Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1

• Published in: Cancer discovery Vol. 12; no. 7; pp. 1742 - 1759
• Main Authors: Yuan, Xiangliang, Duan, Yimin, Xiao, Yi, Sun, Kai, Qi, Yutao, Zhang, Yuan, Ahmed, Zamal, Moiani, Davide, Yao, Jun, Li, Hongzhong, Zhang, Lin, Yuzhalin, Arseniy E., Li, Ping, Zhang, Chenyu, Badu-Nkansah, Akosua, Saito, Yohei, Liu, Xianghua, Kuo, Wen-Ling, Ying, Haoqiang, Sun, Shao-Cong, Chang, Jenny C., Tainer, John A., Yu, Dihua
• Format: Journal Article
• Language: English
• Published: United States 06.07.2022
• Subjects: Animals; Cancer Vaccines - therapeutic use; Dendritic Cells; Immunotherapy; Mice; Neoplasms - drug therapy; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Vitamin E - metabolism

Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint therapy (ICT), are unknown. Surprisingly, our analyses of electronic health records revealed that ICT-treated patients with...