Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria - Badri, Prajakta; Jiang, Xuemin; Borodovsky, Anna; Najafian, Nader; Kim, Jae; Clausen, Valerie A.; Goel, Varun; Habtemariam, Bahru; Robbie, Gabriel J. (Clinical pharmacokinetics, 2021)
Keywords: Antibodies; Complement C5 - pharmacokinetics; Gene expression; Healthy Volunteers; Hemoglobinuria, Paroxysmal - drug therapy; Humans; Internal Medicine; Liver; Medicine; Medicine & Public Health; Monoclonal antibodies; NCT; NCT02352493; Original; Original Research Article; Pharmacodynamics; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Proteins; RNA Interference; RNAi Therapeutics