A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53

• Published in: PloS one Vol. 13; no. 3; p. e0193485
• Main Authors: Dibra, Denada, Xia, Xueqing, Gagea, Mihai, Lozano, Guillermina, Li, Shulin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2018; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Medicine and Health Sciences; Research and Analysis Methods

Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model with which to study the biology of this disease and to develop therapeutics is lacking. One of the most accepted animal models for this dise...