Correlation of Pharmacokinetic Parameters with Serum Vancomycin Concentration in Elderly Patients with Malignancies

• Published in: YAKUGAKU ZASSHI Vol. 130; no. 1; pp. 69 - 73
• Main Authors: SADOH, Shinichi, TSUJI, Yasuhiro, TSUKAMOTO, Kazuhiro
• Format: Journal Article
• Language: English
• Published: The Pharmaceutical Society of Japan 01.01.2010
• Subjects: elderly patient; malignancy; methicillin-resistant Staphylococcus aureus; therapeutic drug monitoring; vancomycin pharmacokinetics

Vancomycin (VCM) is a glycopeptide antibiotic that is generally used to treat methicillin-resistant Staphylococcus aureus (MRSA). Recently, it has been reported that VCM clearance (CL) is significantly higher in elderly patients and infants and children with malignancies, compared with those without...