Body Fat Distribution and the Risk of Incident Metabolic Syndrome: A Longitudinal Cohort Study
The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudina...
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| Published in | Scientific reports Vol. 7; no. 1; pp. 10955 - 8 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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London
Nature Publishing Group UK
08.09.2017
Nature Publishing Group |
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| Abstract | The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29–1.74), and the adjusted HR of the 5
th
VAT quintile compared with the 1
st
quintile was 3.73 (95% CI 2.22–6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components. |
|---|---|
| AbstractList | The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29-1.74), and the adjusted HR of the 5th VAT quintile compared with the 1st quintile was 3.73 (95% CI 2.22-6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components.The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29-1.74), and the adjusted HR of the 5th VAT quintile compared with the 1st quintile was 3.73 (95% CI 2.22-6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components. The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29–1.74), and the adjusted HR of the 5 th VAT quintile compared with the 1 st quintile was 3.73 (95% CI 2.22–6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components. The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29–1.74), and the adjusted HR of the 5th VAT quintile compared with the 1st quintile was 3.73 (95% CI 2.22–6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components. The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29-1.74), and the adjusted HR of the 5 VAT quintile compared with the 1 quintile was 3.73 (95% CI 2.22-6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components. |
| ArticleNumber | 10955 |
| Author | Kim, Joo Sung Kwon, Hyuktae Kim, Donghee |
| Author_xml | – sequence: 1 givenname: Hyuktae surname: Kwon fullname: Kwon, Hyuktae organization: Department of Family Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Department of Family Medicine, Seoul National University Hospital & College of Medicine – sequence: 2 givenname: Donghee orcidid: 0000-0003-1919-6800 surname: Kim fullname: Kim, Donghee email: messmd@chol.com organization: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford – sequence: 3 givenname: Joo Sung surname: Kim fullname: Kim, Joo Sung organization: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28887474$$D View this record in MEDLINE/PubMed |
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TrayhurnPHypoxia and Adipose Tissue Function and Dysfunction in ObesityPhysiological Reviews2013931211:CAS:528:DC%2BC3sXhvFKnsro%3D10.1152/physrev.00017.201223303904 AbrahamTMPedleyAMassaroJMHoffmannUFoxCSAssociation between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factorsCirculation2015132163916471:CAS:528:DC%2BC2MXhslGltrnF10.1161/CIRCULATIONAHA.114.015000262946604779497 KimDBody Fat Distribution and Risk of Incident and Regressed Nonalcoholic Fatty Liver DiseaseClinical Gastroenterology and Hepatology201614132138.e13410.1016/j.cgh.2015.07.02426226099 World Health Organization. The Asia-Pacific perspective: redefining obesity and its treatment (2000). 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Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity2009120164016451:CAS:528:DC%2BD1MXht1OrtrrK LakkaHMThe metabolic syndrome and total and cardiovascular disease mortality in middle-aged menJAMA20022882709271610.1001/jama.288.21.270912460094 DeschênesDCouturePDupontPTchernofASubdivision of the Subcutaneous Adipose Tissue Compartment and Lipid-Lipoprotein Levels in WomenObesity research20031146947610.1038/oby.2003.6412634447 GrundySMDiagnosis and Management of the Metabolic SyndromeAn American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement200511227352752 SongSWRelationships between visceral adipose tissue measurement site and the metabolic syndrome in the Korean populationObes Res Clin Pract20104e24734210.1016/j.orcp.2010.07.00124345690 OkaRImpact of visceral adipose tissue and subcutaneous adipose tissue on insulin resistance in middle-aged JapaneseJ Atheroscler Thromb2012198148221:CAS:528:DC%2BC3sXitFartg%3D%3D10.5551/jat.1229422813532 LeeJJPedleyAHoffmannUMassaroJMFoxCSAssociation of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk FactorsJournal of the American College of Cardiology2016681509152110.1016/j.jacc.2016.06.06727687192 WildmanRPSubcutaneous adipose tissue in relation to subclinical atherosclerosis and cardiometabolic risk factors in midlife