Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
(1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper fea...
Saved in:
Published in | Journal of personalized medicine Vol. 11; no. 11; p. 1107 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Basel
MDPI AG
28.10.2021
MDPI |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | (1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory (p < 0.05) between years 5 and 15. From 15 to 30 years of disease onset, cognitive decline continued, affecting global cognition and verbal memory. The baseline measures that best predicted CI were education, disease severity, lesion burden, and hippocampus and anterior cingulate cortex volume. (4) Conclusions: In MS, cognition deteriorates 5 years after disease onset, declining steadily over the next 25 years and more markedly affecting verbal memory. Education, disease severity, lesion burden, and volume of limbic structures predict future CI and may be helpful when identifying at-risk patients. |
---|---|
AbstractList | (1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory (p < 0.05) between years 5 and 15. From 15 to 30 years of disease onset, cognitive decline continued, affecting global cognition and verbal memory. The baseline measures that best predicted CI were education, disease severity, lesion burden, and hippocampus and anterior cingulate cortex volume. (4) Conclusions: In MS, cognition deteriorates 5 years after disease onset, declining steadily over the next 25 years and more markedly affecting verbal memory. Education, disease severity, lesion burden, and volume of limbic structures predict future CI and may be helpful when identifying at-risk patients. (1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory ( p < 0.05) between years 5 and 15. From 15 to 30 years of disease onset, cognitive decline continued, affecting global cognition and verbal memory. The baseline measures that best predicted CI were education, disease severity, lesion burden, and hippocampus and anterior cingulate cortex volume. (4) Conclusions: In MS, cognition deteriorates 5 years after disease onset, declining steadily over the next 25 years and more markedly affecting verbal memory. Education, disease severity, lesion burden, and volume of limbic structures predict future CI and may be helpful when identifying at-risk patients. |
Author | Sepulveda, Maria Alba-Arbalat, Salut Saiz, Albert Solana, Elisabeth Blanco, Yolanda Romero-Pinel, Lucia Solanes, Aleix Andorra, Magi Martínez-Rodríguez, Jose E. Llufriu, Sara Villoslada, Pablo Radua, Joaquim Pulido-Valdeolivas, Irene Montejo, Carmen Martinez-Lapiscina, Elena H. Lopez-Soley, Elisabet Sola-Valls, Nuria Munteis, Elvira Martinez-Heras, Eloy |
AuthorAffiliation | 4 Early Psychosis: Interventions and Clinical-Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London WC2R 2LS, UK 5 Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Bellvitge, IDIBELL, 08907 Barcelona, Spain; lromeropinel@gmail.com 3 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, 171 77 Stockholm, Sweden 2 Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, IDIBAPS and CIBERSAM, 08036 Barcelona, Spain; solanes@clinic.cat (A.S.); radua@clinic.cat (J.R.) 1 Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, 08036 Barcelona, Spain; elopez2@clinic.cat (E.L.-S.); emartind@clinic.cat (E.M.-H.); magiandorra@gmail.com (M.A.); c.montejo.gonzalez@gmail.com (C.M.); sal |
