Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy

• Published in: International journal of radiation oncology, biology, physics Vol. 81; no. 5; pp. 1236 - 1243
• Main Authors: Moran, Meena S., M.D, Yang, Qifeng, M.D., Ph.D, Goyal, Sharad, M.D, Harris, Lyndsay, M.D, Chung, Gina, M.D, Haffty, Bruce G., M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2011; Elsevier
• Subjects: Adult; African Continental Ancestry Group; Aged; Aged, 80 and over; Analysis of Variance; ANGIOGENESIS; Biological and medical sciences; Biomarkers, Tumor - analysis; Breast cancer; Breast Neoplasms - chemistry; Breast Neoplasms - ethnology; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Breast-conserving therapy; DIAGNOSIS; Disease-Free Survival; ESTROGENS; European Continental Ancestry Group; EVALUATION; Female; Follow-Up Studies; GROWTH FACTORS; Gynecology. Andrology. Obstetrics; HAZARDS; Hematology, Oncology and Palliative Medicine; Humans; Local relapse; Mammary gland diseases; MAMMARY GLANDS; Mastectomy, Segmental; Medical sciences; METASTASES; Middle Aged; Molecular markers; MULTIVARIATE ANALYSIS; Neoplasm Recurrence, Local - chemistry; Neoplasm Recurrence, Local - ethnology; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; NEOPLASMS; PARAFFIN; PATIENTS; PROGESTERONE; Prognosis; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; Radiotherapy; RECEPTORS; RECOMMENDATIONS; THERAPY; Tissue Array Analysis - methods; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - analysis; VEGF; Local relapse; Molecular markers; Breast cancer; Breast-conserving therapy; Vascular endothelial growth factor; VEGF; Human; Relapse; Breast disease; Prognosis; Genetic marker; Biological marker; Early stage; Malignant tumor; Molecular marker; Mammary gland diseases; Cancerology; Vascular endothelium growth factor; Treatment; Breast; Mammary gland; Cancer

Purpose Vascular endothelial growth factor (VEGF) is an important protein involved in the process of angiogenesis that has been found to correlate with relapse-free and overall survival in breast cancer, predominantly in locally advanced and metastatic disease. A paucity of data is available on the...