Immune correlates of postexposure vaccine protection against Marburg virus

• Published in: Scientific reports Vol. 10; no. 1; p. 3071
• Main Authors: Woolsey, Courtney, Jankeel, Allen, Matassov, Demetrius, Geisbert, Joan B., Agans, Krystle N., Borisevich, Viktoriya, Cross, Robert W., Deer, Daniel J., Fenton, Karla A., Latham, Theresa E., Gerardi, Cheryl S., Mire, Chad E., Eldridge, John H., Messaoudi, Ilhem, Geisbert, Thomas W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.02.2020; Nature Publishing Group
• Subjects: 13/31; 38/91; 631/326/590/1867; 631/326/596/2041; Animals; Antibodies, Viral - biosynthesis; Antibodies, Viral - immunology; Antiviral drugs; Cytokines - blood; Cytotoxicity, Immunologic; Disease transmission; Dose-Response Relationship, Immunologic; Down-Regulation - genetics; Female; Filoviridae; Gene mapping; Histocompatibility antigen HLA; Humanities and Social Sciences; Immune checkpoint; Immunization; Immunoregulation; Immunostimulation; Infectious diseases; Inflammation - blood; Inflammation - immunology; Interferon; Interferons - genetics; Interferons - metabolism; Killer Cells, Natural - immunology; Lymphocytes T; Macaca mulatta - immunology; Macaca mulatta - virology; Male; Marburg disease; Marburg Virus Disease - blood; Marburg Virus Disease - genetics; Marburg Virus Disease - immunology; Marburg Virus Disease - virology; Marburgvirus - immunology; Medical prognosis; Monocytes; multidisciplinary; PD-1 protein; Peripheral blood; Post-Exposure Prophylaxis; Recombination, Genetic - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Stomatitis; T-Lymphocytes, Helper-Inducer - immunology; Th1 Cells - immunology; Th2 Cells - immunology; Transcription; Transcriptome - genetics; Up-Regulation - genetics; Vaccines; Vectors; Vesiculovirus - genetics; Viral Load - immunology; Viral Vaccines - immunology; Viruses

Postexposure immunization can prevent disease and reduce transmission following pathogen exposure. The rapid immunostimulatory properties of recombinant vesicular stomatitis virus (rVSV)-based vaccines make them suitable postexposure treatments against the filoviruses Ebola virus and Marburg virus (...