Palliative Radiation Therapy for Head and Neck Cancers

Patients with advanced head and neck cancers who are not eligible for curative treatment represent a challenging cohort of patients to manage given the complexity and severity of their presenting symptoms. Palliative radiation therapy, along with other systemic and surgical measures, has the potenti...

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Published inInternational journal of radiation oncology, biology, physics Vol. 105; no. 2; pp. 254 - 266
Main Authors Grewal, Amardeep S., Jones, Joshua, Lin, Alexander
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2019
Subjects
Cancer Pain - drug therapy
Cancer Pain - radiotherapy
Clinical Trials as Topic
Deglutition Disorders - therapy
Dose Fractionation, Radiation
Episode of Care
Head and Neck Neoplasms - complications
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - radiotherapy
Humans
Immunotherapy - methods
Oropharyngeal Neoplasms - virology
Palliative Care - methods
Papillomavirus Infections - complications
Physical Functional Performance
Prognosis
Proton Therapy
Radiation-Sensitizing Agents - therapeutic use
Radiotherapy - methods
Radiotherapy Dosage
Re-Irradiation
Treatment Outcome
Xerostomia - etiology
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Abstract Patients with advanced head and neck cancers who are not eligible for curative treatment represent a challenging cohort of patients to manage given the complexity and severity of their presenting symptoms. Palliative radiation therapy, along with other systemic and surgical measures, has the potential to significantly improve the quality of life of such patients. There is little high-level evidence and a lack of consensus to direct the selection of an optimal palliative radiation regimen. An ideal palliative radiation regimen should alleviate symptoms secondary to the cancer with minimal treatment toxicity and side effects while improving a patient's quality of life. This review presents the treatment approaches, outcomes, and toxicities associated with different radiation regimens and proposes a multidisciplinary framework for the selection of an individualized treatment regimen for patients that centers around patient prognosis, goals of care, logistics of treatment, and the availability of other surgical and systemic therapies.
AbstractList Patients with advanced head and neck cancers who are not eligible for curative treatment represent a challenging cohort of patients to manage given the complexity and severity of their presenting symptoms. Palliative radiation therapy, along with other systemic and surgical measures, has the potential to significantly improve the quality of life of such patients. There is little high-level evidence and a lack of consensus to direct the selection of an optimal palliative radiation regimen. An ideal palliative radiation regimen should alleviate symptoms secondary to the cancer with minimal treatment toxicity and side effects while improving a patient's quality of life. This review presents the treatment approaches, outcomes, and toxicities associated with different radiation regimens and proposes a multidisciplinary framework for the selection of an individualized treatment regimen for patients that centers around patient prognosis, goals of care, logistics of treatment, and the availability of other surgical and systemic therapies.
Patients with advanced head and neck cancers who are not eligible for curative treatment represent a challenging cohort of patients to manage given the complexity and severity of their presenting symptoms. Palliative radiation therapy, along with other systemic and surgical measures, has the potential to significantly improve the quality of life of such patients. There is little high-level evidence and a lack of consensus to direct the selection of an optimal palliative radiation regimen. An ideal palliative radiation regimen should alleviate symptoms secondary to the cancer with minimal treatment toxicity and side effects while improving a patient's quality of life. This review presents the treatment approaches, outcomes, and toxicities associated with different radiation regimens and proposes a multidisciplinary framework for the selection of an individualized treatment regimen for patients that centers around patient prognosis, goals of care, logistics of treatment, and the availability of other surgical and systemic therapies.
Author Grewal, Amardeep S.
Lin, Alexander
Jones, Joshua
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Snippet Patients with advanced head and neck cancers who are not eligible for curative treatment represent a challenging cohort of patients to manage given the...
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SubjectTerms Cancer Pain - drug therapy
Cancer Pain - radiotherapy
Clinical Trials as Topic
Deglutition Disorders - therapy
Dose Fractionation, Radiation
Episode of Care
Head and Neck Neoplasms - complications
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - radiotherapy
Humans
Immunotherapy - methods
Oropharyngeal Neoplasms - virology
Palliative Care - methods
Papillomavirus Infections - complications
Physical Functional Performance
Prognosis
Proton Therapy
Radiation-Sensitizing Agents - therapeutic use
Radiotherapy - methods
Radiotherapy Dosage
Re-Irradiation
Treatment Outcome
Xerostomia - etiology
Title Palliative Radiation Therapy for Head and Neck Cancers
URI https://dx.doi.org/10.1016/j.ijrobp.2019.05.024
https://www.ncbi.nlm.nih.gov/pubmed/31128145
https://search.proquest.com/docview/2232116195
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