womenThe American journal of clinical nutrition2011937197261:CAS:528:DC%2BC3MXjvFahurY%3D10.3945/ajcn.110.007153213460893057544 WangJThe metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic FinnsEuropean Heart Journal20072885786410.1093/eurheartj/ehl52417303589 GolanRAbdominal superficial subcutaneous fat: a putative distinct protective fat subdepot in type 2 diabetesDiabetes care2012356406471:CAS:528:DC%2BC38XltFGksLg%3D10.2337/dc11-1583223446123322677 YimJYSagittal Abdominal Diameter Is a Strong Anthropometric Measure of Visceral Adipose Tissue in the Asian General PopulationDiabetes care2010332665267010.2337/dc10-0606208439762992209 DespresJ-PLemieuxIAbdominal obesity and metabolic syndromeNature20064448818872006Natur.444..881D1:CAS:528:DC%2BD28XhtlShtrzF10.1038/nature0548817167477 VirtanenKADifferential Effects of Rosiglitazone and Metformin on Adipose Tissue Distribution and Glucose Uptake in Type 2 Diabetic SubjectsDiabetes2003522832901:CAS:528:DC%2BD3sXhtFagu7c%3D10.2337/diabetes.52.2.28312540598 PorterSAAbdominal subcutaneous adipose tissue: a protective fat depot?Diabetes care2009321068107510.2337/dc08-2280192440872681034 CornierM-AAssessing AdiposityA Scientific Statement From the American Heart Association201112419962019 IbrahimMMSubcutaneous and visceral adipose tissue: structural and functional differencesObesity 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Gene Expression of Serum Adipokines That Predict Type 2 DiabetesObesity2010188848891:CAS:528:DC%2BC3cXlt1ahsbY%3D10.1038/oby.2009.44320019678 FoxCSAbdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart StudyCirculation2007116394810.1161/CIRCULATIONAHA.106.67535517576866 CarrDBIntra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic SyndromeDiabetes200453208720941:CAS:528:DC%2BD2cXmtFGqtrk%3D10.2337/diabetes.53.8.208715277390 LiuJImpact of abdominal visceral and subcutaneous adipose tissue on cardiometabolic risk factors: the Jackson Heart StudyJ Clin Endocrinol Metab201095541954261:CAS:528:DC%2BC3cXhs1arsLnJ10.1210/jc.2010-1378208439522999970 KangSMAndroid fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly peoplePloS one201162011PLoSO...627694K1:CAS:528:DC%2BC3MXhsF2isLvP10.1371/journal.pone.0027694220966133214067 ChungSJMetabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-upsGut200857136013651:STN:280:DC%2BD1crpvF2rug%3D%3D10.1136/gut.2007.14709018441006 J Wang (9723_CR4) 2007; 28 K Samaras (9723_CR29) 2010; 18 KA Virtanen (9723_CR31) 2003; 52 O Bosello (9723_CR30) 2000; 1 M-A Cornier (9723_CR26) 2011; 124 YM Nakao (9723_CR16) 2012; 88 TM Abraham (9723_CR21) 2015; 132 SW Song (9723_CR20) 2010; 4 JJ Lee (9723_CR22) 2016; 68 S Kim (9723_CR19) 2011; 34 SW Oh (9723_CR5) 2011; 35 DB Carr (9723_CR25) 2004; 53 GE Chung (9723_CR36) 2015; 94 CS Fox (9723_CR12) 2007; 116 A Mozumdar (9723_CR6) 2011; 34 D Kim (9723_CR35) 2016; 14 SM Kang (9723_CR24) 2011; 6 SA Porter (9723_CR13) 2009; 32 RV Shah (9723_CR23) 2014; 7 J-P Despres (9723_CR17) 2006; 444 M-S Kwak (9723_CR38) 2015; 35 9723_CR1 R Oka (9723_CR10) 2012; 19 IJ Neeland (9723_CR9) 2013; 21 MM Ibrahim (9723_CR18) 2010; 11 J Koska (9723_CR34) 2008; 16 SM Grundy (9723_CR40) 2005; 112 RP Wildman (9723_CR15) 2011; 93 M-S Kwak (9723_CR37) 2017; 37 J Liu (9723_CR14) 2010; 95 P Trayhurn (9723_CR27) 2013; 93 R Golan (9723_CR32) 2012; 35 D Deschênes (9723_CR33) 2003; 11 HM Lakka (9723_CR3) 2002; 288 T McLaughlin (9723_CR11) 2011; 96 SJ Chung (9723_CR39) 2008; 57 T Di Chiara (9723_CR28) 2012; 2012 9723_CR41 KGMM Alberti (9723_CR7) 2009; 120 N Ouchi (9723_CR2) 2011; 11 JY Yim (9723_CR8) 2010; 33 |
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| Snippet | The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the... |
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| SubjectTerms | 692/163/2743/2037 692/163/2743/393 Adipose tissue Adult Blood Glucose - analysis Blood Pressure Body fat Body Fat Distribution Cohort analysis Female Humanities and Social Sciences Humans Hypertension Intra-Abdominal Fat - anatomy & histology Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - epidemiology Middle Aged multidisciplinary Science Science (multidisciplinary) Subcutaneous Fat - anatomy & histology Sugar Triglycerides Triglycerides - blood |
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| Title | Body Fat Distribution and the Risk of Incident Metabolic Syndrome: A Longitudinal Cohort Study |
| URI | https://link.springer.com/article/10.1038/s41598-017-09723-y https://www.ncbi.nlm.nih.gov/pubmed/28887474 https://www.proquest.com/docview/1953983312 https://www.proquest.com/docview/1937530715 https://pubmed.ncbi.nlm.nih.gov/PMC5591218 |
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