Site-1 protease controls osteoclastogenesis by mediating LC3 transcription

• Published in: Cell death and differentiation Vol. 28; no. 6; pp. 2001 - 2018
• Main Authors: Zheng, Zeyu, Zhang, Xuyang, Huang, Bao, Liu, Junhui, Wei, Xiaoan, Shan, Zhi, Wu, Hao, Feng, Zhenhua, Chen, Yilei, Fan, Shunwu, Zhao, Fengdong, Chen, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2021; Nature Publishing Group
• Subjects: 13/51; 13/95; 14/19; 38/109; 38/77; 42/89; 45/15; 631/443; 631/80/39/2345; 64/110; 96/31; 96/35; Adenoviruses; Animals; Apoptosis; Arthritis; Autophagy; Biochemistry; Biomedical and Life Sciences; Bone dysplasia; Bone loss; Bone marrow; Bone remodeling; Cell Biology; Cell Cycle Analysis; Cell Differentiation; Endoplasmic reticulum; Golgi apparatus; Humans; Immunoprecipitation; Inflammation; Kinases; Kyphosis; Life Sciences; Lipid metabolism; Lipopolysaccharides; Membrane proteins; Mice; Microtubule-Associated Proteins - metabolism; Monocytes; Osteoarthritis; Osteoclastogenesis; Osteoclasts - metabolism; Osteoporosis; Osteosclerosis; Ovariectomy; Phagocytosis; Proprotein Convertases - metabolism; Protein expression; Proteinase; Proteins; Scoliosis; Serine Endopeptidases - metabolism; Signal Transduction; Skeleton; Stem Cells; Transcription factors; Transfection

Site-1 protease (S1P) is a Golgi-located protein that activates unique membrane-bound latent transcription factors, and it plays an indispensable role in endoplasmic reticulum stress, lipid metabolism, inflammatory response and lysosome function. A patient with S1P mutation exhibits severe skeletal...