Alzheimer's disease: Innate immunity gone awry?

• Published in: Metabolism, clinical and experimental Vol. 69; pp. S41 - S49
• Main Author: VanItallie, Theodore B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017
• Subjects: Acetylation; Adaptive Immunity; Aged; Aged, 80 and over; Alzheimer Disease - immunology; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Alzheimer Disease - prevention & control; Animals; Astrocytes - immunology; Astrocytes - metabolism; Blood-Brain Barrier - immunology; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - physiopathology; Blood–brain barrier; Complement activation; Disease Progression; Endocrinology & Metabolism; Exercise; Hippocampus - immunology; Hippocampus - metabolism; Hippocampus - physiopathology; Histones - metabolism; Humans; Immunity, Innate; Inflammasomes - immunology; Inflammasomes - metabolism; Microglia; Microglia - immunology; Microglia - metabolism; Mitochondria - immunology; Mitochondria - metabolism; Neuroimmunomodulation; Neuroinflammation; Protein Processing, Post-Translational; Synapses - immunology; Synapses - metabolism; β-Hydroxybutyrate; Neuroinflammation; Complement activation; β-Hydroxybutyrate; Blood–brain barrier; Microglia; apoliprotein E4 allele; blood–brain barrier; neuroinflammation; histone deacetylase inhibitor; synaptic pruning; β-hydroxybutyrate; astrocytes; complement activation;ketone esters; NLRP3 inflammasome; microglia; amyloid β oligomers

Inflammation is an immune activity designed to protect the host from pathogens and noxious agents. In its low-intensity form, presence of an inflammatory process must be inferred from appropriate biomarkers. Occult neuroinflammation is not just secondary to Alzheimer's disease (AD) but may cont...