β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model

• Published in: PloS one Vol. 16; no. 3; p. e0248150
• Main Authors: Takeda, Shogo, Terazawa, Shuko, Shimoda, Hiroshi, Imokawa, Genji
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.03.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Medicine and Health Sciences; Research and Analysis Methods

β-Sitosterol 3- O - d -glucoside (BSG) is known to act as an agonist by binding to estrogen receptors, and estrogen has been reported to enhance the activity of β-glucocerebrosidase, an epidermal ceramide metabolizing enzyme. In this study, we determined whether BSG up-regulates ceramide levels in t...