Astrogliosis as a therapeutic target for neurodegenerative diseases

• Published in: Neuroscience letters Vol. 565; pp. 59 - 64
• Main Authors: Colangelo, Anna Maria, Alberghina, Lilia, Papa, Michele
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 17.04.2014
• Subjects: Animals; Astrocytes - pathology; Astrocytes - transplantation; Brain - drug effects; Brain - pathology; Brain homeostasis; Drug Discovery; Gliosis - pathology; Gliosis - therapy; Glutamic Acid - metabolism; Humans; Inflammation - drug therapy; Inflammation - pathology; Nerve Growth Factors - metabolism; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - therapy; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurotrophins; Reactive astrogliosis; Signal Transduction; Synapses - physiology; Systems Biology; Reactive astrogliosis; NO; Neuroprotection; TNFα; JNK; ALS; CNS; Iba1; COX-1/2; LPS; GLAST; PI3K; EAAT1/2; NMDA; EAAC1; Brain homeostasis; Neurotrophins; GSH; vGLUT1; AD; BDNF; MS; MMPs; STAT3; EAE; PLCγ; MAPK; NGF; IP3; i.t; GFAP; vGAT; PD; Ca2; Systems biology; GlyT-1; GABA; SCI; HD; ATP; BB14; GLT-1

•We briefly review the role of astrocytes in brain function.•We review the main pathways in astrocytic dysfunction.•We focus on astroglial-specific targets for clinical management of neurodegenerative disorders.•We describe the usefulness of a systems biology approach in drug discovery for neurodege...