SARS-CoV-2, myocardial injury and inflammation: insights from a large clinical and autopsy study

• Published in: Clinical research in cardiology Vol. 110; no. 11; pp. 1822 - 1831
• Main Authors: Dal Ferro, Matteo, Bussani, Rossana, Paldino, Alessia, Nuzzi, Vincenzo, Collesi, Chiara, Zentilin, Lorena, Schneider, Edoardo, Correa, Ricardo, Silvestri, Furio, Zacchigna, Serena, Giacca, Mauro, Metra, Marco, Merlo, Marco, Sinagra, Gianfranco
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2021; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Antigens; Autopsies; Autopsy; Cardiology; Cardiomyocytes; Cohort Studies; Coronaviruses; COVID-19; COVID-19 - complications; Damage; Female; Genomes; Heart diseases; Humans; Hybridization; Immunohistochemistry; Inflammation; Inflammation - epidemiology; Inflammation - virology; Injuries; Male; Medicine; Medicine & Public Health; Myocarditis; Myocarditis - epidemiology; Myocarditis - virology; Myocardium - pathology; Myocytes, Cardiac - virology; Original Paper; Pandemics; Patients; Polymerase chain reaction; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Viral diseases; COVID-19; Myocarditis; Cardiac autopsy study; Necrosis; Myocardial injury

Objective Despite growing evidence about myocardial injury in hospitalized COronaVIrus Disease 2019 (COVID-19) patients, the mechanism behind this injury is only poorly understood and little is known about its association with SARS-CoV-2-mediated myocarditis. Furthermore, definite evidence of the pr...