From systems to structure — using genetic data to model protein structures

• Published in: Nature reviews. Genetics Vol. 23; no. 6; pp. 342 - 354
• Main Authors: Braberg, Hannes, Echeverria, Ignacia, Kaake, Robyn M., Sali, Andrej, Krogan, Nevan J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2022; Nature Publishing Group
• Subjects: 631/114/1305; 631/114/2163; 631/1647/1513; 631/535; 631/553/2490/1472; Agriculture; Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Cancer Research; Coevolution; Deep learning; Epistasis, Genetic; Gene Function; Gene mapping; Gene Regulatory Networks; Genetic diversity; Genomes; Human Genetics; Integration; Molecular modelling; Mutation; Peptide mapping; Protein interaction; Protein Interaction Mapping; Protein Interaction Maps; Proteins; Proteins - genetics; Proteins - metabolism; Review; Review Article; Scanning

Understanding the effects of genetic variation is a fundamental problem in biology that requires methods to analyse both physical and functional consequences of sequence changes at systems-wide and mechanistic scales. To achieve a systems view, protein interaction networks map which proteins physica...