Associations between epidermal growth factor receptor and topoisomerase II-alpha gene copy number variations, human papillomavirus positivity, and cytologic analysis in cervical cell lesions

• Published in: Indian journal of pathology & microbiology Vol. 60; no. 3; pp. 328 - 335
• Main Authors: Kaya, Işın, Sivrikoz, OyaNermin, Etlik, Özdal, Gök, Abdülkadir
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.07.2017; Wolters Kluwer Medknow Publications
• Subjects: Adult; Carcinoma - pathology; Care and treatment; Cervical cancer; Cervical cytology; Copy number variations; Cytological Techniques; Development and progression; Diagnosis; DNA Topoisomerases, Type II - genetics; DNA, Viral - analysis; EGFR gene; Epidermal growth factor receptors; Female; FISH; Gene Dosage; Gene expression; Genetic aspects; Health aspects; HPV; Humans; In Situ Hybridization, Fluorescence; Middle Aged; Papillomaviridae - isolation & purification; Papillomavirus infections; Papillomavirus Infections - complications; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; Prognosis; Receptor, Epidermal Growth Factor - genetics; TOP2A gene; Uterine Cervical Neoplasms - pathology; Volunteers; Young Adult

Cervical cancer is the second most common gynecologic cancer worldwide. Human papillomavirus (HPV) infection is a leading etiological factor in cervical carcinoma.The aim of this study was to compare HPV positivity, EGFR and TOP2A gene copy number variations and cervical cytologic findings. The stud...