Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring

• Published in: GeroScience Vol. 44; no. 2; pp. 719 - 729
• Main Authors: Gunn, Sophia, Wainberg, Michael, Song, Zeyuan, Andersen, Stacy, Boudreau, Robert, Feitosa, Mary F., Tan, Qihua, Montasser, May E., O’Connell, Jeffrey R., Stitziel, Nathan, Price, Nathan, Perls, Thomas, Schork, Nicholas J., Sebastiani, Paola
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2022; Springer Nature B.V
• Subjects: Aged, 80 and over; Aging; Alzheimer Disease - genetics; Alzheimer's disease; Biomedical and Life Sciences; Cardiovascular disease; Cell Biology; Cognitive ability; Coronary artery; Dementia; Dementia disorders; Environmental factors; Genetic disorders; Genetic Predisposition to Disease - genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Geriatrics; Geriatrics/Gerontology; Health risk assessment; Heart diseases; Humans; Life Sciences; Longevity; Molecular Medicine; Multifactorial Inheritance - genetics; Neurodegenerative diseases; Original; Original Article; Polygenic inheritance; Regression analysis; Risk assessment; Risk Factors; Long-lived families; polygenic risk scores; Exceptional Longevity

A surprising and well-replicated result in genetic studies of human longevity is that centenarians appear to carry disease-associated variants in numbers similar to the general population. With the proliferation of large genome-wide association studies (GWAS) in recent years, investigators have turn...