The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

• Published in: Science translational medicine Vol. 10; no. 436
• Main Authors: Krall, Jordan A, Reinhardt, Ferenc, Mercury, Oblaise A, Pattabiraman, Diwakar R, Brooks, Mary W, Dougan, Michael, Lambert, Arthur W, Bierie, Brian, Ploegh, Hidde L, Dougan, Stephanie K, Weinberg, Robert A
• Format: Journal Article
• Language: English
• Published: United States 11.04.2018
• Subjects: Animals; Biomarkers, Tumor - immunology; Biomarkers, Tumor - metabolism; Breast Neoplasms - immunology; Breast Neoplasms - metabolism; CD8-Positive T-Lymphocytes - metabolism; Cell Line, Tumor; Female; Mice; Neoplasm Metastasis - immunology; Neoplasm Recurrence, Local - immunology; Neoplasm Recurrence, Local - metabolism

Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of t...