Astrogliosis as a therapeutic target for neurodegenerative diseases

•We briefly review the role of astrocytes in brain function.•We review the main pathways in astrocytic dysfunction.•We focus on astroglial-specific targets for clinical management of neurodegenerative disorders.•We describe the usefulness of a systems biology approach in drug discovery for neurodege...

Full description

Saved in:

Bibliographic Details
Published in	Neuroscience letters Vol. 565; pp. 59 - 64
Main Authors	Colangelo, Anna Maria, Alberghina, Lilia, Papa, Michele
Format	Journal Article
Language	English
Published	Ireland Elsevier Ireland Ltd 17.04.2014
Subjects	Animals Astrocytes - pathology Astrocytes - transplantation Brain - drug effects Brain - pathology Brain homeostasis Drug Discovery Gliosis - pathology Gliosis - therapy Glutamic Acid - metabolism Humans Inflammation - drug therapy Inflammation - pathology Nerve Growth Factors - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotrophins Reactive astrogliosis Signal Transduction Synapses - physiology Systems Biology Reactive astrogliosis NO Neuroprotection TNFα JNK ALS CNS Iba1 COX-1/2 LPS GLAST PI3K EAAT1/2 NMDA EAAC1 Brain homeostasis Neurotrophins GSH vGLUT1 AD BDNF MS MMPs STAT3 EAE PLCγ MAPK NGF IP3 i.t GFAP vGAT PD Ca2 Systems biology GlyT-1 GABA SCI HD ATP BB14 GLT-1
Online Access	Get full text

Cover

Loading…

Abstract	•We briefly review the role of astrocytes in brain function.•We review the main pathways in astrocytic dysfunction.•We focus on astroglial-specific targets for clinical management of neurodegenerative disorders.•We describe the usefulness of a systems biology approach in drug discovery for neurodegenerative disorders. Chronic neurodegenerative diseases represent major unmet needs for therapeutic interventions. Recently, the neurocentric view of brain function and disease has been challenged by a great number of evidence supporting the physiopathological potential of neuroglia. Astrocytes, in particular, play a pivotal role in brain homeostasis as they actively participate in neuronal metabolism, synaptic plasticity and neuroprotection. Furthermore, they are intrinsic components of brain responses to toxic and traumatic insults through complex processes involving several molecular and functional alterations that may lead to disruption of brain homeostasis and connectivity. This review provides a brief overview of current knowledge of astrocyte functions in the brain, and focuses on some glial-specific pathways involved in astrocytic dysfunction that might be effective therapeutic targets for clinical management of neurodegenerative disorders.
AbstractList	•We briefly review the role of astrocytes in brain function.•We review the main pathways in astrocytic dysfunction.•We focus on astroglial-specific targets for clinical management of neurodegenerative disorders.•We describe the usefulness of a systems biology approach in drug discovery for neurodegenerative disorders. Chronic neurodegenerative diseases represent major unmet needs for therapeutic interventions. Recently, the neurocentric view of brain function and disease has been challenged by a great number of evidence supporting the physiopathological potential of neuroglia. Astrocytes, in particular, play a pivotal role in brain homeostasis as they actively participate in neuronal metabolism, synaptic plasticity and neuroprotection. Furthermore, they are intrinsic components of brain responses to toxic and traumatic insults through complex processes involving several molecular and functional alterations that may lead to disruption of brain homeostasis and connectivity. This review provides a brief overview of current knowledge of astrocyte functions in the brain, and focuses on some glial-specific pathways involved in astrocytic dysfunction that might be effective therapeutic targets for clinical management of neurodegenerative disorders. Chronic neurodegenerative diseases represent major unmet needs for therapeutic interventions. Recently, the neurocentric view of brain function and disease has been challenged by a great number of evidence supporting the physiopathological potential of neuroglia. Astrocytes, in particular, play a pivotal role in brain homeostasis as they actively participate in neuronal metabolism, synaptic plasticity and neuroprotection. Furthermore, they are intrinsic components of brain responses to toxic and traumatic insults through complex processes involving several molecular and functional alterations that may lead to disruption of brain homeostasis and connectivity. This review provides a brief overview of current knowledge of astrocyte functions in the brain, and focuses on some glial-specific pathways involved in astrocytic dysfunction that might be effective therapeutic targets for clinical management of neurodegenerative disorders.
Author	Papa, Michele Colangelo, Anna Maria Alberghina, Lilia
Author_xml	– sequence: 1 givenname: Anna Maria surname: Colangelo fullname: Colangelo, Anna Maria email: annamaria.colangelo@unimib.it organization: Laboratory of Neuroscience “R. Levi-Montalcini”, Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy – sequence: 2 givenname: Lilia surname: Alberghina fullname: Alberghina, Lilia organization: Laboratory of Neuroscience “R. Levi-Montalcini”, Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy – sequence: 3 givenname: Michele surname: Papa fullname: Papa, Michele organization: Laboratory of Morfology of Neural Networks, Department of Medicina Pubblica Clinica e Preventiva, Second University of Napoli, Napoli, Italy
