Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance

• Published in: Metabolites Vol. 14; no. 8; p. 411
• Main Authors: Mathioudaki, Argyri, Fanni, Giovanni, Eriksson, Jan W, Pereira, Maria J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.07.2024; MDPI
• Subjects: Adipocytes; Adipose tissue; Adipose tissues; Amino acids; Body fat; Body mass index; Branched chain amino acids; Carbohydrates; Correlation analysis; Dextrose; Diabetes; Diabetes mellitus (non-insulin dependent); Energy metabolism; Fatty acids; Glucose; Glucose metabolism; glucose uptake; Health aspects; Hypoglycemic agents; Insulin resistance; insulin sensitivity; Intermediates; Metabolism; Metabolites; Metabolomics; Obesity; Peptides; Physiological aspects; Principal components analysis; Public health; Therapeutic targets; Tricarboxylic acid cycle; Type 2 diabetes; Unsaturated fatty acids; United States > US; adipose tissue; insulin sensitivity; type 2 diabetes; glucose uptake; metabolomics

The global prevalence of Type 2 Diabetes (T2D) poses significant public health challenges due to its associated severe complications. Insulin resistance is central to T2D pathophysiology, particularly affecting adipose tissue function. This cross-sectional observational study investigates metabolic...