Mitochondrial genome alterations in rectal and sigmoid carcinomas

Abstract The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310, ND1 and ND5 mi...

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Published inCancer letters Vol. 280; no. 1; pp. 38 - 43
Main Authors Pinheiro, Manuela, Veiga, Isabel, Pinto, Carla, Afonso, Luís, Sousa, Olga, Fragoso, Maria, Santos, Lúcio, Lopes, Paula, Pais, Irene, Lopes, Carlos, Teixeira, Manuel R
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LanguageEnglish
Published Ireland Elsevier Ireland Ltd 18.07.2009
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Abstract Abstract The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310, ND1 and ND5 microsatellite sequence alterations and nuclear microsatellite instability in a series of 38 rectal carcinomas as compared to a series of 25 sigmoid carcinomas. D310 sequence alterations were observed in 34.3% and 37.5% of rectal and sigmoid carcinomas, respectively, whereas ND1 mutations were present in 2.6% in RC and ND5 mutations were detected in 5.3% and 8% of rectal and sigmoid carcinomas, respectively. A trend toward an association between nuclear and mitochondrial microsatellite instability was observed in sigmoid but not in rectal cancers. In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis.
AbstractList The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310, ND1 and ND5 microsatellite sequence alterations and nuclear microsatellite instability in a series of 38 rectal carcinomas as compared to a series of 25 sigmoid carcinomas. D310 sequence alterations were observed in 34.3% and 37.5% of rectal and sigmoid carcinomas, respectively, whereas ND1 mutations were present in 2.6% in RC and ND5 mutations were detected in 5.3% and 8% of rectal and sigmoid carcinomas, respectively. A trend toward an association between nuclear and mitochondrial microsatellite instability was observed in sigmoid but not in rectal cancers. In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis.
The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310,ND1andND5microsatellite sequence alterations and nuclear microsatellite instability in a series of 38 rectal carcinomas as compared to a series of 25 sigmoid carcinomas. D310 sequence alterations were observed in 34.3% and 37.5% of rectal and sigmoid carcinomas, respectively, whereasND1mutations were present in 2.6% in RC andND5mutations were detected in 5.3% and 8% of rectal and sigmoid carcinomas, respectively. A trend toward an association between nuclear and mitochondrial microsatellite instability was observed in sigmoid but not in rectal cancers. In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis.
The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310, ND1 and ND5 microsatellite sequence alterations and nuclear microsatellite instability in a series of 38 rectal carcinomas as compared to a series of 25 sigmoid carcinomas. D310 sequence alterations were observed in 34.3% and 37.5% of rectal and sigmoid carcinomas, respectively, whereas ND1 mutations were present in 2.6% in RC and ND5 mutations were detected in 5.3% and 8% of rectal and sigmoid carcinomas, respectively. A trend toward an association between nuclear and mitochondrial microsatellite instability was observed in sigmoid but not in rectal cancers. In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis.
Abstract The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310, ND1 and ND5 microsatellite sequence alterations and nuclear microsatellite instability in a series of 38 rectal carcinomas as compared to a series of 25 sigmoid carcinomas. D310 sequence alterations were observed in 34.3% and 37.5% of rectal and sigmoid carcinomas, respectively, whereas ND1 mutations were present in 2.6% in RC and ND5 mutations were detected in 5.3% and 8% of rectal and sigmoid carcinomas, respectively. A trend toward an association between nuclear and mitochondrial microsatellite instability was observed in sigmoid but not in rectal cancers. In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis.
Author Teixeira, Manuel R
Afonso, Luís
Sousa, Olga
Lopes, Carlos
Santos, Lúcio
Pinto, Carla
Pinheiro, Manuela
Veiga, Isabel
Fragoso, Maria
Lopes, Paula
Pais, Irene
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Keywords Sigmoid carcinoma
Mitochondrial DNA
Rectal carcinoma
Language English
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Snippet Abstract The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those...
The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant...
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StartPage 38
SubjectTerms Adult
Aged
Apoptosis
Carcinoma - genetics
Carcinoma - metabolism
Cell Nucleus - metabolism
Colorectal cancer
Data analysis
Deoxyribonucleic acid
DNA
DNA Mutational Analysis
DNA, Mitochondrial
Female
Genome, Human
Genomes
Hematology, Oncology and Palliative Medicine
Humans
Male
Microsatellite Repeats
Middle Aged
Mitochondrial DNA
Mutation
Rectal carcinoma
Rectal Neoplasms - genetics
Rectal Neoplasms - metabolism
Sigmoid carcinoma
Sigmoid Neoplasms - genetics
Sigmoid Neoplasms - metabolism
Software
Statistical analysis
Studies
Tumors
Title Mitochondrial genome alterations in rectal and sigmoid carcinomas
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https://dx.doi.org/10.1016/j.canlet.2009.02.009
https://www.ncbi.nlm.nih.gov/pubmed/19269084
https://www.proquest.com/docview/1505482786
https://search.proquest.com/docview/20128573
https://search.proquest.com/docview/67257422
Volume 280
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