AuthorAffiliation_xml | – name: 6 Neurology Department: Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain; emunteis@parcdesalutmar.cat (E.M.); jemartinezrguez@gmail.com (J.E.M.-R.) – name: 5 Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Bellvitge, IDIBELL, 08907 Barcelona, Spain; lromeropinel@gmail.com – name: 3 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, 171 77 Stockholm, Sweden – name: 4 Early Psychosis: Interventions and Clinical-Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London WC2R 2LS, UK – name: 1 Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, 08036 Barcelona, Spain; elopez2@clinic.cat (E.L.-S.); emartind@clinic.cat (E.M.-H.); magiandorra@gmail.com (M.A.); c.montejo.gonzalez@gmail.com (C.M.); salba@clinic.cat (S.A.-A.); nuria.sola@grupsagessa.com (N.S.-V.); irenepulidovaldeolivas@gmail.com (I.P.-V.); msepulve@clinic.cat (M.S.); yblanco@clinic.cat (Y.B.); elenahmlapiscina@gmail.com (E.H.M.-L.); pvillos@stanford.edu (P.V.); asaiz@clinic.cat (A.S.) – name: 2 Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, IDIBAPS and CIBERSAM, 08036 Barcelona, Spain; solanes@clinic.cat (A.S.); radua@clinic.cat (J.R.) |
Author_xml | – sequence: 1 givenname: Elisabet surname: Lopez-Soley fullname: Lopez-Soley, Elisabet – sequence: 2 givenname: Eloy orcidid: 0000-0001-9937-3162 surname: Martinez-Heras fullname: Martinez-Heras, Eloy – sequence: 3 givenname: Magi surname: Andorra fullname: Andorra, Magi – sequence: 4 givenname: Aleix surname: Solanes fullname: Solanes, Aleix – sequence: 5 givenname: Joaquim orcidid: 0000-0003-1240-5438 surname: Radua fullname: Radua, Joaquim – sequence: 6 givenname: Carmen surname: Montejo fullname: Montejo, Carmen – sequence: 7 givenname: Salut surname: Alba-Arbalat fullname: Alba-Arbalat, Salut – sequence: 8 givenname: Nuria surname: Sola-Valls fullname: Sola-Valls, Nuria – sequence: 9 givenname: Irene surname: Pulido-Valdeolivas fullname: Pulido-Valdeolivas, Irene – sequence: 10 givenname: Maria surname: Sepulveda fullname: Sepulveda, Maria – sequence: 11 givenname: Lucia surname: Romero-Pinel fullname: Romero-Pinel, Lucia – sequence: 12 givenname: Elvira surname: Munteis fullname: Munteis, Elvira – sequence: 13 givenname: Jose E. surname: Martínez-Rodríguez fullname: Martínez-Rodríguez, Jose E. – sequence: 14 givenname: Yolanda surname: Blanco fullname: Blanco, Yolanda – sequence: 15 givenname: Elena H. surname: Martinez-Lapiscina fullname: Martinez-Lapiscina, Elena H. – sequence: 16 givenname: Pablo orcidid: 0000-0002-8735-6119 surname: Villoslada fullname: Villoslada, Pablo – sequence: 17 givenname: Albert surname: Saiz fullname: Saiz, Albert – sequence: 18 givenname: Elisabeth orcidid: 0000-0001-7973-2439 surname: Solana fullname: Solana, Elisabeth – sequence: 19 givenname: Sara orcidid: 0000-0003-4273-9121 surname: Llufriu fullname: Llufriu, Sara |
