Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34

• Published in: Cell reports (Cambridge) Vol. 30; no. 8; pp. 2807 - 2819.e4
• Main Authors: Xie, Weihong, Jin, Shouheng, Wu, Yaoxing, Xian, Huifang, Tian, Shuo, Liu, Di-Ao, Guo, Zhiyong, Cui, Jun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.02.2020; Elsevier
• Subjects: auto-ubiquitination; Autophagy; Cell Line; Class III Phosphatidylinositol 3-Kinases - metabolism; deubiquitination complex; Enzyme Stability; Humans; Lysine - metabolism; Nedd4 Ubiquitin Protein Ligases - metabolism; NEDD4-1; Protein Binding; Ubiquitin-Specific Proteases - metabolism; Ubiquitination; USP13; VPS34; USP13; autophagy; NEDD4-1; VPS34; deubiquitination complex; auto-ubiquitination

The class III phosphoinositide 3-kinase vacuolar protein sorting 34 (VPS34) is a core protein of autophagy initiation, yet the regulatory mechanisms responsible for its stringent control remain poorly understood. Here, we report that the E3 ubiquitin ligase NEDD4-1 promotes the autophagy flux by tar...