Inflammasome formation in the lungs of patients with fatal COVID-19

• Published in: Inflammation research Vol. 70; no. 1; pp. 7 - 10
• Main Authors: Toldo, Stefano, Bussani, Rossana, Nuzzi, Vincenzo, Bonaventura, Aldo, Mauro, Adolfo G., Cannatà, Antonio, Pillappa, Raghavendra, Sinagra, Gianfranco, Nana-Sinkam, Patrick, Sime, Patricia, Abbate, Antonio
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2021; Springer Nature B.V
• Subjects: Adult; Aged; Allergology; Apoptosis; Autopsy; Biomedical and Life Sciences; Biomedicine; CARD Signaling Adaptor Proteins - analysis; CARD Signaling Adaptor Proteins - metabolism; Caspase 1 - analysis; Caspase 1 - metabolism; Caspase-1; Coronaviruses; COVID-19; COVID-19 - pathology; Cytokine Release Syndrome - metabolism; Cytokine Release Syndrome - pathology; Cytokines; Deregulation; Dermatology; Fatalities; Female; Heart Arrest - etiology; Humans; Immunology; Infections; Inflammasomes; Inflammation; Interleukin 1; Leukocytes; Leukocytes - pathology; Lung - pathology; Lungs; Macrophages; Male; Mechanical ventilation; Middle Aged; Neurology; NLR Family, Pyrin Domain-Containing 3 Protein - analysis; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Paraffin; Paraffins; Pharmacology/Toxicology; Pneumonia; Pneumonia, Viral - etiology; Pneumonia, Viral - pathology; Proteins; Respiratory distress syndrome; Respiratory Distress Syndrome - etiology; Respiratory Distress Syndrome - pathology; Rheumatology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Short Communication; Ventilation; Viral diseases; COVID-19; SARS-CoV-2; Cytokine release syndrome; NLRP3 inflammasome; IL-1

Objective The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2, triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome-mediated release of interleukin-1 family cytokines is important in hyper-inflammatory syndromes, like happens in SARS-CoV-2-mediated cyt...