BackLink | http://kipublications.ki.se/Default.aspx?queryparsed=id:148287164$$DView record from Swedish Publication Index |
BookMark | eNpdkW9rFDEQxoNU7B_7yi8Q8I0gp9lkNsm-EeSqtVBRUN8astnZa87dZJvsVvrtzXmHtA6EGZLfPEyeOSVHIQYk5EXF3gjRsLfbaaz-BlNPyAlnql4BcHn0oD4m5zlvWQldcy7ZM3IsQAuAujkhPy_ugx29y9SGjn5N2Hk3x5Rp7Ok6boKf_R3Sq3GyPo0YZmqHGDZ0vkF64TPajAVbUkk-0M_LMPtpQPrNDZhi9vk5edrbIeP5IZ-RHx8_fF9_Wl1_ubxav79eOVAwr5RD6KvOtXVfCwbIuOMaVGsF0yBb3qm26SXXVljheK9qFL0EtMo1omotijPS7HXzb5yW1kzJjzbdm2h9qWNnDve__O6YjKYCzbWqJJTed_veAozYufLLZIfHEo9egr8xm3hntOQg9U7g1UEgxdsF82xGnx0Ogw0Yl2yK58BYU0le0Jf_odviXijW7CjOtOIgCvV6T7liYk7Y_xumYma3dvNg7eIP2keiCA |
CitedBy_id | crossref_primary_10_1136_jnnp_2023_332332 crossref_primary_10_1038_s41597_023_02421_7 crossref_primary_10_1016_j_ncl_2024_05_010 crossref_primary_10_3390_jpm11121349 crossref_primary_10_3390_jpm12061017 crossref_primary_10_1016_j_msard_2023_104849 crossref_primary_10_1111_ene_15697 crossref_primary_10_3389_fneur_2023_1319869 crossref_primary_10_1007_s00702_024_02786_y |
Cites_doi | 10.1191/1352458506ms1258oa 10.1136/jnnp-2012-304333 10.1016/j.neuroimage.2004.07.051 10.1016/j.neuroimage.2009.04.054 10.1371/journal.pcbi.1005350 10.1016/S1474-4422(08)70259-X 10.1002/brb3.875 10.1177/1352458518771838 10.1148/radiol.2018172808 10.1371/journal.pone.0071058 10.1016/j.nicl.2016.11.026 10.1007/s10072-010-0376-4 10.3389/fneur.2020.623914 10.1016/j.neuroimage.2006.01.021 10.1038/s41583-018-0053-9 10.1016/j.neuropsychologia.2015.01.031 10.1001/jamaneurol.2020.4920 10.1016/j.neuroimage.2008.05.038 10.1177/1352458517717089 10.1080/13803390902740643 10.1177/1352458513475490 10.1177/1352458519878685 10.1177/1352458519860319 10.1212/WNL.33.11.1444 10.1016/j.neuroimage.2017.08.047 10.1212/WNL.0000000000004977 10.1186/1756-0500-7-910 10.1016/j.neuroimage.2020.116956 10.3389/fneur.2020.581700 10.1007/978-1-4612-1694-0_16 10.3389/fneur.2018.00132 10.1080/23279095.2019.1624260 10.1016/S1474-4422(14)70256-X 10.1212/WNL.41.5.685 10.1177/13524585211011390 |
ContentType | Journal Article |
Copyright | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021 |
Copyright_xml | – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 by the authors. 2021 |
DBID | AAYXX CITATION 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M7P PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM ADTPV AOWAS D8T ZZAVC |
DOI | 10.3390/jpm11111107 |
DatabaseName | CrossRef ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea ProQuest Central Student SciTech Premium Collection Biological Sciences Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Freely available online SwePub Articles full text |
DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Biological Science Collection ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest One Academic MEDLINE - Academic |
DatabaseTitleList | Publicly Available Content Database CrossRef |
Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 2075-4426 |