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24457173$$D View this record in MEDLINE/PubMed
BookMark	eNp9kFtLAzEQhYNU7EX_gcj-gV1z283ui1CKNyj4os8hm0xqSrspSVrw35uy6qNwYB7mnDnDN0eTwQ-A0C3BFcGkud9WAxx3kCqKCa8wyeIXaEZaQUvRCTpBM8wwL1nH8RTNY9xijGtS8ys0pZzXggg2Q6tlTMFvds5HFwuVVaRPCOoAx-R0kVTYQCqsD0VuC97ABoa8Tu4EhXERVIR4jS6t2kW4-ZkL9PH0-L56Kddvz6-r5brUXPBUtiC0bixVpm854Z3BrLHa0lphRsHWLdBO057ZhqiG9ERbq2vbcA3QtaYWbIH4eFcHH2MAKw_B7VX4kgTLMxO5lSMTeWYiMcniOXY3xg7Hfg_mL_QLIRseRgPk508OgozawaDBuAA6SePd_w3f2L54MQ
CitedBy_id	crossref_primary_10_1007_s12035_016_0193_8 crossref_primary_10_1007_s12257_018_0207_7 crossref_primary_10_1002_advs_201700897 crossref_primary_10_1007_s12975_020_00809_w crossref_primary_10_1016_j_neuropharm_2016_12_017 crossref_primary_10_2174_1570159X20666220830112408 crossref_primary_10_1007_s11481_016_9724_3 crossref_primary_10_1093_jnen_nlw032 crossref_primary_10_3390_medsci8010007 crossref_primary_10_3389_fnbeh_2020_00018 crossref_primary_10_3390_cells13030286 crossref_primary_10_1016_j_neures_2020_07_011 crossref_primary_10_1093_ijnp_pyw021 crossref_primary_10_1136_jnnp_2019_321954 crossref_primary_10_3390_biomedicines8110479 crossref_primary_10_1002_syn_22025 crossref_primary_10_3389_fphar_2020_584533 crossref_primary_10_3389_fnmol_2014_00050 crossref_primary_10_1007_s12035_018_0875_5 crossref_primary_10_3390_nu11040753 crossref_primary_10_1371_journal_pone_0152750 crossref_primary_10_1016_j_bbr_2023_114329 crossref_primary_10_1016_j_neulet_2019_134532 crossref_primary_10_1016_j_jchemneu_2017_02_008 crossref_primary_10_1016_j_neulet_2015_12_057 crossref_primary_10_1093_braincomms_fcac210 crossref_primary_10_1371_journal_pone_0119912 crossref_primary_10_1038_s41598_019_45129_8 crossref_primary_10_3390_jpm10030116 crossref_primary_10_1016_j_pneurobio_2017_03_005 crossref_primary_10_1016_j_jconrel_2016_09_011 crossref_primary_10_1159_000495078 crossref_primary_10_1007_s12035_017_0713_1 crossref_primary_10_1016_j_exer_2019_107742 crossref_primary_10_1038_srep31581 crossref_primary_10_1016_j_nbd_2015_05_003 crossref_primary_10_1016_j_exer_2018_11_005 crossref_primary_10_1192_j_eurpsy_2019_13 crossref_primary_10_1016_j_brainres_2014_09_008 crossref_primary_10_3389_fnagi_2016_00075 crossref_primary_10_1016_j_neulet_2014_07_055 crossref_primary_10_3390_md20040258 crossref_primary_10_3389_fendo_2016_00010 crossref_primary_10_1016_j_drudis_2018_01_011 crossref_primary_10_3389_fnins_2019_00854 crossref_primary_10_1007_s11357_014_9703_7 crossref_primary_10_1016_j_neuropharm_2020_108173 crossref_primary_10_3389_fphar_2021_735165 crossref_primary_10_1002_alz_12447 crossref_primary_10_1186_1423_0127_21_60 crossref_primary_10_1016_j_neunet_2015_01_005 crossref_primary_10_1007_s12035_017_0630_3 crossref_primary_10_1080_21691401_2018_1446019 crossref_primary_10_1186_s12974_018_1114_8 crossref_primary_10_1002_brb3_1110 crossref_primary_10_1016_j_preteyeres_2017_08_002 crossref_primary_10_1111_gbb_12701 crossref_primary_10_1016_j_neuroscience_2020_09_051 crossref_primary_10_1016_j_yfrne_2018_09_001 crossref_primary_10_1038_s41598_020_70213_9 crossref_primary_10_1007_s12031_016_0757_0 crossref_primary_10_3233_RNN_150591 crossref_primary_10_1016_j_neures_2016_08_003 crossref_primary_10_3233_JAD_220318 crossref_primary_10_1016_j_ibneur_2022_12_003 crossref_primary_10_1111_bdi_12447 crossref_primary_10_1111_jnc_13399 crossref_primary_10_1177_2633105520947081 crossref_primary_10_3390_antib12040081 crossref_primary_10_1016_j_neuroscience_2015_01_003 crossref_primary_10_1177_1073858420966276 crossref_primary_10_1088_1748_605X_ab0d69 crossref_primary_10_1186_s12974_022_02573_0 crossref_primary_10_1212_WNL_0000000000209418 crossref_primary_10_3389_fnins_2022_837390 crossref_primary_10_5966_sctm_2015_0170 crossref_primary_10_1111_gtc_12535 crossref_primary_10_1080_17435390_2017_1388864 crossref_primary_10_1016_j_nbd_2024_106410 crossref_primary_10_1186_s40035_023_00388_4 crossref_primary_10_1016_j_pneurobio_2016_03_010 crossref_primary_10_3389_fncel_2014_00211 crossref_primary_10_1016_j_brainresbull_2014_10_002 crossref_primary_10_1016_j_biopsych_2017_09_021 crossref_primary_10_1152_physrev_00041_2013 crossref_primary_10_15252_emmm_202012724 crossref_primary_10_1016_j_wneu_2023_09_071 crossref_primary_10_1007_s12264_021_00705_9 crossref_primary_10_1371_journal_pbio_3002607 crossref_primary_10_1016_j_nbd_2015_06_010 crossref_primary_10_3389_fnagi_2018_00372 crossref_primary_10_1007_s00702_017_1792_x crossref_primary_10_1002_jbt_23471 crossref_primary_10_1016_j_pharmthera_2019_06_008 crossref_primary_10_3390_antiox9070630 crossref_primary_10_1016_j_npep_2023_102385 crossref_primary_10_3390_ijms241210366 crossref_primary_10_3389_fncel_2015_00495 crossref_primary_10_3389_fneur_2021_663407 crossref_primary_10_1016_j_jphs_2017_10_004 crossref_primary_10_1016_j_biopsych_2015_12_022 crossref_primary_10_1038_s41598_022_13173_6 crossref_primary_10_1111_ner_12576 crossref_primary_10_1155_2015_135342 crossref_primary_10_1155_2019_8056904 crossref_primary_10_3389_fpsyt_2021_682056 crossref_primary_10_1016_j_psyneuen_2017_03_006 crossref_primary_10_1016_j_neuint_2015_10_006 crossref_primary_10_1016_j_phymed_2015_06_005 crossref_primary_10_1038_s41398_020_01137_1 crossref_primary_10_1002_dad2_12291 crossref_primary_10_1089_ten_tea_2016_0103 crossref_primary_10_3390_cells11091428 crossref_primary_10_1186_1743_422X_11_126 crossref_primary_10_3389_fnins_2018_00546 crossref_primary_10_3390_life12111720 crossref_primary_10_1007_s11062_019_09820_w crossref_primary_10_1155_2018_4160247 crossref_primary_10_1093_braincomms_fcad325 crossref_primary_10_1016_j_yexmp_2015_11_005
