Change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction

Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist post-MI or if these measures differ between atherothrombotic versus non-atherothrombotic MI. MMPs-2, 3, and 9 were measured in 80 subjects wi...

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Published inJournal of thrombosis and thrombolysis Vol. 49; no. 2; pp. 235 - 244
Main Authors Owolabi, Ugochukwu Shola, Amraotkar, Alok Ravindra, Coulter, Amanda R., Singam, Narayana Sarma V., Aladili, Bahjat N., Singh, Ayesha, Trainor, Patrick James, Mitra, Riten, DeFilippis, Andrew Paul
Format Journal Article
LanguageEnglish
Published New York Springer US 01.02.2020
Springer Nature B.V
Subjects
Adult
Aged
Atherosclerosis - blood
Atherosclerosis - diagnostic imaging
Biomarkers - blood
Cardiology
Cardiovascular disease
Cohort Studies
Coronary artery
Electrocardiography
Female
Follow-Up Studies
Gelatinase A
Gelatinase B
Health risk assessment
Heart attacks
Heart diseases
Hematology
Humans
Male
Matrix metalloproteinase
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 3 - blood
Matrix Metalloproteinase 9 - blood
Medicine
Medicine & Public Health
Metalloproteinase
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnostic imaging
Prospective Studies
Stromelysin 1
Thrombosis - blood
Thrombosis - diagnostic imaging
Extracellular matrix
Atherothrombosis
Acute myocardial infarction
Metalloproteinases
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Abstract Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist post-MI or if these measures differ between atherothrombotic versus non-atherothrombotic MI. MMPs-2, 3, and 9 were measured in 80 subjects with acute MI (atherothrombotic and non-atherothrombotic MI) or stable coronary artery disease (CAD). Measurements were made at, the time of acute MI, and > 3-month following acute MI (quiescent phase). Outcome measures were compared between groups and between time of acute MI and quiescent post-MI follow-up using Wilcoxon’s and repeated measures analysis of variance. Forty-nine subjects met the criteria for acute MI with clearly defined atherothrombotic (n = 22) and non-atherothrombotic (n = 12) subsets. Fifteen subjects met criteria for stable CAD. MMP-3 was higher in acute MI versus stable CAD subjects at the time of acute MI: (453 vs. 217 pg/mL, p = 0.010) but not at quiescent phase follow-up (p > 0.05). MMP-9 was higher in acute MI versus stable CAD subjects at the time of acute MI: (412 vs. 168 pg/mL, p = 0.002) but not at the quiescent phase follow-up (p > 0.05). MMP-9 was higher at the time of acute MI versus quiescent phase follow-up in acute MI (412 vs. 213 pg/mL, p = 0.001) and atherothrombotic MI specifically (458 vs. 212 pg/mL, p = 0.001). No difference in MMP-2, 3, or 9 was observed between atherothrombotic versus non-atherothrombotic MI subgroups. MMPs-3 and 9 are significantly elevated in acute MI verses stable CAD subjects at time of acute MI but not different at quiescent phase follow-up. MMP-9 is elevated at the time of acute MI and specifically in acute atherothrombotic MI at time of MI versus quiescent phase follow-up.
AbstractList Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist post-MI or if these measures differ between atherothrombotic versus non-atherothrombotic MI. MMPs-2, 3, and 9 were measured in 80 subjects with acute MI (atherothrombotic and non-atherothrombotic MI) or stable coronary artery disease (CAD). Measurements were made at, the time of acute MI, and > 3-month following acute MI (quiescent phase). Outcome measures were compared between groups and between time of acute MI and quiescent post-MI follow-up using Wilcoxon’s and repeated measures analysis of variance. Forty-nine subjects met the criteria for acute MI with clearly defined atherothrombotic (n = 22) and non-atherothrombotic (n = 12) subsets. Fifteen subjects met criteria for stable CAD. MMP-3 was higher in acute MI versus stable CAD subjects at the time of acute MI: (453 vs. 217 pg/mL, p = 0.010) but not at quiescent phase follow-up (p > 0.05). MMP-9 was higher in acute MI versus stable CAD subjects at the time of acute MI: (412 vs. 168 pg/mL, p = 0.002) but not at the quiescent phase follow-up (p > 0.05). MMP-9 was higher at the time of acute MI versus quiescent phase follow-up in acute MI (412 vs. 213 pg/mL, p = 0.001) and atherothrombotic MI specifically (458 vs. 212 pg/mL, p = 0.001). No difference in MMP-2, 3, or 9 was observed between atherothrombotic versus non-atherothrombotic MI subgroups. MMPs-3 and 9 are significantly elevated in acute MI verses stable CAD subjects at time of acute MI but not different at quiescent phase follow-up. MMP-9 is elevated at the time of acute MI and specifically in acute atherothrombotic MI at time of MI versus quiescent phase follow-up.
Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist post-MI or if these measures differ between atherothrombotic versus non-atherothrombotic MI. MMPs-2, 3, and 9 were measured in 80 subjects with acute MI (atherothrombotic and non-atherothrombotic MI) or stable coronary artery disease (CAD). Measurements were made at, the time of acute MI, and > 3-month following acute MI (quiescent phase). Outcome measures were compared between groups and between time of acute MI and quiescent post-MI follow-up using Wilcoxon's and repeated measures analysis of variance. Forty-nine subjects met the criteria for acute MI with clearly defined atherothrombotic (n = 22) and non-atherothrombotic (n = 12) subsets. Fifteen subjects met criteria for stable CAD. MMP-3 was higher in acute MI versus stable CAD subjects at the time of acute MI: (453 vs. 217 pg/mL, p = 0.010) but not at quiescent phase follow-up (p > 0.05). MMP-9 was higher in acute MI versus stable CAD subjects at the time of acute MI: (412 vs. 168 pg/mL, p = 0.002) but not at the quiescent phase follow-up (p > 0.05). MMP-9 was higher at the time of acute MI versus quiescent phase follow-up in acute MI (412 vs. 213 pg/mL, p = 0.001) and atherothrombotic MI specifically (458 vs. 212 pg/mL, p = 0.001). No difference in MMP-2, 3, or 9 was observed between atherothrombotic versus non-atherothrombotic MI subgroups. MMPs-3 and 9 are significantly elevated in acute MI verses stable CAD subjects at time of acute MI but not different at quiescent phase follow-up. MMP-9 is elevated at the time of acute MI and specifically in acute atherothrombotic MI at time of MI versus quiescent phase follow-up.
Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist post-MI or if these measures differ between atherothrombotic versus non-atherothrombotic MI. MMPs-2, 3, and 9 were measured in 80 subjects with acute MI (atherothrombotic and non-atherothrombotic MI) or stable coronary artery disease (CAD). Measurements were made at, the time of acute MI, and > 3-month following acute MI (quiescent phase). Outcome measures were compared between groups and between time of acute MI and quiescent post-MI follow-up using Wilcoxon's and repeated measures analysis of variance. Forty-nine subjects met the criteria for acute MI with clearly defined atherothrombotic (n = 22) and non-atherothrombotic (n = 12) subsets. Fifteen subjects met criteria for stable CAD. MMP-3 was higher in acute MI versus stable CAD subjects at the time of acute MI: (453 vs. 217 pg/mL, p = 0.010) but not at quiescent phase follow-up (p > 0.05). MMP-9 was higher in acute MI versus stable CAD subjects at the time of acute MI: (412 vs. 168 pg/mL, p = 0.002) but not at the quiescent phase follow-up (p > 0.05). MMP-9 was higher at the time of acute MI versus quiescent phase follow-up in acute MI (412 vs. 213 pg/mL, p = 0.001) and atherothrombotic MI specifically (458 vs. 212 pg/mL, p = 0.001). No difference in MMP-2, 3, or 9 was observed between atherothrombotic versus non-atherothrombotic MI subgroups. MMPs-3 and 9 are significantly elevated in acute MI verses stable CAD subjects at time of acute MI but not different at quiescent phase follow-up. MMP-9 is elevated at the time of acute MI and specifically in acute atherothrombotic MI at time of MI versus quiescent phase follow-up.Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist post-MI or if these measures differ between atherothrombotic versus non-atherothrombotic MI. MMPs-2, 3, and 9 were measured in 80 subjects with acute MI (atherothrombotic and non-atherothrombotic MI) or stable coronary artery disease (CAD). Measurements were made at, the time of acute MI, and > 3-month following acute MI (quiescent phase). Outcome measures were compared between groups and between time of acute MI and quiescent post-MI follow-up using Wilcoxon's and repeated measures analysis of variance. Forty-nine subjects met the criteria for acute MI with clearly defined atherothrombotic (n = 22) and non-atherothrombotic (n = 12) subsets. Fifteen subjects met criteria for stable CAD. MMP-3 was higher in acute MI versus stable CAD subjects at the time of acute MI: (453 vs. 217 pg/mL, p = 0.010) but not at quiescent phase follow-up (p > 0.05). MMP-9 was higher in acute MI versus stable CAD subjects at the time of acute MI: (412 vs. 168 pg/mL, p = 0.002) but not at the quiescent phase follow-up (p > 0.05). MMP-9 was higher at the time of acute MI versus quiescent phase follow-up in acute MI (412 vs. 213 pg/mL, p = 0.001) and atherothrombotic MI specifically (458 vs. 212 pg/mL, p = 0.001). No difference in MMP-2, 3, or 9 was observed between atherothrombotic versus non-atherothrombotic MI subgroups. MMPs-3 and 9 are significantly elevated in acute MI verses stable CAD subjects at time of acute MI but not different at quiescent phase follow-up. MMP-9 is elevated at the time of acute MI and specifically in acute atherothrombotic MI at time of MI versus quiescent phase follow-up.
