Rapid antibiotic susceptibility testing of bacteria from patients’ blood via assaying bacterial metabolic response with surface-enhanced Raman spectroscopy

• Published in: Scientific reports Vol. 10; no. 1; p. 12538
• Main Authors: Han, Yin-Yi, Lin, Yi-Chun, Cheng, Wei-Chih, Lin, Yu-Tzu, Teng, Lee-Jene, Wang, Juen-Kai, Wang, Yuh-Lin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.07.2020; Nature Publishing Group
• Subjects: 631/1647/2234; 639/624/1107/527/1821; 639/638/440/527/1821; 639/925/357/354; 639/925/927/1021; 639/925/927/356; 639/925/927/511; 639/925/930/527/1821; Animals; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Bacteria; Bacteria - drug effects; Bacteria - metabolism; Biomarkers - metabolism; Blood; Drug resistance; E coli; Escherichia coli - drug effects; Goats; Gram-negative bacteria; Humanities and Social Sciences; Humans; Infections; Metabolic response; Metabolism; Microbial Sensitivity Tests; multidisciplinary; Patients; Public health; Raman spectroscopy; ROC Curve; Science; Science (multidisciplinary); Signal Processing, Computer-Assisted; Spectroscopy; Spectrum analysis; Spectrum Analysis, Raman; Staphylococcus aureus - drug effects; Susceptibility

Blood stream infection is one of the major public health issues characterized with high cost and high mortality. Timely effective antibiotics usage to control infection is crucial for patients’ survival. The standard microbiological diagnosis of infection however can last days. The delay in accurate...