ExternalDocumentID | oai_prod_swepub_kib_ki_se_148287164 10_3390_jpm11111107 |
GroupedDBID | 53G 5VS 8FE 8FH AADQD AAFWJ AAYXX ADBBV AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BBNVY BCNDV BENPR BHPHI CCPQU CITATION DIK EMOBN GROUPED_DOAJ GX1 HCIFZ HYE IAO IHR ITC KQ8 LK8 M48 M7P MODMG M~E OK1 PGMZT PIMPY PROAC RPM ABUWG AZQEC DWQXO GNUQQ PQEST PQQKQ PQUKI PRINS 7X8 5PM RIG ADRAZ ADTPV AOWAS D8T IPNFZ ZZAVC |
ID | FETCH-LOGICAL-c474t-7ce4f1dcb5f5304e02c2847ba30846b2d7b9f628a3a3c2f75e3f64ea7c931bae3 |
IEDL.DBID | RPM |
ISSN | 2075-4426 |
IngestDate | Wed Oct 30 05:01:28 EDT 2024 Tue Sep 17 21:16:53 EDT 2024 Wed Dec 04 07:55:06 EST 2024 Mon Nov 25 22:36:36 EST 2024 Fri Dec 06 09:07:56 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Language | English |
License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c474t-7ce4f1dcb5f5304e02c2847ba30846b2d7b9f628a3a3c2f75e3f64ea7c931bae3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors share co-senior authorship. |
ORCID | 0000-0003-1240-5438 0000-0001-7973-2439 0000-0001-9937-3162 0000-0003-4273-9121 0000-0002-8735-6119 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624684/ |
PMID | 34834459 |
PQID | 2602087243 |
PQPubID | 2032376 |
ParticipantIDs | swepub_primary_oai_prod_swepub_kib_ki_se_148287164 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8624684 proquest_miscellaneous_2604009162 proquest_journals_2602087243 crossref_primary_10_3390_jpm11111107 |
PublicationCentury | 2000 |
PublicationDate | 20211028 |
PublicationDateYYYYMMDD | 2021-10-28 |
PublicationDate_xml | – month: 10 year: 2021 text: 20211028 day: 28 |
PublicationDecade | 2020 |
PublicationPlace | Basel |
PublicationPlace_xml | – name: Basel |
PublicationTitle | Journal of personalized medicine |
PublicationYear | 2021 |
Publisher | MDPI AG MDPI |
Publisher_xml | – name: MDPI AG – name: MDPI |
References | Weygandt (ref_32) 2018; 24 ref_14 Rao (ref_12) 1991; 41 Portaccio (ref_25) 2021; 78 Sepulcre (ref_33) 2009; 47 Keser (ref_35) 2018; 9 Llufriu (ref_30) 2019; 25 Leavitt (ref_23) 2020; 26 Sumowski (ref_4) 2018; 90 Mahad (ref_21) 2015; 14 Eijlers (ref_7) 2018; 288 Schreiber (ref_2) 2018; 8 Amato (ref_3) 2010; 31 Oren (ref_29) 2015; 69 Sumowski (ref_26) 2009; 31 ref_24 Amin (ref_34) 2020; 11 ref_22 Radua (ref_18) 2020; 218 ref_20 Sepulcre (ref_31) 2008; 42 Chiaravalloti (ref_1) 2008; 7 Llufriu (ref_10) 2017; 13 Sepulcre (ref_13) 2006; 12 Heled (ref_6) 2021; 28 Smith (ref_16) 2004; 23 Desikan (ref_15) 2006; 31 Solana (ref_27) 2020; 11 ref_9 Scalfari (ref_19) 2014; 85 Papadopoulou (ref_28) 2013; 19 Fortin (ref_17) 2017; 161 Portaccio (ref_8) 2018; 19 Damasceno (ref_5) 2020; 26 Kurtzke (ref_11) 1983; 33 |
