The regulation and function of CD20: an “enigma” of B-cell biology and targeted therapy

• Published in: Haematologica (Roma) Vol. 105; no. 6; pp. 1494 - 1506
• Main Authors: Pavlasova, Gabriela, Mraz, Marek
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.06.2020
• Subjects: Antibodies, Monoclonal; Antigens, CD20; B-Lymphocytes; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrimidines; Review; Rituximab

The introduction of anti-CD20 monoclonal antibodies such as rituximab, ofatumumab, or obinutuzumab improved the therapy of B-cell malignancies even though the precise physiological role and regulation of CD20 remains unclear. Furthermore, CD20 expression is highly variable between different B-cell m...