Depressive hypertension: A proposed human endotype of brain/gut microbiome dysbiosis

• Published in: The American heart journal Vol. 239; pp. 27 - 37
• Main Authors: Stevens, Bruce R., Pepine, Carl J., Richards, Elaine M., Kim, Seungbum, Raizada, Mohan K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021; Elsevier Limited
• Subjects: Amino acids; Biomarkers; Blood pressure; Brain; Brain research; Cardiology; Cardiovascular diseases; Clustering; Comorbidity; Confidence intervals; Crosstalk; Datasets; Depression; Digestive system; Discriminant analysis; DNA sequencing; Dysbacteriosis; Ecology; Fatty acids; Feature selection; Gastroenterology; Gastrointestinal system; Gastrointestinal tract; Genomics; Gut microbiota; Gut-brain axis; Heart diseases; High blood pressure; Hypertension; Inflammasomes; Intestinal microflora; Learning algorithms; Machine learning; Mental depression; Mental disorders; Metabolism; Metadata; Metagenomics; Microbiome; Microbiomes; Microbiota; Microorganisms; Mood; Multivariate analysis; Pathophysiology; Physiology; Principal components analysis; Psychiatry; Psychosis; Taxonomy; γ-Aminobutyric acid; PCoA; HTN; RAS; DEP-HTN; RAAS; PVN; ENS; BP; LPS; FDR; SNS; High blood pressure; fabZ; Hypertension; ACE; Pathophysiology; Depression; WMGS; SCFA; DEP; PCA; CVD; REF; GABA; HPA; dapE; lpxC; Microbiome; High Blood Pressure

Hypertension (HTN) is frequently linked with depression (DEP) in adults with cardiovascular disease (CVD), yet the underlying mechanism and successful management remain elusive. We approached this knowledge gap through the lens that humans are eukaryote-prokaryote "meta-organisms," such th...