Cites_doi	10.1016/j.mcn.2006.11.005 10.1186/1752-0509-6-52 10.1016/j.jalz.2011.03.012 10.1038/nrn3071 10.1111/j.1471-4159.2006.03921.x 10.1002/jnr.22665 10.1007/s11302-012-9300-0 10.1242/jeb.02208 10.1002/glia.20849 10.1038/nm1425 10.1002/j.1532-2149.2012.00255.x 10.1111/j.1471-4159.2012.07664.x 10.4049/jimmunol.168.8.4070 10.1016/S0896-6273(00)80086-0 10.1523/JNEUROSCI.1508-04.2004 10.1016/j.nbd.2010.11.012 10.1093/aje/kwm260 10.1016/j.cell.2010.02.016 10.1016/j.biotechadv.2011.05.008 10.1056/NEJM199205283262204 10.1007/s11064-006-9270-0 10.1186/1471-2202-7-S1-S2 10.1002/glia.20857 10.1002/jnr.10671 10.1007/s00401-009-0619-8 10.1016/j.bbamcr.2006.01.005 10.1016/j.neuint.2011.10.017 10.1186/1752-0509-6-132 10.4049/jimmunol.0802954 10.1016/S0304-3940(01)02098-5 10.1523/JNEUROSCI.5201-07.2008 10.1038/gt.2010.71 10.1016/j.chembiol.2005.06.015 10.1007/s10571-009-9430-2 10.1016/j.biotechadv.2011.06.016 10.1038/nature03180 10.1007/s00259-009-1103-3 10.3389/fphar.2012.00139 10.1038/nn.2210
ContentType	Journal Article
Copyright	2014 The Authors Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
Copyright_xml	– notice: 2014 The Authors – notice: Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
DBID	6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION
DOI	10.1016/j.neulet.2014.01.014
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef
DatabaseTitleList	MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Anatomy & Physiology
EISSN	1872-7972
EndPage	64
ExternalDocumentID	10_1016_j_neulet_2014_01_014 24457173 S030439401400041X
Genre	Research Support, Non-U.S. Gov't Journal Article Review
GroupedDBID	--- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 53G 5RE 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPCBC SSN SSZ T5K WH7 YCJ ~G- AAXKI AKRWK CGR CUY CVF ECM EIF NPM .55 .GJ 29N AAQXK AAYXX ABTAH ADIYS ADMUD AFJKZ AHHHB ASPBG AVWKF AZFZN CITATION FEDTE FGOYB G-2 HMQ HVGLF HZ~ MVM R2- SEW SNS WUQ X7M ZGI ZXP ZY4
ID	FETCH-LOGICAL-c474t-8e7cc6f2adb84149d036fcf25a032ef58e29c2b3f61a61b1cffc5f64cee98d573
IEDL.DBID	.~1
ISSN	0304-3940
IngestDate	Thu Sep 26 16:58:19 EDT 2024 Sat Sep 28 07:59:17 EDT 2024 Fri Feb 23 02:24:19 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	Reactive astrogliosis NO Neuroprotection TNFα JNK ALS CNS Iba1 COX-1/2 LPS GLAST PI3K EAAT1/2 NMDA EAAC1 Brain homeostasis Neurotrophins GSH vGLUT1 AD BDNF MS MMPs STAT3 EAE PLCγ MAPK NGF IP3 i.t GFAP vGAT PD Ca2 Systems biology GlyT-1 GABA SCI HD ATP BB14 GLT-1
Language	English
License	http://creativecommons.org/licenses/by-nc-nd/3.0 Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c474t-8e7cc6f2adb84149d036fcf25a032ef58e29c2b3f61a61b1cffc5f64cee98d573
OpenAccessLink	https://www.sciencedirect.com/science/article/pii/S030439401400041X
PMID	24457173
PageCount	6
ParticipantIDs	crossref_primary_10_1016_j_neulet_2014_01_014 pubmed_primary_24457173 elsevier_sciencedirect_doi_10_1016_j_neulet_2014_01_014
PublicationCentury	2000
PublicationDate	2014-04-17
PublicationDateYYYYMMDD	2014-04-17
PublicationDate_xml	– month: 04 year: 2014 text: 2014-04-17 day: 17
PublicationDecade	2010
PublicationPlace	Ireland
PublicationPlace_xml	– name: Ireland
PublicationTitle	Neuroscience letters
PublicationTitleAlternate	Neurosci Lett
PublicationYear	2014
Publisher	Elsevier Ireland Ltd
Publisher_xml	– name: Elsevier Ireland Ltd
References	Parpura, Heneka, Montana, Oliet, Schousboe, Haydon, Stout, Spray, Reichenbach, Pannicke, Pekny, Pekna, Zorec, Verkhratsky (bib0175) 2012; 121 Cirillo, Bianco, Colangelo, Cavaliere, de Daniele, Zaccaro, Alberghina, Papa (bib0060) 2011; 41 Cragnolini, Huang, Gokina, Friedman (bib0085) 2009; 57 Alberghina, Gaglio, Moresco, Gilardi, Messa, Vanoni (bib0015) 2013; June Crespo, Roomp, Jurkowski, Kitano, del Sol (bib0090) 2012; 6 Giralt, Friedman, Caneda-Ferrón, Urbán, Moreno, Rubio, Blanco, Peterson, Canals, Alberch (bib0115) 2010; 17 Colangelo, Cirillo, Lavitrano, Alberghina, Papa (bib0075) 2012; 30 Domeniconi, Hempstead, Chao (bib0100) 2007; 34 Rothstein, Patel, Regan, Haenggeli, Huang, Bergles, Jin, Dykes Hoberg, Vidensky, Chung, Toan, Bruijn, Su, Gupta, Fisher (bib0195) 2005; 433 Sofroniew, Vinters (bib0200) 2010; 119 Mayer (bib0145) 2011; 12 Chen, O’Reilly, Schwarzschild, Ascherio (bib0050) 2008; 167 Magistretti (bib0135) 2006; 209 Okada, Nakamura, Katoh, Miyao, Shimazaki, Ishii, Yamane, Yoshimura, Iwamoto, Toyama, Okano (bib0170) 2006; 12 Bae, Kim, Lee, Wee, Yoo, Ock Oh, Baek, Kim, Kim, Sik-Yoon, Bae (bib0020) 2006; 1763 Ni, Parpura (bib0165) 2009; 57 Rothstein, Dykes-Hoberg, Pardo, Bristol, Jin, Kuncl, Kanai, Hediger, Wang, Schielke, Welty (bib0190) 1996; 16 Bruno, Clarke, Seltzer, Quirion, Burgess, Cuello, Saragovi (bib0040) 2004; 24 Verkhratsky, Rodríguez, Steardo (bib0210) 2013; December Cirillo, Colangelo, Bianco, Cavaliere, Zaccaro, Sarmientos, Alberghina, Papa (bib0065) 2012; 30 Carbone, Duty, Rattray (bib0045) 2012; 60 Cirillo, Cavaliere, Bianco, De Simone, Colangelo, Sellitti, Alberghina, Papa (bib0055) 2010; 