References_xml | – volume: 12 start-page: 187 year: 2006 ident: ref_13 article-title: Cognitive Impairment in Patients with Multiple Sclerosis Using the Brief Repeatable Battery-Neuropsychology Test publication-title: Mult. Scler. doi: 10.1191/1352458506ms1258oa contributor: fullname: Sepulcre – volume: 85 start-page: 67 year: 2014 ident: ref_19 article-title: Onset of Secondary Progressive Phase and Long-Term Evolution of Multiple Sclerosis publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2012-304333 contributor: fullname: Scalfari – volume: 23 start-page: S208 year: 2004 ident: ref_16 article-title: Advances in Functional and Structural MR Image Analysis and Implementation as FSL publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.07.051 contributor: fullname: Smith – volume: 47 start-page: 773 year: 2009 ident: ref_33 article-title: Brain Pathways of Verbal Working Memory: A Lesion-Function Correlation Study publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.04.054 contributor: fullname: Sepulcre – ident: ref_14 doi: 10.1371/journal.pcbi.1005350 – volume: 7 start-page: 1139 year: 2008 ident: ref_1 article-title: Cognitive Impairment in Multiple Sclerosis publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(08)70259-X contributor: fullname: Chiaravalloti – volume: 8 start-page: e00875 year: 2018 ident: ref_2 article-title: Progressive Multiple Sclerosis, Cognitive Function, and Quality of Life publication-title: Brain Behav. doi: 10.1002/brb3.875 contributor: fullname: Schreiber – volume: 25 start-page: 801 year: 2019 ident: ref_30 article-title: Hippocampal-Related Memory Network in Multiple Sclerosis: A Structural Connectivity Analysis publication-title: Mult. Scler. doi: 10.1177/1352458518771838 contributor: fullname: Llufriu – volume: 288 start-page: 544 year: 2018 ident: ref_7 article-title: Determinants of Cognitive Impairment in Patients with Multiple Sclerosis with and without Atrophy publication-title: Radiology doi: 10.1148/radiol.2018172808 contributor: fullname: Eijlers – ident: ref_22 doi: 10.1371/journal.pone.0071058 – volume: 13 start-page: 288 year: 2017 ident: ref_10 article-title: Structural Networks Involved in Attention and Executive Functions in Multiple Sclerosis publication-title: NeuroImage Clin. doi: 10.1016/j.nicl.2016.11.026 contributor: fullname: Llufriu – volume: 31 start-page: 211 year: 2010 ident: ref_3 article-title: Cognitive Impairment in Early Stages of Multiple Sclerosis publication-title: Neurol. Sci. doi: 10.1007/s10072-010-0376-4 contributor: fullname: Amato – volume: 11 start-page: 623914 year: 2020 ident: ref_34 article-title: Thalamic Injury and Cognition in Multiple Sclerosis publication-title: Front. Neurol. doi: 10.3389/fneur.2020.623914 contributor: fullname: Amin – volume: 31 start-page: 968 year: 2006 ident: ref_15 article-title: An Automated Labeling System for Subdividing the Human Cerebral Cortex on MRI Scans into Gyral Based Regions of Interest publication-title: Neuroimage doi: 10.1016/j.neuroimage.2006.01.021 contributor: fullname: Desikan – volume: 19 start-page: 599 year: 2018 ident: ref_8 article-title: Multiple Sclerosis and Cognition: Synaptic Failure and Network Dysfunction publication-title: Nat. Rev. Neurosci. doi: 10.1038/s41583-018-0053-9 contributor: fullname: Portaccio – volume: 69 start-page: 39 year: 2015 ident: ref_29 article-title: Distinct Functional Connectivity of the Hippocampus during Semantic and Phonemic Fluency publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2015.01.031 