Antiparasitic activity of synthetic curcumin monocarbonyl analogues against Trichomonas vaginalis

• Published in: Biomedicine & pharmacotherapy Vol. 111; pp. 367 - 377
• Main Authors: Carapina da Silva, Caroline, Pacheco, Bruna Silveira, das Neves, Raquel Nascimento, Dié Alves, Mirna Samara, Sena-Lopes, Ângela, Moura, Sidnei, Borsuk, Sibele, de Pereira, Claudio Martin Pereira
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.03.2019; Elsevier
• Subjects: Antiparasitic; Arylideneketones; C5-curcuminoids; Dibenzylideneacetone; Metronidazole; Antiparasitic; Dibenzylideneacetone; Metronidazole; Arylideneketones; C5-curcuminoids

[Display omitted] •Curcumin monocarbonyl analogues were synthesized in good yields by easy protocols.•Three analogues inhibited Trichomonas vaginalis growth similarly to metronidazole.•Curcumin analogues eradicated T. vaginalis growth within 24 hrs.•Analogue 3e did not induce any level of cytotoxici...