Association between single nucleotide polymorphisms within HLA region and disease relapse for patients with hematopoietic stem cell transplantation

• Published in: Scientific reports Vol. 9; no. 1; pp. 13731 - 8
• Main Authors: Chen, Ding-Ping, Chang, Su-Wei, Wang, Po-Nan, Hus, Fang-Ping, Tseng, Ching-Ping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.09.2019; Nature Publishing Group
• Subjects: 45/23; 45/77; 692/308/2056; 692/4017; Acute myeloid leukemia; Adolescent; Adult; Base pairs; Child; Child, Preschool; DOA gene; Donors; Female; Graft vs Host Disease - genetics; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Histocompatibility antigen HLA; HLA Antigens - genetics; Humanities and Social Sciences; Humans; Leukemia; Leukemia, Myeloid, Acute - genetics; Lymphatic leukemia; Lymphotoxin; Male; Middle Aged; multidisciplinary; Myeloid leukemia; Notch4 protein; Polymorphism, Single Nucleotide - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Promoter Regions, Genetic - genetics; Recurrence; RING1 gene; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Stem cell transplantation; Stem cells; Transplantation; Transplantation, Homologous - methods; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-50111-5

Disease relapse occurs in patients with leukemia even hematopoietic stem cell transplantation (HSCT) was performed with human leukocyte antigen (HLA)-matched donors. As revealed previously by Petersdorf et al ., there are nine single nucleotide polymorphisms (SNPs) located in the HLA region that pot...