BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states

• Published in: Cell reports (Cambridge) Vol. 38; no. 9; p. 110438
• Main Authors: Beumer, Joep, Puschhof, Jens, Yengej, Fjodor Yousef, Zhao, Lianzheng, Martinez-Silgado, Adriana, Blotenburg, Marloes, Begthel, Harry, Boot, Charelle, van Oudenaarden, Alexander, Chen, Ye-Guang, Clevers, Hans
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022
• Subjects: Animals; BMP signaling; Bone Morphogenetic Proteins - metabolism; Cell Differentiation; CRISPR-Cas9; enterocytes; Enterocytes - metabolism; Goblet Cells; intestinal differentiation; Intestinal Mucosa - metabolism; Intestine, Small - metabolism; Mice; organoids; single-cell RNA sequencing; single-cell RNA sequencing; BMP signaling; intestinal differentiation; enterocytes; organoids; CRISPR-Cas9

Intestinal epithelial cells derive from stem cells at the crypt base and travel along the crypt-villus axis to die at the villus tip. The two dominant villus epithelial cell types, absorptive enterocytes and mucous-secreting goblet cells, are mature when they exit crypts. Murine enterocytes switch f...