia - genetics; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Promoter Regions, Genetic - genetics; Protein Binding; Receptors, CCR7 - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Subcellular Fractions - metabolism; Transcription; Transcription, Genetic; Trophoblasts - metabolism; Trophoblasts - pathology; Up-Regulation - genetics; Uterus

Accumulating evidence suggests that the pathogenesis of preeclampsia involves poor placentation caused by insufficient trophoblast invasion and impaired uterine spiral artery remodeling, yet the underlying molecular mechanism remains unclear. We carried out transcriptome profiling on placentae from...