Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models

• Published in: Biomedicine & pharmacotherapy Vol. 137; p. 111375
• Main Authors: Lu, Xiaoguang, Lu, Linghui, Gao, Li, Wang, Yong, Wang, Wei
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.05.2021; Elsevier
• Subjects: Autophagy; Calycosin; Cardiotoxicity; Doxorubicin; Zebrafish; Zebrafish; Cardiotoxicity; Calycosin; Doxorubicin; Autophagy

Anthracyclines are highly effective chemotherapeutics for antineoplastic treatment. However, cumulative cardiotoxicity is the main side effect with poor prognosis. No mechanism-based therapy is currently available to reverse chronic anthracycline-induced cardiotoxicity (AIC) after the deterioration...