Author Aladili, Bahjat N.
Amraotkar, Alok Ravindra
Owolabi, Ugochukwu Shola
Trainor, Patrick James
Singh, Ayesha
Mitra, Riten
DeFilippis, Andrew Paul
Coulter, Amanda R.
Singam, Narayana Sarma V.
AuthorAffiliation 5 School of Medicine, University of Louisville, Louisville, KY, USA
3 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA
4 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA
2 Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA
1 Diabetes & Obesity Center, University of Louisville, Louisville, KY, USA
6 Applied Statistics, EASIB Department, New Mexico State University, Las Cruces, NM, USA
7 Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA
AuthorAffiliation_xml – name: 1 Diabetes & Obesity Center, University of Louisville, Louisville, KY, USA
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– name: 5 School of Medicine, University of Louisville, Louisville, KY, USA
– name: 3 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA
– name: 6 Applied Statistics, EASIB Department, New Mexico State University, Las Cruces, NM, USA
– name: 7 Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31808123$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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IEDL.DBID U2A
ISSN 0929-5305
1573-742X
IngestDate Thu Aug 21 18:33:58 EDT 2025
Sun Aug 24 04:13:03 EDT 2025
Sat Aug 23 13:28:28 EDT 2025
Wed Feb 19 02:23:50 EST 2025
Thu Apr 24 22:58:29 EDT 2025
Tue Jul 01 02:26:43 EDT 2025
Fri Feb 21 02:36:52 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
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Issue 2
Keywords Extracellular matrix
Atherothrombosis
Acute myocardial infarction
Metalloproteinases
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-7edfb93e0e4a1391ed2d4d1220e3fda5956fa8b16fe283a4e78e5b4e9f37557b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Author contributions Conception and design: U.S.O., A.P.D. Collection and assembly of data: A.R.A, U.S.O., P.J.T., A.P.D. Drafting of article: U.S.O., A.R.A., A.R.C., N.S.V.S., B.N.A., A.S., P.J.T., R.M., A.P.D. Critical revision for important intellectual content: U.S.O., A.R.A., A.R.C., N.S.V.S., B.N.A., A.S., P.J.T., R.M., A.P.D. Administrative, technical, or logistic support: A.P.D, R.M.
This study was carried out at University of Louisville, Division of Cardiovascular Medicine, Louisville, KY 40202, KentuckyOne Health Jewish Hospital, Louisville, KY 40202, and KentuckyOne University of Louisville Hospital, Louisville, KY 40202.
ORCID 0000-0002-5501-8801
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/9012982
PMID 31808123
PQID 2344130028
PQPubID 44413
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9012982
proquest_miscellaneous_2322743664
proquest_journals_2344130028
pubmed_primary_31808123
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PublicationSubtitle A Journal for Translation, Application and Therapeutics in Thrombosis and Vascular Science
PublicationTitle Journal of thrombosis and thrombolysis
PublicationTitleAbbrev J Thromb Thrombolysis
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Snippet Elevated measures of matrix metalloproteinases (MMPs) are associated with acute myocardial infarction (MI), but it is not known how long these changes persist...
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SubjectTerms Adult
Aged
Atherosclerosis - blood
Atherosclerosis - diagnostic imaging
Biomarkers - blood
Cardiology
Cardiovascular disease
Cohort Studies
Coronary artery
Electrocardiography
Female
Follow-Up Studies
Gelatinase A
Gelatinase B
Health risk assessment
Heart attacks
Heart diseases
Hematology
Humans
Male
Matrix metalloproteinase
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 3 - blood
Matrix Metalloproteinase 9 - blood
Medicine
Medicine & Public Health
Metalloproteinase
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnostic imaging
Prospective Studies
Stromelysin 1
Thrombosis - blood
Thrombosis - diagnostic imaging
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Title Change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction
URI https://link.springer.com/article/10.1007/s11239-019-02004-7
https://www.ncbi.nlm.nih.gov/pubmed/31808123
https://www.proquest.com/docview/2344130028
https://www.proquest.com/docview/2322743664
https://pubmed.ncbi.nlm.nih.gov/PMC9012982
Volume 49
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