Aging and white matter microstructure and macrostructure: a longitudinal multi-site diffusion MRI study of 1218 participants

• Published in: Brain Structure and Function Vol. 227; no. 6; pp. 2111 - 2125
• Main Authors: Schilling, Kurt G., Archer, Derek, Yeh, Fang-Cheng, Rheault, Francois, Cai, Leon Y., Hansen, Colin, Yang, Qi, Ramdass, Karthik, Shafer, Andrea T., Resnick, Susan M., Pechman, Kimberly R., Gifford, Katherine A., Hohman, Timothy J., Jefferson, Angela, Anderson, Adam W., Kang, Hakmook, Landman, Bennett A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2022; Springer Nature B.V
• Subjects: Age; Aging; Biomedical and Life Sciences; Biomedicine; Brain - diagnostic imaging; Cell Biology; Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging - methods; Diffusion Tensor Imaging - methods; Humans; Longitudinal Studies; Magnetic resonance imaging; Nervous system; Neuroimaging; Neurology; Neurosciences; Original Article; Substantia alba; Thalamus; White Matter - diagnostic imaging; Aging; Diffusion MRI; Volume; White matter; Tractography

Quantifying the microstructural and macrostructural geometrical features of the human brain’s connections is necessary for understanding normal aging and disease. Here, we examine brain white matter diffusion magnetic resonance imaging data from one cross-sectional and two longitudinal data sets tot...