30 Côté, Carmichael, Verreault, Lindsay, Lefebvre, Laurin (bib0080) 2012; 8 Mizuta, Ohta, Ohta, Nishimura, Mizuta, Kuno (bib0160) 2001; 310 Bianco, Berbenni, Amara, Viggiani, Fragni, Galimberti, Colombo, Cirillo, Papa, Alberghina, Colangelo (bib0025) 2011; 89 Marcello, Cavaliere, Colangelo, Bianco, Cirillo, Alberghina, Papa (bib0140) 2013; 17 Mizuno, Iijima, Ogishima, Kikuchi, Matsuoka, Ghosh, Miyamoto, Miyashita, Kuwano, Tanaka (bib0155) 2012; 6 Cuello, Bruno (bib0095) 2007; 32 Alberghina, Colangelo (bib0010) 2006; 7 Brambilla, Persaud, Hu, Karmally, Shestopalov, Dvoriantchikova, Ivanov, Nathanson, Barnum, Bethea (bib0030) 2009; 182 Rothstein, Martin, Kuncl (bib0185) 1992; 326 Glass, Saijo, Winner, Marchetto, Gage (bib0120) 2010; 140 Lewerenz, Klein, Methner (bib0130) 2006; 98 Branger, van den Blink, Weijer, Madwed, Bos, Gupta, Yong, Polmar, Olszyna, Hack, van Deventer, Peppelenbosch, van der Poll (bib0035) 2002; 168 Agulhon, Sun, Murphy, Myers, Lauderdale, Fiacco (bib0005) 2012; 3 Colangelo, Bianco, Vitagliano, Cavaliere, Cirillo, De Gioia, Diana, Colombo, Redaelli, Zaccaro, Morelli, Papa, Sarmientos, Alberghina, Martegani (bib0070) 2008; 28 Franke, Verkhratsky, Burnstock, Illes (bib0105) 2012; 8 Fujita, Ostaszewski, Matsuoka, Ghosh, Glaab, Trefois, Crespo, Perumal, Jurkowski, Antony, Diederich, Buttini, Kodama, Satagopam, Eifes, Del Sol, Schneider, Kitano, Balling (bib0110) 2013; July Miller, Mitchell, Moore (bib0150) 2012; 3 Zaccaro, Lee, Pattarawarapan, Xia, Caron, L’Heureux, Bengio, Burgess, Saragovi (bib0215) 2005; 12 Lepore, Rauck, Dejea, Pardo, Rao, Rothstein, Maragakis (bib0125) 2008; 11 Squitieri, Orobello, Cannella, Martino, Romanelli, Giovacchini, Frati, Mansi, Ciarmiello (bib0205) 2009; 36 Piao, Kim, Han, Lee (bib0180) 2003; 73 Fujita (10.1016/j.neulet.2014.01.014_bib0110) 2013; July Zaccaro (10.1016/j.neulet.2014.01.014_bib0215) 2005; 12 Carbone (10.1016/j.neulet.2014.01.014_bib0045) 2012; 60 Bianco (10.1016/j.neulet.2014.01.014_bib0025) 2011; 89 Cuello (10.1016/j.neulet.2014.01.014_bib0095) 2007; 32 Miller (10.1016/j.neulet.2014.01.014_bib0150) 2012; 3 Alberghina (10.1016/j.neulet.2014.01.014_bib0010) 2006; 7 Giralt (10.1016/j.neulet.2014.01.014_bib0115) 2010; 17 Rothstein (10.1016/j.neulet.2014.01.014_bib0190) 1996; 16 Verkhratsky (10.1016/j.neulet.2014.01.014_bib0210) 2013; December Cirillo (10.1016/j.neulet.2014.01.014_bib0060) 2011; 41 Cragnolini (10.1016/j.neulet.2014.01.014_bib0085) 2009; 57 Franke (10.1016/j.neulet.2014.01.014_bib0105) 2012; 8 Okada (10.1016/j.neulet.2014.01.014_bib0170) 2006; 12 Branger (10.1016/j.neulet.2014.01.014_bib0035) 2002; 168 Alberghina (10.1016/j.neulet.2014.01.014_bib0015) 2013; June Marcello (10.1016/j.neulet.2014.01.014_bib0140) 2013; 17 Mizuta (10.1016/j.neulet.2014.01.014_bib0160) 2001; 310 Côté (10.1016/j.neulet.2014.01.014_bib0080) 2012; 8 Colangelo (10.1016/j.neulet.2014.01.014_bib0070) 2008; 28 Mayer (10.1016/j.neulet.2014.01.014_bib0145) 2011; 12 Brambilla (10.1016/j.neulet.2014.01.014_bib0030) 2009; 182 Crespo (10.1016/j.neulet.2014.01.014_bib0090) 2012; 6 Cirillo (10.1016/j.neulet.2014.01.014_bib0065) 2012; 30 Lewerenz (10.1016/j.neulet.2014.01.014_bib0130) 2006; 98 Colangelo (10.1016/j.neulet.2014.01.014_bib0075) 2012; 30 Bae (10.1016/j.neulet.2014.01.014_bib0020) 2006; 1763 Cirillo (10.1016/j.neulet.2014.01.014_bib0055) 2010; 30 Domeniconi (10.1016/j.neulet.2014.01.014_bib0100) 2007; 34 Lepore (10.1016/j.neulet.2014.01.014_bib0125) 2008; 11 Rothstein (10.1016/j.neulet.2014.01.014_bib0185) 1992; 326 Sofroniew (10.1016/j.neulet.2014.01.014_bib0200) 2010; 119 Chen (10.1016/j.neulet.2014.01.014_bib0050) 2008; 167 Magistretti (10.1016/j.neulet.2014.01.014_bib0135) 2006; 209 Parpura (10.1016/j.neulet.2014.01.014_bib0175) 2012; 121 Agulhon (10.1016/j.neulet.2014.01.014_bib0005) 2012; 3 Rothstein (10.1016/j.neulet.2014.01.014_bib0195) 2005; 433 Ni (10.1016/j.neulet.2014.01.014_bib0165) 2009; 57 Piao (10.1016/j.neulet.2014.01.014_bib0180) 2003; 73 Squitieri (10.1016/j.neulet.2014.01.014_bib0205) 2009; 36 Bruno (10.1016/j.neulet.2014.01.014_bib0040) 2004; 24 Mizuno (10.1016/j.neulet.2014.01.014_bib0155) 2012; 6 Glass (10.1016/j.neulet.2014.01.014_bib0120) 2010; 140
References_xml	– volume: 433 start-page: 73 year: 2005 end-page: 77 ident: bib0195 article-title: Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression publication-title: Nature contributor: fullname: Fisher – volume: 60 start-page: 31 year: 2012 end-page: 38 ident: bib0045 article-title: Riluzole elevates GLT-1 activity and levels in striatal astrocytes publication-title: Neurochem. Int. contributor: fullname: Rattray – volume: 30 start-page: 261 year: 2012 end-page: 271 ident: bib0075 article-title: Targeting reactive astrogliosis by novel biotechnological strategies publication-title: Biotechnol. Adv. contributor: fullname: Papa – volume: June year: 2013 ident: bib0015 article-title: A systems biology road map for the discovery of drugs targeting cancer cell metabolism publication-title: Curr. Pharm. Des. contributor: fullname: Vanoni – volume: 11 start-page: 1294 year: 2008 end-page: 1301 ident: bib0125 article-title: Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease publication-title: Nat. Neurosci. contributor: fullname: Maragakis – volume: 326 start-page: 1464 year: 1992 end-page: 1468 ident: bib0185 article-title: Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis publication-title: N. Engl. J. Med. contributor: fullname: Kuncl – volume: 167 start-page: 90 year: 2008 end-page: 95 ident: bib0050 article-title: Peripheral inflammatory biomarkers and risk of Parkinson's disease publication-title: Am. J. Epidemiol. contributor: fullname: Ascherio – volume: 6 start-page: 132 year: 2012 ident: bib0090 article-title: Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease publication-title: BMC Syst. Biol. contributor: fullname: del Sol – volume: 17 start-page: 799 year: 2013 end-page: 810 ident: bib0140 article-title: Remodelling of supraspinal neuroglial network in neuropathic pain is featured by a reactive gliosis of the nociceptive amygdala publication-title: Eur. J. Pain. contributor: fullname: Papa – volume: 73 start-page: 537 year: 2003 end-page: 544 ident: bib0180 article-title: Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult publication-title: J. Neurosci. Res. contributor: fullname: Lee – volume: 57 start-page: 1296 year: 2009 end-page: 1305 ident: bib0165 article-title: Dual regulation of Ca publication-title: Glia contributor: fullname: Parpura – volume: 6 start-page: 52 year: 2012 ident: bib0155 article-title: AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease publication-title: BMC Syst. Biol. contributor: fullname: Tanaka – volume: 8 start-page: 629 year: 2012 end-page: 657 ident: bib0105 article-title: Pathophysiology of astroglial purinergic signalling publication-title: Purinergic Signal. contributor: fullname: Illes – volume: 16 start-page: 675 year: 1996 end-page: 686 ident: bib0190 article-title: Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate publication-title: Neuron contributor: fullname: Welty – volume: 3 start-page: 139 year: 2012 ident: bib0005 article-title: Calcium signaling and gliotransmission in normal vs. reactive astrocytes publication-title: Front. Pharmacol. contributor: fullname: Fiacco – volume: December year: 2013 ident: bib0210 article-title: Astrogliopathology: a central element of neuropsychiatric diseases? publication-title: Neuroscientist contributor: fullname: Steardo – volume: 3 start-page: CD001447 year: 2012 ident: bib0150 article-title: Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) publication-title: Cochrane Database Syst. Rev. contributor: fullname: Moore – volume: 89 start-page: 1302 year: 2011 end-page: 1315 ident: bib0025 article-title: Cross-talk between cell cycle induction and mitochondrial dysfunction during oxidative stress and nerve growth factor withdrawal in differentiated PC12 cells publication-title: J. Neurosci. Res. contributor: fullname: Colangelo – volume: 57 start-page: 1386 year: 2009 end-page: 1392 ident: bib0085 article-title: Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor publication-title: Glia contributor: fullname: Friedman – volume: 17 start-page: 1294 year: 2010 end-page: 1308 ident: bib0115 article-title: BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease publication-title: Gene Ther. contributor: fullname: Alberch – volume: 12 start-page: 453 year: 2011 end-page: 466 ident: bib0145 article-title: Gut feelings: the emerging biology of gut-brain communication publication-title: Nat. Rev. Neurosci. contributor: fullname: Mayer – volume: 12 start-page: 1015 year: 2005 end-page: 1028 ident: bib0215 article-title: Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities publication-title: Chem. Biol. contributor: fullname: Saragovi – volume: 28 start-page: 2698 year: 2008 end-page: 2709 ident: bib0070 article-title: A new nerve growth factor-mimetic peptide active on neuropathic pain in rats publication-title: J. Neurosci. contributor: fullname: Martegani – volume: 1763 start-page: 282 year: 2006 end-page: 289 ident: bib0020 article-title: Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells publication-title: Biochim. Biophys. Acta contributor: fullname: Bae – volume: 209 start-page: 2304 year: 2006 end-page: 2311 ident: bib0135 article-title: Neuron-glia metabolic coupling and plasticity publication-title: J. Exp. Biol. contributor: fullname: Magistretti – volume: 168 start-page: 4070 year: 2002 end-page: 4077 ident: bib0035 article-title: Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia publication-title: J. Immunol. contributor: fullname: van der Poll – volume: 121 start-page: 4 year: 2012 end-page: 27 ident: bib0175 article-title: Glial cells in (patho)physiology publication-title: J. Neurochem. contributor: fullname: Verkhratsky – volume: 8 start-page: 219 year: 2012 end-page: 226 ident: bib0080 article-title: Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease publication-title: Alzheimers Dement. contributor: fullname: Laurin – volume: 310 start-page: 117 year: 2001 end-page: 120 ident: bib0160 article-title: Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes publication-title: Neurosci. Lett. contributor: fullname: Kuno – volume: 182 start-page: 2628 year: 2009 end-page: 2640 ident: bib0030 article-title: Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation publication-title: J. Immunol. contributor: fullname: Bethea – volume: 34 start-page: 271 year: 2007 end-page: 279 ident: bib0100 article-title: Pro-NGF secreted by astrocytes promotes motor neuron cell death publication-title: Mol. Cell. Neurosci. contributor: fullname: Chao – volume: 30 start-page: 51 year: 2010 end-page: 62 ident: bib0055 article-title: Intrathecal NGF administration