contributor: fullname: Oren – volume: 78 start-page: 414 year: 2021 ident: ref_25 article-title: Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2020.4920 contributor: fullname: Portaccio – volume: 42 start-page: 1237 year: 2008 ident: ref_31 article-title: Mapping the Brain Pathways of Declarative Verbal Memory: Evidence from White Matter Lesions in the Living Human Brain publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.05.038 contributor: fullname: Sepulcre – volume: 24 start-page: 1163 year: 2018 ident: ref_32 article-title: Brain Activity, Regional Gray Matter Loss, and Decision-Making in Multiple Sclerosis publication-title: Mult. Scler. doi: 10.1177/1352458517717089 contributor: fullname: Weygandt – volume: 31 start-page: 913 year: 2009 ident: ref_26 article-title: Cognitive Reserve Protects against Cognitive Dysfunction in Multiple Sclerosis publication-title: J. Clin. Exp. Neuropsychol. doi: 10.1080/13803390902740643 contributor: fullname: Sumowski – volume: 19 start-page: 1290 year: 2013 ident: ref_28 article-title: Contribution of Cortical and White Matter Lesions to Cognitive Impairment in Multiple Sclerosis publication-title: Mult. Scler. doi: 10.1177/1352458513475490 contributor: fullname: Papadopoulou – volume: 26 start-page: 1740 year: 2020 ident: ref_5 article-title: Cognitive Trajectories in Relapsing–remitting Multiple Sclerosis: A Longitudinal 6-Year Study publication-title: Mult. Scler. doi: 10.1177/1352458519878685 contributor: fullname: Damasceno – volume: 26 start-page: 1247 year: 2020 ident: ref_23 article-title: Dissociable Cognitive Patterns Related to Depression and Anxiety in Multiple Sclerosis publication-title: Mult. Scler. J. doi: 10.1177/1352458519860319 contributor: fullname: Leavitt – volume: 33 start-page: 1444 year: 1983 ident: ref_11 article-title: Rating Neurologic Impairment in Multiple Sclerosis: An Expanded Disability Status Scale (EDSS) publication-title: Neurology doi: 10.1212/WNL.33.11.1444 contributor: fullname: Kurtzke – volume: 161 start-page: 149 year: 2017 ident: ref_17 article-title: Harmonization of Multi-Site Diffusion Tensor Imaging Data publication-title: Neuroimage doi: 10.1016/j.neuroimage.2017.08.047 contributor: fullname: Fortin – volume: 90 start-page: 278 year: 2018 ident: ref_4 article-title: Cognition in Multiple Sclerosis: State of the Field and Priorities for the Future publication-title: Neurology doi: 10.1212/WNL.0000000000004977 contributor: fullname: Sumowski – ident: ref_9 doi: 10.1186/1756-0500-7-910 – volume: 218 start-page: 116956 year: 2020 ident: ref_18 article-title: Increased Power by Harmonizing Structural MRI Site Differences with the ComBat Batch Adjustment Method in ENIGMA publication-title: Neuroimage doi: 10.1016/j.neuroimage.2020.116956 contributor: fullname: Radua – volume: 11 start-page: 581700 year: 2020 ident: ref_27 article-title: Impact of Cognitive Reserve and Structural Connectivity on Cognitive Performance in Multiple Sclerosis publication-title: Front. Neurol. doi: 10.3389/fneur.2020.581700 contributor: fullname: Solana – ident: ref_20 doi: 