Prevalence of hepatitis C virus infection in north-eastern Brazil: a population-based study

In general, the prevalence and genotype distribution of hepatitis C virus (HCV) are estimated based on the ambulatory clinic or hospital population. In the present work, a population-based study was conducted to estimate the prevalence of HCV infection in Salvador, Brazil. A total of 1308 serum samp...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 100; no. 7; pp. 663 - 668
Main Authors Zarife, Maria Alice S., Silva, Luciano K., Silva, Maria Betânia S., Lopes, Gisele B., Barreto, Maurício L., Teixeira, Maria da Glória, Dourado, Inês, Reis, Mitermayer G.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.07.2006
Royal Society of Tropical Medicine and Hygiene
Elsevier
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Abstract In general, the prevalence and genotype distribution of hepatitis C virus (HCV) are estimated based on the ambulatory clinic or hospital population. In the present work, a population-based study was conducted to estimate the prevalence of HCV infection in Salvador, Brazil. A total of 1308 serum samples were collected from 30 ‘sentinel areas’, and the prevalence of HCV infection was determined by ELISA and confirmed by recombinant immunoblot assay and RT-PCR. The overall prevalence of HCV infection was 1.5% (20/1308). Prevalence was greater among those aged 35 years or older and those with more education. Genotype 3 was the most common (53.3%), followed by genotypes 1 (40%) and 2 (6.7%). These observations are different from those found in a prior survey of hospital and ambulatory patients in Salvador, who were most frequently infected with genotype 1, followed by genotypes 3 and 2, respectively.
AbstractList In general, the prevalence and genotype distribution of hepatitis C virus (HCV) are estimated based on the ambulatory clinic or hospital population. In the present work, a population-based study was conducted to estimate the prevalence of HCV infection in Salvador, Brazil. A total of 1308 serum samples were collected from 30 "sentinel areas", and the prevalence of HCV infection was determined by ELISA and confirmed by recombinant immunoblot assay and RT-PCR. The overall prevalence of HCV infection was 1.5% (20/1308). Prevalence was greater among those aged 35 years or older and those with more education. Genotype 3 was the most common (53.3%), followed by genotypes 1 (40%) and 2 (6.7%). These observations are different from those found in a prior survey of hospital and ambulatory patients in Salvador, who were most frequently infected with genotype 1, followed by genotypes 3 and 2, respectively.
Author Silva, Luciano K.
Teixeira, Maria da Glória
Lopes, Gisele B.
Reis, Mitermayer G.
Silva, Maria Betânia S.
Dourado, Inês
Zarife, Maria Alice S.
Barreto, Maurício L.
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  givenname: Maria da Glória
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Issue 7
Keywords Population-based study
Brazil
Genotype
HCV
Hepatitis C virus
Prevalence
Hepatic disease
Epidemiology
Infection
Virus
Viral disease
Digestive diseases
Tropical medicine
Flaviviridae
Hepacivirus
Viral hepatitis C
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Snippet In general, the prevalence and genotype distribution of hepatitis C virus (HCV) are estimated based on the ambulatory clinic or hospital population. In the...
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SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral - blood
Biological and medical sciences
Brazil
Brazil - epidemiology
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay - methods
Female
Genotype
HCV
Hepacivirus - genetics
Hepatitis C - epidemiology
Hepatitis C - genetics
Hepatitis C - immunology
Hepatitis C virus
Human viral diseases
Humans
Immunoblotting - methods
Infant
Infectious diseases
Male
Medical sciences
Middle Aged
Population Surveillance - methods
Population-based study
Prevalence
Retrospective Studies
RNA, Viral - analysis
Seroepidemiologic Studies
Urban Health
Viral diseases
Viral hepatitis
Title Prevalence of hepatitis C virus infection in north-eastern Brazil: a population-based study
URI https://dx.doi.org/10.1016/j.trstmh.2005.09.009
https://api.istex.fr/ark:/67375/HXZ-00B07GSQ-Z/fulltext.pdf
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Volume 100
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