Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues

• Published in: Scientific reports Vol. 8; no. 1; pp. 11456 - 12
• Main Authors: Tiong, Khong-Loon, Yeang, Chen-Hsiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.07.2018; Nature Publishing Group
• Subjects: 631/114/2403; 631/67/69; Cancer; Cell adhesion; Cell proliferation; Chromatin; DNA repair; Gene expression; Gene frequency; Gene set enrichment analysis; Genomes; Humanities and Social Sciences; multidisciplinary; Mutation; Protein interaction; Science; Science (multidisciplinary); Tumors

Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell proliferation and cell adhesion, yet their mutations are often confined to specific cancer types. To resolve this paradox, we explained mutation frequencies of selected genes across tumor types with four fea...