SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice - Soares, Rogerio N.; Ramirez-Perez, Francisco I.; Cabral-Amador, Francisco J.; Morales-Quinones, Mariana; Foote, Christopher A.; Ghiarone, Thaysa; Sharma, Neekun; Power, Gavin; Smith, James A.; Rector, R. Scott; Martinez-Lemus, Luis A.; Padilla, Jaume; et al. (GeroScience, 2022)
Keywords: Actin; Actins - metabolism; Aged; Aging; Animals; Aorta; Atomic force microscopy; Biomedical and Life Sciences; Cardiovascular diseases; Cell Biology; Cofilin; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Geriatrics/Gerontology; Glucose transporter; Humans; Life Sciences; Male; Mice; Mice, Inbred C57BL; Molecular Medicine; Morbidity; Nitric oxide; Nitric-oxide synthase; Original; Original Article; Oxidative Stress; Pulse Wave Analysis; Reactive oxygen species; Sodium-glucose cotransporter; Sodium-Glucose Transporter 2 - metabolism; Sodium-Glucose Transporter 2 - therapeutic use; Sodium-Glucose Transporter 2 Inhibitors - pharmacology; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use; Vascular Diseases; Aging; Oxidative stress; Endothelial function; Arterial stiffness; SGLT2