reduces reactive astrocytosis and changes neurotrophin receptors expression pattern in a rat model of neuropathic pain publication-title: Cell. Mol. Neurobiol. contributor: fullname: Papa – volume: 30 start-page: 223 year: 2012 end-page: 232 ident: bib0065 article-title: BB14, a nerve growth factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury publication-title: Biotechnol. Adv. contributor: fullname: Papa – volume: 119 start-page: 7 year: 2010 end-page: 35 ident: bib0200 article-title: Astrocytes: biology and pathology publication-title: Acta Neuropathol. contributor: fullname: Vinters – volume: 12 start-page: 829 year: 2006 end-page: 834 ident: bib0170 article-title: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury publication-title: Nat. Med. contributor: fullname: Okano – volume: 36 start-page: 1113 year: 2009 end-page: 1120 ident: bib0205 article-title: Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins publication-title: Eur. J. Nucl. Med. Mol. Imaging contributor: fullname: Ciarmiello – volume: 7 start-page: S2 year: 2006 ident: bib0010 article-title: The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration publication-title: BMC Neurosci. contributor: fullname: Colangelo – volume: July year: 2013 ident: bib0110 article-title: Integrating pathways of Parkinson's disease in a molecular interaction map publication-title: Mol. Neurobiol. contributor: fullname: Balling – volume: 98 start-page: 916 year: 2006 end-page: 925 ident: bib0130 article-title: Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc-protects from oxidative glutamate toxicity publication-title: J. Neurochem. contributor: fullname: Methner – volume: 24 start-page: 8009 year: 2004 end-page: 8018 ident: bib0040 article-title: Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA publication-title: J. Neurosci. contributor: fullname: Saragovi – volume: 41 start-page: 630 year: 2011 end-page: 639 ident: bib0060 article-title: Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor publication-title: Neurobiol. Dis. contributor: fullname: Papa – volume: 140 start-page: 918 year: 2010 end-page: 934 ident: bib0120 article-title: Mechanisms underlying inflammation in neurodegeneration publication-title: Cell contributor: fullname: Gage – volume: 32 start-page: 1041 year: 2007 end-page: 1045 ident: bib0095 article-title: The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease publication-title: Neurochem. Res. contributor: fullname: Bruno – volume: 34 start-page: 271 year: 2007 ident: 10.1016/j.neulet.2014.01.014_bib0100 article-title: Pro-NGF secreted by astrocytes promotes motor neuron cell death publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2006.11.005 contributor: fullname: Domeniconi – volume: 6 start-page: 52 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0155 article-title: AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease publication-title: BMC Syst. Biol. doi: 10.1186/1752-0509-6-52 contributor: fullname: Mizuno – volume: 8 start-page: 219 issue: 3 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0080 article-title: Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.012 contributor: fullname: Côté – volume: 12 start-page: 453 issue: 8 year: 2011 ident: 10.1016/j.neulet.2014.01.014_bib0145 article-title: Gut feelings: the emerging biology of gut-brain communication publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3071 contributor: fullname: Mayer – volume: 98 start-page: 916 year: 2006 ident: 10.1016/j.neulet.2014.01.014_bib0130 article-title: Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc-protects from oxidative glutamate toxicity publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2006.03921.x contributor: fullname: Lewerenz – volume: 89 start-page: 1302 issue: 8 year: 2011 ident: 10.1016/j.neulet.2014.01.014_bib0025 article-title: Cross-talk between cell cycle induction and mitochondrial dysfunction during oxidative stress and nerve growth factor withdrawal in differentiated PC12 cells publication-title: J. Neurosci. Res. doi: 10.1002/jnr.22665 contributor: fullname: Bianco – volume: 8 start-page: 629 issue: 3 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0105 article-title: Pathophysiology of astroglial purinergic signalling publication-title: Purinergic Signal. doi: 10.1007/s11302-012-9300-0 contributor: fullname: Franke – volume: 209 start-page: 2304 year: 2006 ident: 10.1016/j.neulet.2014.01.014_bib0135 article-title: Neuron-glia metabolic coupling and plasticity publication-title: J. Exp. Biol. doi: 10.1242/jeb.02208 contributor: fullname: Magistretti – volume: 57 start-page: 1296 year: 2009 ident: 10.1016/j.neulet.2014.01.014_bib0165 article-title: Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels publication-title: Glia doi: 10.1002/glia.20849 contributor: fullname: Ni – volume: 12 start-page: 829 issue: 7 year: 2006 ident: 10.1016/j.neulet.2014.01.014_bib0170 article-title: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury publication-title: Nat. Med. doi: 10.1038/nm1425 contributor: fullname: Okada – volume: 17 start-page: 799 year: 2013 ident: 10.1016/j.neulet.2014.01.014_bib0140 article-title: Remodelling of supraspinal neuroglial network in neuropathic pain is featured by a reactive gliosis of the nociceptive amygdala publication-title: Eur. J. Pain. doi: 10.1002/j.1532-2149.2012.00255.x contributor: fullname: Marcello – volume: 121 