10.1007/978-1-4612-1694-0_16 – volume: 9 start-page: 132 year: 2018 ident: ref_35 article-title: Quantitative Limbic System Mapping of Main Cognitive Domains in Multiple Sclerosis publication-title: Front. Neurol. doi: 10.3389/fneur.2018.00132 contributor: fullname: Keser – volume: 28 start-page: 210 year: 2021 ident: ref_6 article-title: Cognitive Functions and Disability Progression in Relapsing-Remitting Multiple Sclerosis: A Longitudinal Study publication-title: Appl. Neuropsychol. Adult doi: 10.1080/23279095.2019.1624260 contributor: fullname: Heled – volume: 14 start-page: 183 year: 2015 ident: ref_21 article-title: Pathological Mechanisms in Progressive Multiple Sclerosis publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(14)70256-X contributor: fullname: Mahad – volume: 41 start-page: 685 year: 1991 ident: ref_12 article-title: Cognitive Dysfunction in Multiple Sclerosis. I. Frequency, Patterns, and Prediction publication-title: Neurology doi: 10.1212/WNL.41.5.685 contributor: fullname: Rao – ident: ref_24 doi: 10.1177/13524585211011390 |
SSID | ssj0000852260 |
Score | 2.298709 |
Snippet | (1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal... |
SourceID | swepub pubmedcentral proquest crossref |
SourceType | Open Access Repository Aggregation Database |
StartPage | 1107 |
SubjectTerms | Age Cognition & reasoning Cognitive ability Cortex (cingulate) Cortex (temporal) Datasets Information processing Learning algorithms Machine learning Magnetic resonance imaging Medicin och hälsovetenskap Memory Multiple sclerosis Neuroimaging Patients Precision medicine Semantics Software Variables Volumetric analysis |
SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEB7SDZReSpq2dJu0qJCriS3Jln0KzYu0sCEkDeRUo2frPuztevP_O2NrN9keajAGy0ZiRtJ889AMwEEw1rqiEgm3xiWy0FlSWu-SwpgQMperKtBB4dllcXErP9_ld9Hg1sewytWeOGzUrrNkIz9E3M3TUnEpjuZ_EqoaRd7VWELjCWzzTJTlBLaPzy6vrtdWFgQUiC_S8WCeQP3-8Mf8dzZcVED2sSh6wJf_Rkdu5BAd5M75DjyPgJF9HDn8ArZ8uwtPZ9El_hK-no415XumW8euFtRAFXRYF9jJKjaIfcJV3yzIEsj0r679xhD3sdPROcOobh0-mpbNYnghu8G-cNBN_wpuz8--nFwksWhCYqWSy0RZL5HI1uQhF6n0KbckgYwWKUINw50yVSh4qYUWlgeVexEK6bWylciM9uI1TNqu9W-AZVpxK7VyuRHSpUErBGe5rpwrpTaST-FgRb96PubGqFGnIDLXj8g8hf0Vbeu4QPr6gZ1T-LBuxqlN_grd-u5--AZ3GMSv2JPa4Mm6O0qOvdnSNt-HJNl08KUo5RT4yL3NX1A41fH9z4buuvc1pUQd9Me3_x_xHjzjFNmCEoyX-zBZLu79O4QmS_M-zr-_CnXqgw priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3pS-UwEA-iIPtFvJZ9XkTwa9c2SZv2g4g8FRWeCO4DP23JudajT98B-t8700OtLBZKoWmYMJN0fpPMQcie18bYJOMBM9oGIlFRkBpng0Rr7yMby8xjoPDgMjkbioub-GaOtMU4GwZO_mvaYT2p4fjh98vz6yEs-AO0OMFk3797eoyqC6PKFxioRPTtGjQ4_652xgKYEdbxeV_7dDXSB8z86iTZSSVaqZ_TZbLU4EZ6VAt6hcy5cpUsDpqT8TXy97guLT-hqrT0aowNWEiHjjztty5C9BwWfzHGDUGqHkblPwrwjx7XZzQUy9fBoyjpoPEypNdACwZdTNbJ8PTkT_8saGonBEZIMQ2kcQJ4bXTsYx4KFzKDikgrHgLi0MxKnfmEpYorbpiXseM-EU5Jk_FIK8d_kvlyVLpfhEZKMiOUtLHmwoZeScBoscqsTYXSgvXIXsu__KlOkZGDaYFszj-xuUe2Wt7mrZhzEAoLUwky65Hd92aY4XhsoUo3mlXfwI8GYCxQkh2ZvJPDHNndlrK4rXJlY_xLkooeYbX0ul1AR-XN-_sC73zicsyMWpmRG9-PeJP8YOjgAoqMpVtkfjqeuW1AKFO9U82-N3cS61Y priority: 102 providerName: Scholars Portal |
Title | Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis |
