Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly

• Published in: Cell research Vol. 32; no. 2; pp. 190 - 209
• Main Authors: Wang, Lei, Paudyal, Sharad C., Kang, Yuchen, Owa, Mikito, Liang, Feng-Xia, Spektor, Alexander, Knaut, Holger, Sánchez, Irma, Dynlacht, Brian D.
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2022; Nature Publishing Group
• Subjects: 42/41; 42/70; 631/80/128/1276; 631/80/128/1383; 631/80/128/1653; 631/80/386; 64/116; 82/58; Actin; Actins - metabolism; Biomedical and Life Sciences; Cancer; Cell Biology; Cell cycle; Cilia - metabolism; Cytoskeleton; Defects; Dismantling; Life Sciences; Microbalances; Microtubules; Microtubules - metabolism; Morphology; Post-translation; Protein Processing, Post-Translational; Proteins; Regulation; Roles; Satellites; Sperm; Tubulin; Tubulin - genetics; Yes-associated protein

Cytoskeletal networks play an important role in regulating nuclear morphology and ciliogenesis. However, the role of microtubule (MT) post-translational modifications in nuclear shape regulation and cilium disassembly has not been explored. Here we identified a novel regulator of the tubulin polyglu...