Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2

• Published in: Acta pharmacologica Sinica Vol. 43; no. 1; pp. 76 - 85
• Main Authors: Zhang, Ya-li, Zhang, Wen-xin, Yan, Jue-qian, Tang, Ye-lin, Jia, Wen-jing, Xu, Zheng-wei, Xu, Ming-jiang, Chattipakorn, Nipon, Wang, Yi, Feng, Jian-peng, Liu, Zhi-guo, Liang, Guang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.01.2022; Nature Publishing Group
• Subjects: Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Administration, Oral; Animal models; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; Cells, Cultured; Chalcones - administration & dosage; Chalcones - pharmacology; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Immunology; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Inflammatory diseases; Internal Medicine; Lipopolysaccharides; Lungs; Lymphocyte Antigen 96 - antagonists & inhibitors; Lymphocyte Antigen 96 - metabolism; Macrophages; Male; Medical Microbiology; Mice; Mice, Inbred C57BL; Molecular Structure; NF-κB protein; Oral administration; Permeability; Pharmaceutical sciences; Pharmacology/Toxicology; Phosphorylation; Respiratory distress syndrome; Respiratory failure; Structure-Activity Relationship; Surface plasmon resonance; TLR4 protein; Toll-Like Receptor 4 - antagonists & inhibitors; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Vaccine; myeloid differentiation 2; lipopolysaccharide; inflammation; chalcone derivatives; mouse peritoneal macrophages; acute lung injury

Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are known as the common causes of respiratory failure in critically ill patients. Myeloid differentiation 2 (MD2), a co-receptor of toll like receptor 4 (TLR4), plays an important role in LPS-induced ALI in mice....