URI | https://www.proquest.com/docview/2602087243 https://search.proquest.com/docview/2604009162 https://pubmed.ncbi.nlm.nih.gov/PMC8624684 http://kipublications.ki.se/Default.aspx?queryparsed=id:148287164 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED-aDsZexj5Z1i5o0Fc3tiRb9mOXfoNL2FbI04w-O3eNEpL0_9_JH12yxxpsg2Vz4nTy3Um_uwM4ckprkxUsolqZiGcyiXJtTZQp5VxiUlG4EChc3mSXt_x6ls72IO1jYRrQvlb1sX-YH_v6d4OtXM71uMeJjaflJAQ1ZDkfD2CA6nfLRb9vgVdoUsRtLB5Dl358v5wnzRGHknssLJ_xkJt0WxH9sy7_x0buZBBttM75G3jdmYvkpO3WW9iz_h28LLsN8ffw67StKL8m0hsyXYWGUD-HLByZ9MggcoVzvl6FdUAiHxb-jqDVR07brRkSqtbhrfak7MCF5AfSwk7X6w9we372c3IZdSUTIs0F30RCW44s1ip1KYu5jakO-kdJFqOhoagRqnAZzSWTTFMnUstcxq0UumCJkpZ9hH2_8PYTkEQKqrkUJlWMm9hJgaZZKgtjci4Vp0M46vlXLdvMGBV6FIHj1RbHh3DY87bqpse6wvGhcS4oZ0P4-tSMgh12K6S3i8fmHfy_oPWKlMTOmDyRC6mxd1tQYpoU2Z2EDIG2o7f7Caqmqnv-pw5ntbZVSIjaeI-fn03uAF7RAHlB1UbzQ9jfrB7tF7RZNmoEL76d3Uy_j2BwMUvwWvJ81MjtXy4G9Zw |
link.rule.ids | 230,314,727,780,784,885,2221,21388,24318,27924,27925,33744,33745,43805,53791,53793,74302 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Zb9QwELZgKwEvFadYWsBIfY2a2E6cPKHSQ1voripopT5h-SzhSJbN9v93JvFuuzwQKYoUJ7I1Y3u-OTxDyF4w1rqi4gmzxiWi0FlSWu-SwpgQMpfLKuBB4emsmFyKz1f5VTS4dTGscrUn9hu1ay3ayPcBd7O0lEzwj_O_CVaNQu9qLKHxkGxh5vR8RLY-Hc_Ov66tLAAoAF-kw8E8Dvr9_s_5n6y_sIDsfVF0hy__jY7cyCHay52Tp2Q7AkZ6MHD4GXngm-fk0TS6xF-Q70dDTfmO6sbR8wU2YAUd2gZ6uIoNoqew6usFWgKp_t021xRwHz0anDMU69bBo27oNIYX0m_QFwy67l6Sy5Pji8NJEosmJFZIsUyk9QKIbE0ecp4KnzKLEshongLUMMxJU4WClZprblmQueehEF5LW_HMaM9fkVHTNv41oZmWzAotXW64cGnQEsBZrivnSqGNYGOyt6Kfmg-5MRToFEhmdY_MY7K7oq2KC6RTd-wckw_rZpja6K_QjW9v-m9ghwH8Cj3JDZ6su8Pk2JstTf2jT5KNB1-KUowJG7i3-QsIJxXf_6rxVp1XmBK11x_f_H_E78njycX0TJ2dzr7skCcMo1xAmrFyl4yWixv_FmDK0ryLc_EWI27taw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJ028ID5FYYCR9ho1sZ04eUKwrtqAVhUwaU9Y_hzhIylN9_9zTtxu5YFIUaQ4kaM75-5n3_l-AMdeG2OLiiXUaJvwQmVJaZxNCq29z2wuKh82Cs8XxdkF_3CZX8b8py6mVW5tYm-obWvCGvkEcTdNS0E5m_iYFrGczt6u_iSBQSpEWiOdxl04QK-Y0hEcvD9dLD_vVlwQXCDWSIdNegzn-pMfq99ZfwQy2dtu6QZr_pspuVdPtPdBswdwP4JH8m7Q9kO445pHcDiP4fHH8G068Mt3RDWWLNehIbDpkNaTk22eEDlHC1Cvw6ogUb_a5oogBiTTIVBDAocdXuqGzGOqIfmCfeFH190TuJidfj05SyKBQmK44JtEGMdR4EbnPmcpdyk1wRtpxVKEHZpaoStf0FIxxQz1InfMF9wpYSqWaeXYUxg1beOeAcmUoIYrYXPNuE29EgjUclVZW3KlOR3D8VZ-cjXUyZA4vwhilrfEPIajrWxl_Fk6eaPaMbzZNeMwD7EL1bj2un8GrQ1iWexJ7Olk110olL3f0tTf-4LZYRNMUfIx0EF7-6-go5Lx_s86nLJzMpRH7eeSz___xa_hEIeh_HS--PgC7tGQ8IKOjZZHMNqsr91LRCwb_SoOxb_ROPGY |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dynamics+and+Predictors+of+Cognitive+Impairment+along+the+Disease+Course+in+Multiple+Sclerosis&rft.jtitle=Journal+of+personalized+medicine&rft.au=Lopez-Soley%2C+Elisabet&rft.au=Martinez-Heras%2C+Eloy&rft.au=Magi+Andorra&rft.au=Solanes%2C+Aleix&rft.date=2021-10-28&rft.pub=MDPI+AG&rft.eissn=2075-4426&rft.volume=11&rft.issue=11&rft.spage=1107&rft_id=info:doi/10.3390%2Fjpm11111107&rft.externalDBID=HAS_PDF_LINK |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2075-4426&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2075-4426&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2075-4426&client=summon |