start-page: 4 issue: 1 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0175 article-title: Glial cells in (patho)physiology publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2012.07664.x contributor: fullname: Parpura – volume: 168 start-page: 4070 issue: 8 year: 2002 ident: 10.1016/j.neulet.2014.01.014_bib0035 article-title: Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia publication-title: J. Immunol. doi: 10.4049/jimmunol.168.8.4070 contributor: fullname: Branger – volume: 16 start-page: 675 year: 1996 ident: 10.1016/j.neulet.2014.01.014_bib0190 article-title: Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate publication-title: Neuron doi: 10.1016/S0896-6273(00)80086-0 contributor: fullname: Rothstein – volume: 24 start-page: 8009 year: 2004 ident: 10.1016/j.neulet.2014.01.014_bib0040 article-title: Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1508-04.2004 contributor: fullname: Bruno – volume: June year: 2013 ident: 10.1016/j.neulet.2014.01.014_bib0015 article-title: A systems biology road map for the discovery of drugs targeting cancer cell metabolism publication-title: Curr. Pharm. Des. contributor: fullname: Alberghina – volume: 41 start-page: 630 year: 2011 ident: 10.1016/j.neulet.2014.01.014_bib0060 article-title: Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2010.11.012 contributor: fullname: Cirillo – volume: 167 start-page: 90 issue: 1 year: 2008 ident: 10.1016/j.neulet.2014.01.014_bib0050 article-title: Peripheral inflammatory biomarkers and risk of Parkinson's disease publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwm260 contributor: fullname: Chen – volume: 140 start-page: 918 year: 2010 ident: 10.1016/j.neulet.2014.01.014_bib0120 article-title: Mechanisms underlying inflammation in neurodegeneration publication-title: Cell doi: 10.1016/j.cell.2010.02.016 contributor: fullname: Glass – volume: 30 start-page: 223 issue: 1 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0065 article-title: BB14, a nerve growth factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2011.05.008 contributor: fullname: Cirillo – volume: 326 start-page: 1464 issue: 22 year: 1992 ident: 10.1016/j.neulet.2014.01.014_bib0185 article-title: Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199205283262204 contributor: fullname: Rothstein – volume: 32 start-page: 1041 year: 2007 ident: 10.1016/j.neulet.2014.01.014_bib0095 article-title: The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease publication-title: Neurochem. Res. doi: 10.1007/s11064-006-9270-0 contributor: fullname: Cuello – volume: 7 start-page: S2 issue: October (Suppl. 1) year: 2006 ident: 10.1016/j.neulet.2014.01.014_bib0010 article-title: The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration publication-title: BMC Neurosci. doi: 10.1186/1471-2202-7-S1-S2 contributor: fullname: Alberghina – volume: 57 start-page: 1386 year: 2009 ident: 10.1016/j.neulet.2014.01.014_bib0085 article-title: Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor publication-title: Glia doi: 10.1002/glia.20857 contributor: fullname: Cragnolini – volume: 73 start-page: 537 issue: 4 year: 2003 ident: 10.1016/j.neulet.2014.01.014_bib0180 article-title: Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult publication-title: J. Neurosci. Res. doi: 10.1002/jnr.10671 contributor: fullname: Piao – volume: 119 start-page: 7 issue: 1 year: 2010 ident: 10.1016/j.neulet.2014.01.014_bib0200 article-title: Astrocytes: biology and pathology publication-title: Acta Neuropathol. doi: 10.1007/s00401-009-0619-8 contributor: fullname: Sofroniew – volume: 1763 start-page: 282 issue: 3 year: 2006 ident: 10.1016/j.neulet.2014.01.014_bib0020 article-title: Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2006.01.005 contributor: fullname: Bae – volume: 60 start-page: 31 issue: 1 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0045 article-title: Riluzole elevates GLT-1 activity and levels in striatal astrocytes publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2011.10.017 contributor: fullname: Carbone – volume: July year: 2013 ident: 10.1016/j.neulet.2014.01.014_bib0110 article-title: Integrating pathways of Parkinson's disease in a molecular interaction map publication-title: Mol. Neurobiol. contributor: fullname: Fujita – volume: 6 start-page: 132 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0090 article-title: Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease publication-title: BMC Syst. Biol. doi: 10.1186/1752-0509-6-132 contributor: fullname: Crespo – volume: 182 start-page: 2628 issue: 5 year: 2009 ident: 10.1016/j.neulet.2014.01.014_bib0030 article-title: Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation publication-title: J. Immunol. doi: 10.4049/jimmunol.0802954 contributor: fullname: Brambilla – volume: 310 start-page: 117 issue: 2–3 year: 2001 ident: 10.1016/j.neulet.2014.01.014_bib0160 article-title: Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(01)02098-5 contributor: fullname: Mizuta – volume: 28 start-page: 2698 year: 2008 ident: 10.1016/j.neulet.2014.01.014_bib0070 article-title: A new nerve growth factor-mimetic peptide active on neuropathic pain in rats publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5201-07.2008 contributor: fullname: Colangelo – volume: 17 start-page: 1294 issue: 10 year: 2010 ident: 10.1016/j.neulet.2014.01.014_bib0115 article-title: BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease publication-title: Gene Ther. doi: 10.1038/gt.2010.71 contributor: fullname: Giralt – volume: 12 start-page: 1015 year: 2005 ident: 10.1016/j.neulet.2014.01.014_bib0215 article-title: Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2005.06.015 contributor: fullname: Zaccaro – volume: 30 start-page: 51 year: 2010 ident: 10.1016/j.neulet.2014.01.014_bib0055 article-title: Intrathecal NGF administration reduces reactive astrocytosis and changes neurotrophin receptors expression pattern in a rat model of neuropathic pain publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-009-9430-2 contributor: fullname: Cirillo – volume: 30 start-page: 261 issue: 1 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0075 article-title: Targeting reactive astrogliosis by novel biotechnological strategies publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2011.06.016 contributor: fullname: Colangelo – volume: 433 start-page: 73 issue: 7021 year: 2005 ident: 10.1016/j.neulet.2014.01.014_bib0195 article-title: Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression publication-title: Nature doi: 10.1038/nature03180 contributor: fullname: Rothstein – volume: 3 start-page: CD001447 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0150 article-title: Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) publication-title: Cochrane Database Syst. Rev. contributor: fullname: Miller – volume: 36 start-page: 1113 issue: 7 year: 2009 ident: 10.1016/j.neulet.2014.01.014_bib0205 article-title: Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-009-1103-3 contributor: fullname: Squitieri – volume: 3 start-page: 139 year: 2012 ident: 10.1016/j.neulet.2014.01.014_bib0005 article-title: Calcium signaling and gliotransmission in normal vs. reactive astrocytes publication-title: Front. Pharmacol. doi: 10.3389/fphar.2012.00139 contributor: fullname: Agulhon – volume: 11 start-page: 1294 issue: 11 year: 2008 ident: 10.1016/j.neulet.2014.01.014_bib0125 article-title: Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease publication-title: Nat. Neurosci. doi: 10.1038/nn.2210 contributor: fullname: Lepore – volume: December year: 2013 ident: 10.1016/j.neulet.2014.01.014_bib0210 article-title: Astrogliopathology: a central element of neuropsychiatric diseases? publication-title: Neuroscientist contributor: fullname: Verkhratsky
SSID	ssj0005154
Score	2.524508
SecondaryResourceType	review_article
Snippet	•We briefly review the role of astrocytes in brain function.•We review the main pathways in astrocytic dysfunction.•We focus on astroglial-specific targets for... Chronic neurodegenerative diseases represent major unmet needs for therapeutic interventions. Recently, the neurocentric view of brain function and disease has...
SourceID	crossref pubmed elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	59
SubjectTerms	Animals Astrocytes - pathology Astrocytes - transplantation Brain - drug effects Brain - pathology Brain homeostasis Drug Discovery Gliosis - pathology Gliosis - therapy Glutamic Acid - metabolism Humans Inflammation - drug therapy Inflammation - pathology Nerve Growth Factors - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotrophins Reactive astrogliosis Signal Transduction Synapses - physiology Systems Biology
Title	Astrogliosis as a therapeutic target for neurodegenerative diseases
URI	https://dx.doi.org/10.1016/j.neulet.2014.01.014 https://www.ncbi.nlm.nih.gov/pubmed/24457173
Volume	565
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEF5KBfEi2vqoj7IH8RabTTbZ5BiKpSrtRQu9hWSzWyKaljY9ePG3O7NJpJ4Kwl4S8uLLZh6Zb74l5C7jNkqmJDh5tcXDRFihLeG7cvwA5dCVNuunTKb-eMaf5968RYZNLwzSKmvbX9l0Y63rPYMazcEqzwevWNTDdb0hRUDVqDl2sIP7gzn98L1D82BeJSGFFQA4ummfMxyvQm0BHSR4cSPeyfge97Tje0Yn5LgOGmlUPdcpaamiQ7pRAQnz5xe9p4bGaf6Pd8jhpK6Wd8kw2pTr5eIjX27yDU1g0J12K1qRwClErdSoWmZqYTSo0QDSunCzOSOz0ePbcGzViyZYkgteWoESUvraSbI04JD-ZOCitNSOl9iuo7QXKCeUTupqnyU-S5nUWnra5-AswyDzhHtO2sWyUJeEhiLFMp3gqci4sNMkwS7aTMqAKeVq0SNWg1W8qrQx4oY09h5X2MaIbWwzGLxHRANo_Ocdx2C-95x5UeH_ex-ISjwkEFz9-5rX5Ai3sDLExA1pl-utuoUAo0z7Zgb1yUH09DKe_gCX_M-p
link.rule.ids	315,783,787,4509,24128,27936,27937,45597,45691
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JT8JAFH5BTNSLUXDBdQ7GW6XLtNMeCZGgAhch4da00xlSo4XQcvDib3fetDV4MjGZU_d8nb6l73vfANwl1ETJlAgnrzRoEDEjMLn6rmzPRzl0IfX6KeOJN5zR57k7b0C_7oVBWmVl-0ubrq11taVbodldpWn3FYt6uK63ShFQNWq-A7sU42M1qR--tngelltqSGEJQB1e989pklcmNgoeZHhRrd5p0T_805bzGRzBYRU1kl75YMfQEFkL2r1MZcwfn-SeaB6n_kHegr1xVS5vQ7-XF-vl4j1d5mlOIjXIVr8VKVngRIWtRMtaJmKhRajRApKqcpOfwGzwOO0PjWrVBINTRgvDF4xzT9pREvtU5T-J8lGSS9uNTMcW0vWFHXA7dqRnRZ4VW1xK7kqPKm8Z-InLnFNoZstMnAMJWIx1OkZjllBmxlGEbbQJ574lhCNZB4waq3BVimOENWvsLSyxDRHb0LTUoB1gNaDhr5ccKvv9x5lnJf4_91FhiYsMgot_X_MW9ofT8SgcPU1eLuEA92CZyGJX0CzWG3Gtoo0ivtGz6RudkNFC
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Astrogliosis+as+a+therapeutic+target+for+neurodegenerative+diseases&rft.jtitle=Neuroscience+letters&rft.au=Colangelo%2C+Anna+Maria&rft.au=Alberghina%2C+Lilia&rft.au=Papa%2C+Michele&rft.date=2014-04-17&rft.issn=0304-3940&rft.volume=565&rft.spage=59&rft.epage=64&rft_id=info:doi/10.1016%2Fj.neulet.2014.01.014&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_neulet_2014_01_014
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3940&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3940&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3940&client=summon